Retrospective evaluation of lateral ventricular volume in Parkinson's patients and control group on magnetic resonance images

Due to its flexible and expandable nature, the lateral ventricle volume has the potential to change in response to neurodegenerative diseases. Therefore, our study aims to calculate the lateral ventricle volume and its ratios to both the intracranial and cerebrum volumes and compare these measurements between Parkinson's patients and controls. By examining these ratios, we aim to better understand the relationship between lateral ventricle volume and brain structure in the context of Parkinson's disease. Magnetic resonance imaging of 54 Parkinson's patients (13 female; 41 male) and 26 healthy controls (8 female; 18 male) were included in the study. Lateral ventricle and intracranial volumes were calculated using the Cavalieri method in the ImageJ program on magnetic resonance images. Cerebrum volume was calculated using the BrainSuite program. It was observed that female patients with Parkinson's had a higher right-sided lateral ventricle volume than female controls. The right-sided lateral ventricle volume ratio to cerebrum volume and intracranial volume was also higher (p<0.05). Changes in ventricle volume are of great importance in diseases due to their relationship with anatomical structures. As seen in the results of our study, we think that the gender factor should be taken into account when evaluating the ventricle volume in neurodegenerative diseases.

Keywords:

BrainSuite, ImageJ, Horos Cerebrum Volume, Intracranial Volume,

PDF

___

1. Monje MH, Blesa J, García‐Cabezas MÁ, Obeso JA, Cavada C. Changes in thalamic dopamine innervation in a progressive Parkinson's disease model in monkeys. Movement Disorders. 2020;35(3):419-30.
2. Liu C, Jiang J, Zhou H, Zhang H, Wang M, Jiang J, et al. Brain Functional and Structural Signatures in Parkinson’s Disease. Frontiers in Aging Neuroscience. 2020;12:125.
3. Xu X, Guan X, Guo T, Zeng Q, Ye R, Wang J, et al. Brain atrophy and reorganization of structural network in Parkinson's disease with Hemiparkinsonism. Frontiers in human neuroscience. 2018;12:117.
4. Gao Y, Nie K, Huang B, Mei M, Guo M, Xie S, et al. Changes of brain structure in Parkinson’s disease patients with mild cognitive impairment analyzed via VBM technology. Neuroscience letters. 2017;658:121-32.
5. Trimarchi F, Bramanti P, Marino S, Milardi D, Di Mauro D, Ielitro G, et al. MRI 3D lateral cerebral ventricles in living humans: morphological and morphometrical age-, gender-related preliminary study. Anatomical science international. 2013;88(2):61-9.
6. Chung S-C, Tack G-R, Yi J-H, Lee B, Choi M-H, Lee B-Y, et al. Effects of gender, age, and body parameters on the ventricular volume of Korean people. Neuroscience letters. 2006;395(2):155-8.
7. Lu Z, He J, Yu Y, Li Z, Li Z, Gong J. Measurement of lateral ventricle volume of normal infant based on magnetic resonance imaging. Chinese Neurosurgical Journal. 2019;5(02):65-70.
8. Kocaman H, Acer N, Köseoğlu E, Gültekin M, Dönmez H. Evaluation of intracerebral ventricles volume of patients with Parkinson's disease using the atlas-based method: A methodological study. Journal of Chemical Neuroanatomy. 2019;98:124-30.
9. Bani-Fatemi A, Tasmim S, Graff-Guerrero A, Gerretsen P, Strauss J, Kolla N, et al. Structural and functional alterations of the suicidal brain: an updated review of neuroimaging studies. Psychiatry Research: Neuroimaging. 2018;278:77-91.
10. Woo Y, Kang W, Kang Y, Kim A, Han K-M, Tae W-S, et al. Cortical Thickness and Surface Area Abnormalities in Bipolar I and II Disorders. Psychiatry Investigation. 2021;18(9):850.
11. Jesmanas S, Gleiznienė R, Baranauskas M, Matijošaitis V, Rastenytė D. Odor Identification and Regional Gray Matter Atrophy in Patients with Alzheimer’s Disease, Parkinson’s Disease, and the Healthy Elderly: A Cross-Sectional Structural MRI Study. Brain sciences. 2021;11(10):1296.
12. Denervaud S, Korff C, Fluss J, Kalser J, Roulet-Perez E, Hagmann P, et al. Structural brain abnormalities in epilepsy with myoclonic atonic seizures. Epilepsy Research. 2021:106771.
13. Campabadal A, Abos A, Segura B, Monte‐Rubio G, Perez‐Soriano A, Giraldo DM, et al. Differentiation of multiple system atrophy subtypes by gray matter atrophy. Journal of Neuroimaging. 2021.
14. Inano S, Takao H, Hayashi N, Yoshioka N, Mori H, Kunimatsu A, et al. Effects of age and gender on neuroanatomical volumes. Journal of Magnetic Resonance Imaging. 2013;37(5):1072-6.
15. Messina D, Cerasa A, Condino F, Arabia G, Novellino F, Nicoletti G, et al. Patterns of brain atrophy in Parkinson's disease, progressive supranuclear palsy and multiple system atrophy. Parkinsonism Relat Disord. 2011;17(3):172-6.
16. Camicioli R, Sabino J, Gee M, Bouchard T, Fisher N, Hanstock C, et al. Ventricular dilatation and brain atrophy in patients with Parkinson's disease with incipient dementia. Movement disorders. 2011;26(8):1443-50.
17. Fjell AM, Walhovd KB. Structural brain changes in aging: courses, causes and cognitive consequences. Reviews in the neurosciences. 2010;21(3):187-221.
18. Acharya HJ, Bouchard TP, Emery DJ, Camicioli RM. Axial signs and magnetic resonance imaging correlates in Parkinson's disease. The Canadian journal of neurological sciences Le journal canadien des sciences neurologiques. 2007;34(1):56-61.
19. Karaca O, Buyukmert A, Tepe N, Ozcan E, Kus I. Volume estimation of brain ventricles using Cavalieri's principle and Atlas-based methods in Alzheimer disease: Consistency between methods. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2020;78:333-8.
20. Coutu JP, Goldblatt A, Rosas HD, Salat DH. White Matter Changes are Associated with Ventricular Expansion in Aging, Mild Cognitive Impairment, and Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2016;49(2):329-42.
21. Voevodskaya O, Simmons A, Nordenskjöld R, Kullberg J, Ahlström H, Lind L, et al. The effects of intracranial volume adjustment approaches on multiple regional MRI volumes in healthy aging and Alzheimer's disease. Front Aging Neurosci. 2014;6:264.
22. Förstl H, Zerfass R, Geiger-Kabisch C, Sattel H, Besthorn C, Hentschel F. Brain atrophy in normal ageing and Alzheimer's disease. Volumetric discrimination and clinical correlations. The British journal of psychiatry : the journal of mental science. 1995;167(6):739-46.
23. Abé C, Ching CRK, Liberg B, Lebedev AV, Agartz I, Akudjedu TN, et al. Longitudinal Structural Brain Changes in Bipolar Disorder: A Multicenter Neuroimaging Study of 1232 Individuals by the ENIGMA Bipolar Disorder Working Group. Biological psychiatry. 2022;91(6):582-92.
24. Okada N, Fukunaga M, Yamashita F, Koshiyama D, Yamamori H, Ohi K, et al. Abnormal asymmetries in subcortical brain volume in schizophrenia. Molecular psychiatry. 2016;21(10):1460-6.
25. Quigley SJ, Scanlon C, Kilmartin L, Emsell L, Langan C, Hallahan B, et al. Volume and shape analysis of subcortical brain structures and ventricles in euthymic bipolar I disorder. Psychiatry research. 2015;233(3):324-30.
26. Reite M, Reite E, Collins D, Teale P, Rojas DC, Sandberg E. Brain size and brain/intracranial volume ratio in major mental illness. BMC psychiatry. 2010;10(1):1-9.
27. Puri BK. Progressive structural brain changes in schizophrenia. Expert review of neurotherapeutics. 2010;10(1):33-42.
28. Radziunas A, Deltuva VP, Tamasauskas A, Gleizniene R, Pranckeviciene A, Petrikonis K, et al. Brain MRI morphometric analysis in Parkinson's disease patients with sleep disturbances. BMC Neurol. 2018;18(1):88.
29. Dalaker TO, Zivadinov R, Ramasamy DP, Beyer MK, Alves G, Bronnick KS, et al. Ventricular enlargement and mild cognitive impairment in early Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. 2011;26(2):297-301.
30. Apostolova LG, Beyer M, Green AE, Hwang KS, Morra JH, Chou YY, et al. Hippocampal, caudate, and ventricular changes in Parkinson's disease with and without dementia. Movement Disorders. 2010;25(6):687-95.
31. Lewis MM, Smith AB, Styner M, Gu H, Poole R, Zhu H, et al. Asymmetrical lateral ventricular enlargement in Parkinson’s disease. European journal of neurology. 2009;16(4):475-81.
32. Soysal H, Acer N. Volumetric measurements of the subcortical structures of healthy adult brains in the Turkish population. 2022;81(2):294-306.
33. Akdogan I, Kiroglu Y, Onur S, Karabulut N. The volume fraction of brain ventricles to total brain volume: a computed tomography stereological study. Folia morphologica. 2010;69(4):193-200.
34. Ertekin T, Acer N, Köseoğlu E, Zararsız G, Sönmez A, Gümüş K, et al. Total intracranial and lateral ventricle volumes measurement in Alzheimer’s disease: A methodological study. Journal of Clinical Neuroscience. 2016;34:133-9.