Farhat CHAUDHARİ, Ahmad ALİ, Prairna BALYAN

Mechanisms and therapeutic opportunities in erectile dysfunction for advanced glycation end products (AGEs)

Diabetes mellitus (DM) is one of the world's most common diseases. Its impact on the male reproductive system is one of its key impacts. Erectile dysfunction and decreased libido affect up to 90% of diabetic men, which can result in male infertility. Several researchers have investigated the negative impacts of reactive oxygen species and the subsequent development of oxidative stress that occurs due to DM. Non-enzymatic glycosylation products (AGEs) have been found in diabetic men's reproductive tracts. AGEs work by generating reactive oxygen species (ROS) or attaching to receptors on their own. The binding of AGE to the receptor (RAGE) has been demonstrated to play a role in physiological processes such as lung homeostasis, bone metabolism, neural systems, and the immune system. The human body has several defenses against AGE accumulation, which are reduced in diabetic individuals. The situation can be improved by using some preventive measures, either by using oral drugs or natural therapeutic agents. Also, herbal medicine is gaining popularity in the market to treat various ailments. Because of the long cultural history of use and the present resurgent interest, using herbal treatments to manage male sexual dysfunction is beneficial.

Keywords:

Diabetes, Erectile Dysfunction (ED) Male infertility, Receptor for Advanced glycation end products (RAGE), Reactive Oxygen Species (ROS),

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1. Asafu-Adjei DA, Gittens PR. Diabetes and Male Infertility. In: Male Infertility. 2020.
1. Asafu-Adjei DA, Gittens PR. Diabetes and Male Infertility. In: Male Infertility. 2020.
2. Turchi P. Prevalence, definition, and classification of infertility. In: Clinical Management of Male Infertility. 2015.
2. Turchi P. Prevalence, definition, and classification of infertility. In: Clinical Management of Male Infertility. 2015.
3. Fainberg J, Kashanian JA. Recent advances in understanding and managing male infertility. F1000Research. 2019;8.
3. Fainberg J, Kashanian JA. Recent advances in understanding and managing male infertility. F1000Research. 2019;8.
4. Ding GL, Liu Y, Liu ME, Pan JX, Guo MX, Sheng JZ, et al. The effects of diabetes on male fertility and epigenetic regulation during spermatogenesis. Vol. 17, Asian Journal of Andrology. 2015.
4. Ding GL, Liu Y, Liu ME, Pan JX, Guo MX, Sheng JZ, et al. The effects of diabetes on male fertility and epigenetic regulation during spermatogenesis. Vol. 17, Asian Journal of Andrology. 2015.
5. Omolaoye TS, du Plessis SS. Male infertility: A proximate look at the advanced glycation end products. Vol. 93, Reproductive Toxicology. 2020.
5. Omolaoye TS, du Plessis SS. Male infertility: A proximate look at the advanced glycation end products. Vol. 93, Reproductive Toxicology. 2020.
6. Shamloul R, Ghanem H. Erectile dysfunction. Vol. 381, The Lancet. 2013.
6. Shamloul R, Ghanem H. Erectile dysfunction. Vol. 381, The Lancet. 2013.
7. Cellek S, Cameron NE, Cotter MA, Muneer A. Pathophysiology of diabetic erectile dysfunction: Potential contribution of vasa nervorum and advanced glycation endproducts. Vol. 25, International Journal of Impotence Research. 2013.
7. Cellek S, Cameron NE, Cotter MA, Muneer A. Pathophysiology of diabetic erectile dysfunction: Potential contribution of vasa nervorum and advanced glycation endproducts. Vol. 25, International Journal of Impotence Research. 2013.
8. Selvin E, Burnett AL, Platz EA. Prevalence and Risk Factors for Erectile Dysfunction in the US. American Journal of Medicine. 2007;120(2).
8. Selvin E, Burnett AL, Platz EA. Prevalence and Risk Factors for Erectile Dysfunction in the US. American Journal of Medicine. 2007;120(2).
9. El-Sakka AI, Lue TF. Physiology of penile erection. Vol. 4 Suppl 1, The Scientific World Journal. 2004.
9. El-Sakka AI, Lue TF. Physiology of penile erection. Vol. 4 Suppl 1, The Scientific World Journal. 2004.
10. Tejada ISD, Angulo N, Clark S, González-Cadavid N, Heaton J, Pickard R, Simonsen U. Pathophysiology of erectile dysfunction. Vol. 2, Journal of Sexual Medicine.2005.
10. Tejada ISD, Angulo N, Clark S, González-Cadavid N, Heaton J, Pickard R, Simonsen U. Pathophysiology of erectile dysfunction. Vol. 2, Journal of Sexual Medicine.2005.
11. Fournet M, Bonté F, Desmoulière A. Glycation damage: A possible hub for major pathophysiological disorders and aging. Vol. 9, Aging and Disease. 2018.
11. Fournet M, Bonté F, Desmoulière A. Glycation damage: A possible hub for major pathophysiological disorders and aging. Vol. 9, Aging and Disease. 2018.
12. Mallidis C, Agbaje I, Rogers D, Glenn J, McCullough S, Atkinson AB, et al. Distribution of the receptor for advanced glycation end products in the human male reproductive tract: Prevalence in men with diabetes mellitus. Human Reproduction. 2007;22(8).
12. Mallidis C, Agbaje I, Rogers D, Glenn J, McCullough S, Atkinson AB, et al. Distribution of the receptor for advanced glycation end products in the human male reproductive tract: Prevalence in men with diabetes mellitus. Human Reproduction. 2007;22(8).
13. Neves D. Advanced glycation end-products: A common pathway in diabetes and age-related erectile dysfunction. Vol. 47, Free Radical Research. 2013.
13. Neves D. Advanced glycation end-products: A common pathway in diabetes and age-related erectile dysfunction. Vol. 47, Free Radical Research. 2013.
14. Tuncayengin A, Biri H, Onaran M, Şen I, Tuncayengin Ö, Polat F, et al. Cavernosal tissue nitrite, nitrate, malondialdehyde and glutathione levels in diabetic and non-diabetic erectile dysfunction. International Journal of Andrology. 2003;26(4).
14. Tuncayengin A, Biri H, Onaran M, Şen I, Tuncayengin Ö, Polat F, et al. Cavernosal tissue nitrite, nitrate, malondialdehyde and glutathione levels in diabetic and non-diabetic erectile dysfunction. International Journal of Andrology. 2003;26(4).
15. Cartledge JJ, Eardley I, Morrison JFB. Advanced glycation end-products are responsible for the impairment of corpus cavernosal smooth muscle relaxation seen in diabetes. BJU International. 2001;87(4).
15. Cartledge JJ, Eardley I, Morrison JFB. Advanced glycation end-products are responsible for the impairment of corpus cavernosal smooth muscle relaxation seen in diabetes. BJU International. 2001;87(4).
16. Chen Y, Dai Y, Wang R. Treatment strategies for diabetic patients suffering from erectile dysfunction. Vol. 9, Expert Opinion on Pharmacotherapy. 2008.
16. Chen Y, Dai Y, Wang R. Treatment strategies for diabetic patients suffering from erectile dysfunction. Vol. 9, Expert Opinion on Pharmacotherapy. 2008.
17. Lin F, Gou X. Panax notoginseng saponins improve the erectile dysfunction in diabetic rats by protecting the endothelial function of the penile corpus cavernosum. International Journal of Impotence Research. 2013;25(6).
17. Lin F, Gou X. Panax notoginseng saponins improve the erectile dysfunction in diabetic rats by protecting the endothelial function of the penile corpus cavernosum. International Journal of Impotence Research. 2013;25(6).
18. Corazza O, Martinotti G, Santacroce R, Chillemi E, Di Giannantonio M, Schifano F, et al. Sexual enhancement products for sale online: Raising awareness of the psychoactive effects of yohimbine, maca, horny goat weed, and ginkgo biloba. Vol. 2014, BioMed Research International. 2014.
18. Corazza O, Martinotti G, Santacroce R, Chillemi E, Di Giannantonio M, Schifano F, et al. Sexual enhancement products for sale online: Raising awareness of the psychoactive effects of yohimbine, maca, horny goat weed, and ginkgo biloba. Vol. 2014, BioMed Research International. 2014.
19. Jha J, Kumari S, Jobby R, Desai N, Ali A. Dietary phytonutrients in the prevention of diabetes-related complications. Vol. 16, Current Diatebes Reviews. 2020 657-673.
19. Jha J, Kumari S, Jobby R, Desai N, Ali A. Dietary phytonutrients in the prevention of diabetes-related complications. Vol. 16, Current Diatebes Reviews. 2020 657-673.
20. Forouhi NG, Wareham NJ. Epidemiology of diabetes. Vol. 38, Medicine. 2010.
20. Forouhi NG, Wareham NJ. Epidemiology of diabetes. Vol. 38, Medicine. 2010.
21. Fernández-Miró M, Chillarón JJ, Pedro-Botet J. Testosterone deficiency, metabolic syndrome and diabetes mellitus. Medicina Clínica (English Edition). 2016;146(2).
21. Fernández-Miró M, Chillarón JJ, Pedro-Botet J. Testosterone deficiency, metabolic syndrome and diabetes mellitus. Medicina Clínica (English Edition). 2016;146(2).
22. Kasturi SS, Tannir J, Brannigan RE. The metabolic syndrome and male infertility. Vol. 29, Journal of Andrology. 2008.
22. Kasturi SS, Tannir J, Brannigan RE. The metabolic syndrome and male infertility. Vol. 29, Journal of Andrology. 2008.
23. Amaral S, Moreno AJ, Santos MS, Seiça R, Ramalho-Santos J. Effects of hyperglycemia on sperm and testicular cells of Goto-Kakizaki and streptozotocin-treated rat models for diabetes. Theriogenology. 2006;66(9).
23. Amaral S, Moreno AJ, Santos MS, Seiça R, Ramalho-Santos J. Effects of hyperglycemia on sperm and testicular cells of Goto-Kakizaki and streptozotocin-treated rat models for diabetes. Theriogenology. 2006;66(9).
24. Ohlander SJ, Lindgren MC, Lipshultz LI. Testosterone and Male Infertility. Vol. 43, Urologic Clinics of North America. 2016.
24. Ohlander SJ, Lindgren MC, Lipshultz LI. Testosterone and Male Infertility. Vol. 43, Urologic Clinics of North America. 2016.
25. Shen JK, Cheriyan SK, Ko EY. Ejaculatory Dysfunction: Retrograde Ejaculation. In: The Diagnosis and Treatment of Male Infertility. 2017.
25. Shen JK, Cheriyan SK, Ko EY. Ejaculatory Dysfunction: Retrograde Ejaculation. In: The Diagnosis and Treatment of Male Infertility. 2017.
26. Beretta G. Sexual problems and infertility. In: Clinical Management of Male Infertility. 2015.
26. Beretta G. Sexual problems and infertility. In: Clinical Management of Male Infertility. 2015.
27. Sam P, LaGrange CA. Anatomy, Abdomen and Pelvis, Penis. StatPearls. 2018.
27. Sam P, LaGrange CA. Anatomy, Abdomen and Pelvis, Penis. StatPearls. 2018.
28. Glina S, Cohen DJ, Vieira M. Diagnosis of erectile dysfunction. Vol. 27, Current Opinion in Psychiatry. 2014.
28. Glina S, Cohen DJ, Vieira M. Diagnosis of erectile dysfunction. Vol. 27, Current Opinion in Psychiatry. 2014.
29. Sooriyamoorthy T, Leslie SW. Erectile Dysfunction, In: Stat Pearls [Internet], Treasure Island (FL): Stat Pearls Publishing. 2021.
29. Sooriyamoorthy T, Leslie SW. Erectile Dysfunction, In: Stat Pearls [Internet], Treasure Island (FL): Stat Pearls Publishing. 2021.
30. Carson CC, Dean JD. Management of erectile dysfunction in clinical practice. Management of Erectile Dysfunction in Clinical Practice. 2007.
30. Carson CC, Dean JD. Management of erectile dysfunction in clinical practice. Management of Erectile Dysfunction in Clinical Practice. 2007.
31. Ledda A. Diabetes, Hypertension and Erectile Dysfunction. Current Medical Research and Opinion. 2000;16(sup1).
31. Ledda A. Diabetes, Hypertension and Erectile Dysfunction. Current Medical Research and Opinion. 2000;16(sup1).
32. McVary KT. Erectile dysfunction, Vol. 357, New England Journal of Medicine. 2007.
32. McVary KT. Erectile dysfunction, Vol. 357, New England Journal of Medicine. 2007.
33. Nunes KP, Webb RC. , Mechanisms in erectile function and dysfunction: an overview. In: Erectile dysfunction- Disease associated mechanisms and novel insights into therapy. 2012.
33. Nunes KP, Webb RC. , Mechanisms in erectile function and dysfunction: an overview. In: Erectile dysfunction- Disease associated mechanisms and novel insights into therapy. 2012.
34. Toda N, Ayajiki K, Okamura T. Nitric oxide and penile erectile function. Vol. 106, Pharmacology and Therapeutics. 2005.
34. Toda N, Ayajiki K, Okamura T. Nitric oxide and penile erectile function. Vol. 106, Pharmacology and Therapeutics. 2005.
35. Burnett AL. The role of nitric oxide in erectile dysfunction: implications for medical therapy. Vol. 8, Journal of clinical hypertension (Greenwich, Conn.). 2006.
35. Burnett AL. The role of nitric oxide in erectile dysfunction: implications for medical therapy. Vol. 8, Journal of clinical hypertension (Greenwich, Conn.). 2006.
36. Andersson KE. Mechanisms of penile erection and basis for pharmacological treatment of erectile dysfunction. Pharmacological Reviews. 2011;63(4).
36. Andersson KE. Mechanisms of penile erection and basis for pharmacological treatment of erectile dysfunction. Pharmacological Reviews. 2011;63(4).
37. Hampl V, Huang JM, Weir EK, Archer SL. Activation of the cGMP-dependent protein kinase mimics the stimulatory effect of nitric oxide and cGMP on calcium-gated potassium channels. In: Physiological Research. 1995.
37. Hampl V, Huang JM, Weir EK, Archer SL. Activation of the cGMP-dependent protein kinase mimics the stimulatory effect of nitric oxide and cGMP on calcium-gated potassium channels. In: Physiological Research. 1995.
38. Kaya C, Uslu Z, Karaman I. Is endothelial function impaired in erectile dysfunction patients? International Journal of Impotence Research. 2006;18(1).
38. Kaya C, Uslu Z, Karaman I. Is endothelial function impaired in erectile dysfunction patients? International Journal of Impotence Research. 2006;18(1).
39. Fabbri A, Aversa A, Isidori A. Erectile dysfunction: An overview. Vol. 3, Human Reproduction Update. 1997.
39. Fabbri A, Aversa A, Isidori A. Erectile dysfunction: An overview. Vol. 3, Human Reproduction Update. 1997.
40. Kim C-S, Park S, Kim J. The role of glycation in the pathogenesis of aging and its prevention through herbal products and physical exercise. Journal of Exercise Nutrition & Biochemistry. 2017;21(3).
40. Kim C-S, Park S, Kim J. The role of glycation in the pathogenesis of aging and its prevention through herbal products and physical exercise. Journal of Exercise Nutrition & Biochemistry. 2017;21(3).
41. Schleicher ED, Bierhaus A, Häring HU, Nawroth PP, Lehmann R. Chemistry and pathobiology of advanced glycation end products. Contributions to Nephrology. 2001;131.
41. Schleicher ED, Bierhaus A, Häring HU, Nawroth PP, Lehmann R. Chemistry and pathobiology of advanced glycation end products. Contributions to Nephrology. 2001;131.
42. Singh R, Barden A, Mori T, Beilin L. Advanced glycation end-products: A review. Vol. 44, Diabetologia. 2001.
42. Singh R, Barden A, Mori T, Beilin L. Advanced glycation end-products: A review. Vol. 44, Diabetologia. 2001.
43. Perrone A, Giovino A, Benny J, Martinelli F. Advanced Glycation End Products (AGEs): Biochemistry, Signaling, Analytical Methods, and Epigenetic Effects. Vol. 2020, Oxidative Medicine and Cellular Longevity. 2020.
43. Perrone A, Giovino A, Benny J, Martinelli F. Advanced Glycation End Products (AGEs): Biochemistry, Signaling, Analytical Methods, and Epigenetic Effects. Vol. 2020, Oxidative Medicine and Cellular Longevity. 2020.
44. Goldin A, Beckman JA, Schmidt AM, Creager MA. Advanced glycation end products: Sparking the development of diabetic vascular injury. Vol. 114, Circulation. 2006.
44. Goldin A, Beckman JA, Schmidt AM, Creager MA. Advanced glycation end products: Sparking the development of diabetic vascular injury. Vol. 114, Circulation. 2006.
45. Jud P, Sourij H. Therapeutic options to reduce advanced glycation end products in patients with diabetes mellitus: A review. Vol. 148, Diabetes Research and Clinical Practice. 2019.
45. Jud P, Sourij H. Therapeutic options to reduce advanced glycation end products in patients with diabetes mellitus: A review. Vol. 148, Diabetes Research and Clinical Practice. 2019.
46. Charalampidou S, Simitsopoulou M, Skoura L, Tziomalos K, Koulourida V, Goulis DG. Soluble receptor for advanced glycation end products in male infertility. Hippokratia. 2017;21(1).
46. Charalampidou S, Simitsopoulou M, Skoura L, Tziomalos K, Koulourida V, Goulis DG. Soluble receptor for advanced glycation end products in male infertility. Hippokratia. 2017;21(1).
47. Maresch CC, Stute DC, Fleming T, Lin J, Hammes HP, Linn T. Hyperglycemia induces spermatogenic disruption via major pathways of diabetes pathogenesis. Scientific Reports. 2019;9(1).
47. Maresch CC, Stute DC, Fleming T, Lin J, Hammes HP, Linn T. Hyperglycemia induces spermatogenic disruption via major pathways of diabetes pathogenesis. Scientific Reports. 2019;9(1).
48. Zhao YT, Qi YW, Hu CY, Chen SH, Liu Y. Advanced glycation end products inhibit testosterone secretion by rat Leydig cells by inducing oxidative stress and endoplasmic reticulum stress. International Journal of Molecular Medicine. 2016;38(2).
48. Zhao YT, Qi YW, Hu CY, Chen SH, Liu Y. Advanced glycation end products inhibit testosterone secretion by rat Leydig cells by inducing oxidative stress and endoplasmic reticulum stress. International Journal of Molecular Medicine. 2016;38(2).
49. Akbarian F, Rahmani M, Tavalaee M, Abedpoor N, Taki M, Ghaedi K, et al. Effect of different high-fat and advanced glycation end-products diets in obesity and diabetes-prone c57bl/6 mice on sperm function. International Journal of Fertility and Sterility. 2021;15(3).
49. Akbarian F, Rahmani M, Tavalaee M, Abedpoor N, Taki M, Ghaedi K, et al. Effect of different high-fat and advanced glycation end-products diets in obesity and diabetes-prone c57bl/6 mice on sperm function. International Journal of Fertility and Sterility. 2021;15(3).
50. Boydens C, Pauwels B, Vanden Daele L, Van de Voorde J. Protective effect of resveratrol and quercetin on in vitro-induced diabetic mouse corpus cavernosum. Cardiovascular Diabetology. 2016;15(1).
50. Boydens C, Pauwels B, Vanden Daele L, Van de Voorde J. Protective effect of resveratrol and quercetin on in vitro-induced diabetic mouse corpus cavernosum. Cardiovascular Diabetology. 2016;15(1).
51. Stöckl JB, Schmid N, Flenkenthaler F, Drummer C, Behr R, Mayerhofer A, et al. Age‐related alterations in the testicular proteome of a non‐human primate. Cells. 2021;10(6).
51. Stöckl JB, Schmid N, Flenkenthaler F, Drummer C, Behr R, Mayerhofer A, et al. Age‐related alterations in the testicular proteome of a non‐human primate. Cells. 2021;10(6).
52. Lewis RW. Epidemiology of erectile dysfunction. Vol. 28, Urologic Clinics of North America. 2001.
52. Lewis RW. Epidemiology of erectile dysfunction. Vol. 28, Urologic Clinics of North America. 2001.
53. Thorve VS, Kshirsagar AD, Vyawahare NS, Joshi VS, Ingale KG, Mohite RJ. Diabetes-induced erectile dysfunction: Epidemiology, pathophysiology and management. Vol. 25, Journal of Diabetes and its Complications. 2011.
53. Thorve VS, Kshirsagar AD, Vyawahare NS, Joshi VS, Ingale KG, Mohite RJ. Diabetes-induced erectile dysfunction: Epidemiology, pathophysiology and management. Vol. 25, Journal of Diabetes and its Complications. 2011.
54. Taneda S, Monnier VM. ELISA of pentosidine, an advanced glycation end product, in biological specimens. Clinical Chemistry. 1994;40(9).
54. Taneda S, Monnier VM. ELISA of pentosidine, an advanced glycation end product, in biological specimens. Clinical Chemistry. 1994;40(9).
55. Kamenov ZA. A comprehensive review of erectile dysfunction in men with diabetes. Vol. 123, Experimental and Clinical Endocrinology and Diabetes. 2015.
55. Kamenov ZA. A comprehensive review of erectile dysfunction in men with diabetes. Vol. 123, Experimental and Clinical Endocrinology and Diabetes. 2015.
56. Seftel AD, Vaziri ND, Zhemnin NI, Razmjouei K, Fogarty J, Hampel N, et al. Advanced glycation end products in human penis: Elevation in diabetic tissue, site of deposition, and possible effect through iNos or eNos. Urology. 1997;50(6).
56. Seftel AD, Vaziri ND, Zhemnin NI, Razmjouei K, Fogarty J, Hampel N, et al. Advanced glycation end products in human penis: Elevation in diabetic tissue, site of deposition, and possible effect through iNos or eNos. Urology. 1997;50(6).
57. Anwar Z, Sinha V, Mitra S, Mishra AK, Ansari MH, Bharti A, Nigam AK. Erectile dysfunction: An underestimated presentation in patients with diabetes mellitus. Indian Journal of Psychological Medicine. 2017
57. Anwar Z, Sinha V, Mitra S, Mishra AK, Ansari MH, Bharti A, Nigam AK. Erectile dysfunction: An underestimated presentation in patients with diabetes mellitus. Indian Journal of Psychological Medicine. 2017
58. Moore CR, Wang R. Pathophysiology and treatment of diabetic erectile dysfunction. Vol. 8, Asian Journal of Andrology. 2006.
58. Moore CR, Wang R. Pathophysiology and treatment of diabetic erectile dysfunction. Vol. 8, Asian Journal of Andrology. 2006.
59. Poojari P, Padgaonkar A, Paramanya A, Ali A. Compendium of polycystic ovarian syndrome and its relevance in glycation and diabetes. Journal of Experimental and Clinical Medicine. Vol. 39. 2022.
59. Poojari P, Padgaonkar A, Paramanya A, Ali A. Compendium of polycystic ovarian syndrome and its relevance in glycation and diabetes. Journal of Experimental and Clinical Medicine. Vol. 39. 2022.
60. Takahashi K, Takeya M, Sakashita N. Multifunctional roles of macrophages in the development and progression of atherosclerosis in humans and experimental animals. Vol. 35, Medical Electron Microscopy. 2002.
60. Takahashi K, Takeya M, Sakashita N. Multifunctional roles of macrophages in the development and progression of atherosclerosis in humans and experimental animals. Vol. 35, Medical Electron Microscopy. 2002.
61. Wada R, Yagihashi S. Role of advanced glycation end products and their receptors in development of diabetic neuropathy. In: Annals of the New York Academy of Sciences. 2005.
61. Wada R, Yagihashi S. Role of advanced glycation end products and their receptors in development of diabetic neuropathy. In: Annals of the New York Academy of Sciences. 2005.
62. Thornalley PJ. Cell activation by glycated proteins. AGE receptors, receptor recognition factors and functional classification of AGEs. Vol. 44, Cellular and molecular biology (Noisy-le-Grand, France). 1998.
62. Thornalley PJ. Cell activation by glycated proteins. AGE receptors, receptor recognition factors and functional classification of AGEs. Vol. 44, Cellular and molecular biology (Noisy-le-Grand, France). 1998.
63. Lu C, He JC, Cai W, Liu HI, Zhu L, Vlassara H. Advanced glycation product (AGE) receptor 1 is a negative regulator of the inflammatory response to AGE in mesangial cells. Proceedings of the National Academy of Sciences of the United States of America. 2004;101(32).
63. Lu C, He JC, Cai W, Liu HI, Zhu L, Vlassara H. Advanced glycation product (AGE) receptor 1 is a negative regulator of the inflammatory response to AGE in mesangial cells. Proceedings of the National Academy of Sciences of the United States of America. 2004;101(32).
64. Cai W, Torreggiani M, Zhu L, Chen X, He JC, Striker GE, et al. AGER1 regulates endothelial cell NADPH oxidase-dependent oxidant stress via PKC-δ: Implications for vascular disease. American Journal of Physiology - Cell Physiology. 2010;298(3).
64. Cai W, Torreggiani M, Zhu L, Chen X, He JC, Striker GE, et al. AGER1 regulates endothelial cell NADPH oxidase-dependent oxidant stress via PKC-δ: Implications for vascular disease. American Journal of Physiology - Cell Physiology. 2010;298(3).
65. Bierhaus A, Hofmann MA, Ziegler R, Nawroth PP. AGEs and their interaction with AGE-receptors in vascular disease and diabetes mellitus. I. The AGE concept. Vol. 37, Cardiovascular Research. 1998.
65. Bierhaus A, Hofmann MA, Ziegler R, Nawroth PP. AGEs and their interaction with AGE-receptors in vascular disease and diabetes mellitus. I. The AGE concept. Vol. 37, Cardiovascular Research. 1998.
66. Hatzimouratidis K, Hatzichristou DG. A comparative review of the options for treatment of erectile dysfunction: Which treatment for which patient? Vol. 65, Drugs. 2005.
66. Hatzimouratidis K, Hatzichristou DG. A comparative review of the options for treatment of erectile dysfunction: Which treatment for which patient? Vol. 65, Drugs. 2005.
67. Ciocanel O, Power K, Eriksen A. Interventions to Treat Erectile Dysfunction and Premature Ejaculation: An Overview of Systematic Reviews. Vol. 7, Sexual Medicine. 2019.
67. Ciocanel O, Power K, Eriksen A. Interventions to Treat Erectile Dysfunction and Premature Ejaculation: An Overview of Systematic Reviews. Vol. 7, Sexual Medicine. 2019.
68. Yang R, Wang J, Chen Y, Sun Z, Wang R, Dai Y. Effect of caffeine on erectile function via up-regulating cavernous cyclic guanosine monophosphate in diabetic rats. Journal of Andrology. 2008;29(5).
68. Yang R, Wang J, Chen Y, Sun Z, Wang R, Dai Y. Effect of caffeine on erectile function via up-regulating cavernous cyclic guanosine monophosphate in diabetic rats. Journal of Andrology. 2008;29(5).
69. Das A, Durrant D, Salloum FN, Xi L, Kukreja RC. PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer. Vol. 147, Pharmacology and Therapeutics. 2015.
69. Das A, Durrant D, Salloum FN, Xi L, Kukreja RC. PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer. Vol. 147, Pharmacology and Therapeutics. 2015.
70. Keating GM, Scott LJ. Vardenafil: A Review of its Use in Erectile Dysfunction. Vol. 63, Drugs. 2003.
70. Keating GM, Scott LJ. Vardenafil: A Review of its Use in Erectile Dysfunction. Vol. 63, Drugs. 2003.
71. Ishibashi Y, Matsui T, Takeuchi M, Yamagishi SI. Vardenafil, an inhibitor of phosphodiesterase-5, blocks advanced glycation end product (AGE)-induced up-regulation of monocyte chemoattractant protein-1 mRNA levels in endothelial cells by suppressing AGE receptor (RAGE) expression via elevation of cGMP. Clinical and Experimental Medicine. 2011;11(2).
71. Ishibashi Y, Matsui T, Takeuchi M, Yamagishi SI. Vardenafil, an inhibitor of phosphodiesterase-5, blocks advanced glycation end product (AGE)-induced up-regulation of monocyte chemoattractant protein-1 mRNA levels in endothelial cells by suppressing AGE receptor (RAGE) expression via elevation of cGMP. Clinical and Experimental Medicine. 2011;11(2).
72. Boulton AJM, Selam JL, Sweeney M, Ziegler D. Sildenafil citrate for the treatment of erectile dysfunction in men with Type II diabetes mellitus. Diabetologia. 2001;44(10).
72. Boulton AJM, Selam JL, Sweeney M, Ziegler D. Sildenafil citrate for the treatment of erectile dysfunction in men with Type II diabetes mellitus. Diabetologia. 2001;44(10).
73. Gurbuz N, Sagdic G, Sanli A, Ciftcioglu A, Bassorgun I, Baykal A, et al. Therapeutic effect of combination of alagebrium (ALT-711) and sildenafil on erectile function in diabetic rats. International Journal of Impotence Research. 2012;24(3).
73. Gurbuz N, Sagdic G, Sanli A, Ciftcioglu A, Bassorgun I, Baykal A, et al. Therapeutic effect of combination of alagebrium (ALT-711) and sildenafil on erectile function in diabetic rats. International Journal of Impotence Research. 2012;24(3).
74. Huang SA, Lie JD. Phosphodiesterase-5 (PDE5) inhibitors in the management of erectile dysfunction. Vol. 38, P and T. 2013.
74. Huang SA, Lie JD. Phosphodiesterase-5 (PDE5) inhibitors in the management of erectile dysfunction. Vol. 38, P and T. 2013.
75. Nilsson BO. Biological effects of aminoguanidine: An update. Vol. 48, Inflammation Research. 1999.
75. Nilsson BO. Biological effects of aminoguanidine: An update. Vol. 48, Inflammation Research. 1999.
76. Usta MF, Bivalacqua TJ, Koksal IT, Toptas B, Surmen S, Hellstrom WJG. The protective effect of aminoguanidine on erectile function in diabetic rats is not related to the timing of treatment. BJU International. 2004;94(3).
76. Usta MF, Bivalacqua TJ, Koksal IT, Toptas B, Surmen S, Hellstrom WJG. The protective effect of aminoguanidine on erectile function in diabetic rats is not related to the timing of treatment. BJU International. 2004;94(3).
77. Seftel AD. Phosphodiesterase Type 5 Inhibitor Differentiation Based on Selectivity, Pharmacokinetic, and Efficacy Profiles. In: Clinical Cardiology. 2004.
77. Seftel AD. Phosphodiesterase Type 5 Inhibitor Differentiation Based on Selectivity, Pharmacokinetic, and Efficacy Profiles. In: Clinical Cardiology. 2004.
78. Krzastek SC, Bopp J, Smith RP, Kovac JR. Recent advances in the understanding and management of erectile dysfunction [version 1; referees: 2 approved]. Vol. 8, F1000Research. 2019.
78. Krzastek SC, Bopp J, Smith RP, Kovac JR. Recent advances in the understanding and management of erectile dysfunction [version 1; referees: 2 approved]. Vol. 8, F1000Research. 2019.
79. Belew D, Klaassen Z, Lewis RW. Intracavernosal Injection for the Diagnosis, Evaluation, and Treatment of Erectile Dysfunction: A Review. Vol. 3, Sexual Medicine Reviews. 2015.
79. Belew D, Klaassen Z, Lewis RW. Intracavernosal Injection for the Diagnosis, Evaluation, and Treatment of Erectile Dysfunction: A Review. Vol. 3, Sexual Medicine Reviews. 2015.
80. Duncan C, Omran GJ, Teh J, Davis NF, Bolton DM, Lawrentschuk N. Erectile dysfunction: a global review of intracavernosal injectables. World Journal of Urology. 2019.
80. Duncan C, Omran GJ, Teh J, Davis NF, Bolton DM, Lawrentschuk N. Erectile dysfunction: a global review of intracavernosal injectables. World Journal of Urology. 2019.
81. Pastuszak AW. Current Diagnosis and Management of Erectile Dysfunction. Current Sexual Health Reports. 2014;6(3).
81. Pastuszak AW. Current Diagnosis and Management of Erectile Dysfunction. Current Sexual Health Reports. 2014;6(3).
82. Chung. A Review of Current and Emerging Therapeutic Options for Erectile Dysfunction. Medical Sciences. 2019;7(9).
82. Chung. A Review of Current and Emerging Therapeutic Options for Erectile Dysfunction. Medical Sciences. 2019;7(9).
83. Hellstrom WJG, Montague DK, Moncada I, Carson C, Minhas S, Faria G, et al. Implants, mechanical devices, and vascular surgery for erectile dysfunction. Journal of Sexual Medicine. 2010;7(1 PART 2).
83. Hellstrom WJG, Montague DK, Moncada I, Carson C, Minhas S, Faria G, et al. Implants, mechanical devices, and vascular surgery for erectile dysfunction. Journal of Sexual Medicine. 2010;7(1 PART 2).
84. Nadig PW. Vacuum constriction devices in patients with neurogenic impotence. Sexuality and Disability. 1994;12(1).
84. Nadig PW. Vacuum constriction devices in patients with neurogenic impotence. Sexuality and Disability. 1994;12(1).
85. Brison D, Seftel A, Sadeghi-Nejad H. The Resurgence of the Vacuum Erection Device (VED) for Treatment of Erectile Dysfunction. Journal of Sexual Medicine. 2013;10(4).
85. Brison D, Seftel A, Sadeghi-Nejad H. The Resurgence of the Vacuum Erection Device (VED) for Treatment of Erectile Dysfunction. Journal of Sexual Medicine. 2013;10(4).
86. Dutta TC, Eid JF. Vacuum constriction devices for erectile dysfunction: A long-term, prospective study of patients with mild, moderate, and severe dysfunction. Urology. 1999;54(5).
86. Dutta TC, Eid JF. Vacuum constriction devices for erectile dysfunction: A long-term, prospective study of patients with mild, moderate, and severe dysfunction. Urology. 1999;54(5).
87. Mulcahy JJ. The Development of Modern Penile Implants. Vol. 4, Sexual Medicine Reviews. 2016.
87. Mulcahy JJ. The Development of Modern Penile Implants. Vol. 4, Sexual Medicine Reviews. 2016.
88. Mulcahy JJ, Austoni E, Barada JH, Choi HK, Hellstrom WJG, Krishnamurti S, et al. The penile implant for erectile dysfunction. Journal of Sexual Medicine. 2004;1(1).
88. Mulcahy JJ, Austoni E, Barada JH, Choi HK, Hellstrom WJG, Krishnamurti S, et al. The penile implant for erectile dysfunction. Journal of Sexual Medicine. 2004;1(1).
89. Carson CC. Diagnosis, treatment and prevention of penile prosthesis infection. In: International Journal of Impotence Research. 2003.
89. Carson CC. Diagnosis, treatment and prevention of penile prosthesis infection. In: International Journal of Impotence Research. 2003.
90. Ali A. Herbs that heal: The philanthropic behaviour of nature. Annals of Phytomedicine: An International Journal. 2020;9(1).
90. Ali A. Herbs that heal: The philanthropic behaviour of nature. Annals of Phytomedicine: An International Journal. 2020;9(1).
91. Calixto JB. The role of natural products in modern drug discovery. Anais da Academia Brasileira de Ciencias. 2019;91.
91. Calixto JB. The role of natural products in modern drug discovery. Anais da Academia Brasileira de Ciencias. 2019;91.
92. Park NC, Kim SW, Hwang SY, Park HJ. Efficacy and safety of an herbal formula (KBMSI-2) in the treatment of erectile dysfunction: A preliminary clinical study. Investigative and Clinical Urology. 2019;60(4).
92. Park NC, Kim SW, Hwang SY, Park HJ. Efficacy and safety of an herbal formula (KBMSI-2) in the treatment of erectile dysfunction: A preliminary clinical study. Investigative and Clinical Urology. 2019;60(4).
93. Masuku NP, Unuofin JO, Lebelo SL. Promising role of medicinal plants in the regulation and management of male erectile dysfunction. Vol. 130, Biomedicine and Pharmacotherapy. 2020.
93. Masuku NP, Unuofin JO, Lebelo SL. Promising role of medicinal plants in the regulation and management of male erectile dysfunction. Vol. 130, Biomedicine and Pharmacotherapy. 2020.
94. Hu TY, Liu CL, Chyau CC, Hu ML. Trapping of methylglyoxal by curcumin in cell-free systems and in human umbilical vein endothelial cells. Journal of Agricultural and Food Chemistry. 2012;60(33).
94. Hu TY, Liu CL, Chyau CC, Hu ML. Trapping of methylglyoxal by curcumin in cell-free systems and in human umbilical vein endothelial cells. Journal of Agricultural and Food Chemistry. 2012;60(33).
95. Abdel Aziz MT, Motawi T, Rezq A, Mostafa T, Fouad HH, Ahmed HH, et al. Effects of a Water-Soluble Curcumin Protein Conjugate vs. Pure Curcumin in a Diabetic Model of Erectile Dysfunction. Journal of Sexual Medicine. 2012;9(7).
95. Abdel Aziz MT, Motawi T, Rezq A, Mostafa T, Fouad HH, Ahmed HH, et al. Effects of a Water-Soluble Curcumin Protein Conjugate vs. Pure Curcumin in a Diabetic Model of Erectile Dysfunction. Journal of Sexual Medicine. 2012;9(7).
96. Ho CCK, Tan HM. Rise of herbal and traditional medicine in erectile dysfunction management. Current Urology Reports. 2011;12(6).
96. Ho CCK, Tan HM. Rise of herbal and traditional medicine in erectile dysfunction management. Current Urology Reports. 2011;12(6).
97. Shindel AW, Xin ZC, Lin G, Fandel TM, Huang YC, Banie L, et al. Erectogenic and neurotrophic effects of icariin, a purified extract of horny goat weed (Epimedium spp.) in vitro and in vivo. Journal of Sexual Medicine. 2010;7(4 PART 1).
97. Shindel AW, Xin ZC, Lin G, Fandel TM, Huang YC, Banie L, et al. Erectogenic and neurotrophic effects of icariin, a purified extract of horny goat weed (Epimedium spp.) in vitro and in vivo. Journal of Sexual Medicine. 2010;7(4 PART 1).
98. Zhang J, Li AM, Liu BX, Han F, Liu F, Sun SP, et al. Effect of icarisid II on diabetic rats with erectile dysfunction and its potential mechanism via assessment of AGEs, autophagy, mTOR and the NO-cGMP pathway. Asian Journal of Andrology. 2013;15(1).
98. Zhang J, Li AM, Liu BX, Han F, Liu F, Sun SP, et al. Effect of icarisid II on diabetic rats with erectile dysfunction and its potential mechanism via assessment of AGEs, autophagy, mTOR and the NO-cGMP pathway. Asian Journal of Andrology. 2013;15(1).
99. Zhang J, Wang YB, Ma CG, Liu T, Li WR, Gong YQ, et al. Icarisid II, a PDE5 inhibitor from Epimedium wanshanense, increases cellular cGMP by enhancing NOS in diabetic ED rats corpus cavernosum tissue. Andrologia. 2012;44(SUPPL.1).
99. Zhang J, Wang YB, Ma CG, Liu T, Li WR, Gong YQ, et al. Icarisid II, a PDE5 inhibitor from Epimedium wanshanense, increases cellular cGMP by enhancing NOS in diabetic ED rats corpus cavernosum tissue. Andrologia. 2012;44(SUPPL.1).
100. Li H, Jiang H, Liu J. Traditional Chinese medical therapy for erectile dysfunction. Vol. 6, Translational Andrology and Urology. 2017.
100. Li H, Jiang H, Liu J. Traditional Chinese medical therapy for erectile dysfunction. Vol. 6, Translational Andrology and Urology. 2017.
101. Li X zhu, Yan H dong, Wang J. Extract of Ginkgo biloba and alpha-lipoic acid attenuate advanced glycation end products accumulation and RAGE expression in diabetic nephropathy rats. 2011;31(4). 102. Muchtaromah B, Romaidi, Putri RE, Nuraini FD. Effect of mulberry (Morus alba L.) leaves infusion on the reproductive status of chronic diabetic models. Journal of Applied Environmental and Biological Sciences. 2015;5(5).
101. Li X zhu, Yan H dong, Wang J. Extract of Ginkgo biloba and alpha-lipoic acid attenuate advanced glycation end products accumulation and RAGE expression in diabetic nephropathy rats. 2011;31(4). 102. Muchtaromah B, Romaidi, Putri RE, Nuraini FD. Effect of mulberry (Morus alba L.) leaves infusion on the reproductive status of chronic diabetic models. Journal of Applied Environmental and Biological Sciences. 2015;5(5).
103. Ha US, Koh JS, Woo JC, Kim SJ, Kim SJ, Jang H, et al. The Effect of Cyanidin-3-O-β-d-glucopyranoside on the Penile Erection and Corpus Cavernosum in a Rat Model of Diabetic Erectile Dysfunction. Korean Journal of Andrology. 2011;29(2).
103. Ha US, Koh JS, Woo JC, Kim SJ, Kim SJ, Jang H, et al. The Effect of Cyanidin-3-O-β-d-glucopyranoside on the Penile Erection and Corpus Cavernosum in a Rat Model of Diabetic Erectile Dysfunction. Korean Journal of Andrology. 2011;29(2).
104. Khalifa I, Xia D, Dutta K, Peng J, Jia Y, Li C. Mulberry anthocyanins exert anti-AGEs effects by selectively trapping glyoxal and structural-dependently blocking the lysyl residues of β-lactoglobulins. Bioorganic Chemistry. 2020;96.
104. Khalifa I, Xia D, Dutta K, Peng J, Jia Y, Li C. Mulberry anthocyanins exert anti-AGEs effects by selectively trapping glyoxal and structural-dependently blocking the lysyl residues of β-lactoglobulins. Bioorganic Chemistry. 2020;96.
105. Aminyoto M, Ismail S. Penile erection responses of Nigella sativa seed extract on isolated rat corpus cavernosum. In: IOP Conference Series: Earth and Environmental Science. 2018.
105. Aminyoto M, Ismail S. Penile erection responses of Nigella sativa seed extract on isolated rat corpus cavernosum. In: IOP Conference Series: Earth and Environmental Science. 2018.
106. Balyan P, Khan J, Ali A. Therapeutic potential of Nigella sativa in the prevention of aggregation and glycation of proteins. In: Black Seeds (Nigella sativa): Pharmacological and Therapeutic Applications. 2021.
106. Balyan P, Khan J, Ali A. Therapeutic potential of Nigella sativa in the prevention of aggregation and glycation of proteins. In: Black Seeds (Nigella sativa): Pharmacological and Therapeutic Applications. 2021.
107. Awasthi S. Understanding the mechanism of antidiabetic activity and efficacy of functional foods against advanced glycation end products: Nigella sativa and Moringa oleifera. Planta Medica. 2013;79(13).
107. Awasthi S. Understanding the mechanism of antidiabetic activity and efficacy of functional foods against advanced glycation end products: Nigella sativa and Moringa oleifera. Planta Medica. 2013;79(13).
108. Rubab U, Kumar D, Farah MA, Al-Anazi KM, Ali MA, Ali A. Inhibitory Roles of Nigella sativa seed extracts on in vitro glycation and aggregation. Pharmacognosy Magazine. 2021;96.
108. Rubab U, Kumar D, Farah MA, Al-Anazi KM, Ali MA, Ali A. Inhibitory Roles of Nigella sativa seed extracts on in vitro glycation and aggregation. Pharmacognosy Magazine. 2021;96.
109. Yang C yong, Wang J, Zhao Y, Shen L, Jiang X, Xie Z guo, et al. Anti-diabetic effects of Panax notoginseng saponins and its major anti-hyperglycemic components. Journal of Ethnopharmacology. 2010;130(2).
109. Yang C yong, Wang J, Zhao Y, Shen L, Jiang X, Xie Z guo, et al. Anti-diabetic effects of Panax notoginseng saponins and its major anti-hyperglycemic components. Journal of Ethnopharmacology. 2010;130(2).
110. Uzayisenga R, Ayeka PA, Wang Y. Anti-diabetic potential of Panax notoginseng saponins (PNS): A review. Vol. 28, Phytotherapy Research. 2014.
110. Uzayisenga R, Ayeka PA, Wang Y. Anti-diabetic potential of Panax notoginseng saponins (PNS): A review. Vol. 28, Phytotherapy Research. 2014.
111. Tam SW, Worcel M, Wyllie M. Yohimbine: A clinical review. Vol. 91, Pharmacology and Therapeutics. 2001.
111. Tam SW, Worcel M, Wyllie M. Yohimbine: A clinical review. Vol. 91, Pharmacology and Therapeutics. 2001.
112. Onal E, Yilmaz D, Kaya E, Bastaskin T, Bayatli N, Gur S. Pomegranate juice causes a partial improvement through lowering oxidative stress for erectile dysfunction in streptozotocin-diabetic rat. International Journal of Impotence Research. 2016;28(6).
112. Onal E, Yilmaz D, Kaya E, Bastaskin T, Bayatli N, Gur S. Pomegranate juice causes a partial improvement through lowering oxidative stress for erectile dysfunction in streptozotocin-diabetic rat. International Journal of Impotence Research. 2016;28(6).
113. Maiorino MI, Bellastella G, Esposito K. Lifestyle modifications and erectile dysfunction: What can be expected? Vol. 17, Asian Journal of Andrology. 2015.
113. Maiorino MI, Bellastella G, Esposito K. Lifestyle modifications and erectile dysfunction: What can be expected? Vol. 17, Asian Journal of Andrology. 2015.
114. Rahimi HR, Arastoo M, Ostad SN. A comprehensive review of Punica granatum (Pomegranate) properties in toxicological, pharmacological, cellular and molecular biology researches. Vol. 11, Iranian Journal of Pharmaceutical Research. 2012.
114. Rahimi HR, Arastoo M, Ostad SN. A comprehensive review of Punica granatum (Pomegranate) properties in toxicological, pharmacological, cellular and molecular biology researches. Vol. 11, Iranian Journal of Pharmaceutical Research. 2012.
115. Zhang Q, Radisavljevic ZM, Siroky MB, Azadzoi KM. Dietary antioxidants improve arteriogenic erectile dysfunction. International Journal of Andrology. 2011;34(3).
115. Zhang Q, Radisavljevic ZM, Siroky MB, Azadzoi KM. Dietary antioxidants improve arteriogenic erectile dysfunction. International Journal of Andrology. 2011;34(3).
116. Yagi M, Mitsuhashi R, Wantanabe A, Moritani Y, Naito J, Lanny P et al. Cleaving effect of pomegranate (Punica granatum) extract on crosslink derived from advanced glycation endproducts. Glycative Stress Research. 2015;2.
116. Yagi M, Mitsuhashi R, Wantanabe A, Moritani Y, Naito J, Lanny P et al. Cleaving effect of pomegranate (Punica granatum) extract on crosslink derived from advanced glycation endproducts. Glycative Stress Research. 2015;2.
117. Do J, Choi S, Choi J, Hyun JS. Effects and mechanism of action of a Tribulus terrestris extract on penile erection. Korean Journal of Urology. 2013;54(3).
117. Do J, Choi S, Choi J, Hyun JS. Effects and mechanism of action of a Tribulus terrestris extract on penile erection. Korean Journal of Urology. 2013;54(3).
118. Zhu W, Du Y, Meng H, Dong Y, Li L. A review of traditional pharmacological uses, phytochemistry, and pharmacological activities of Tribulus terrestris. Vol. 11, Chemistry Central Journal. 2017.
118. Zhu W, Du Y, Meng H, Dong Y, Li L. A review of traditional pharmacological uses, phytochemistry, and pharmacological activities of Tribulus terrestris. Vol. 11, Chemistry Central Journal. 2017.
119. Zhang H, Tong WT, Zhang CR, Li JL, Meng H, Yang HG, et al. Gross saponin of Tribulus terrestris improves erectile dysfunction in type 2 diabetic rats by repairing the endothelial function of the penile corpus cavernosum. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2019;12.
119. Zhang H, Tong WT, Zhang CR, Li JL, Meng H, Yang HG, et al. Gross saponin of Tribulus terrestris improves erectile dysfunction in type 2 diabetic rats by repairing the endothelial function of the penile corpus cavernosum. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2019;12.
120. Gauthaman K, Ganesan AP. The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction - an evaluation using primates, rabbit and rat. Phytomedicine. 2008;15(1–2).
120. Gauthaman K, Ganesan AP. The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction - an evaluation using primates, rabbit and rat. Phytomedicine. 2008;15(1–2).
121. Figueiredo CCM, da Costa Gomes A, Granero FO, Bronzel Junior JL, Silva LP, Ximenes VF, et al. Antiglycation and antioxidant activities of the crude extract and saponin fraction of Tribulus terrestris before and after microcapsule release. Journal of Integrative Medicine. 2022;20(2).
121. Figueiredo CCM, da Costa Gomes A, Granero FO, Bronzel Junior JL, Silva LP, Ximenes VF, et al. Antiglycation and antioxidant activities of the crude extract and saponin fraction of Tribulus terrestris before and after microcapsule release. Journal of Integrative Medicine. 2022;20(2).
122. Ștefănescu R, Tero-Vescan A, Negroiu A, Aurică E, Vari CE. A comprehensive review of the phytochemical, pharmacological, and toxicological properties of tribulus terrestris l. Vol. 10, Biomolecules. 2020.
122. Ștefănescu R, Tero-Vescan A, Negroiu A, Aurică E, Vari CE. A comprehensive review of the phytochemical, pharmacological, and toxicological properties of tribulus terrestris l. Vol. 10, Biomolecules. 2020.