The Comparison of Imipramine and Desmopressin (DDAVP) Long-Term Therapy Results in Adult Enuresis Nocturna The long-term therapy results of Imipramine and Desmopressin were compared in 35 adult patients with monosymptomatic enuresis nocturna. Randomly selected 17 patients were treated with 1 mg/kg oral Imipramine and 18 with 20 pg intranasal Desmopressin nightly for three months. Dose titration was done for Desmopressin monthly. Complete improvoment rates in the Desmopressin group were 55%, 61% and 72% after the first, the second and the third months respectively, whereas in the Imipramine group these were found 23%, 40% and 47 %, respectively. The difference between the improvement rates of two groups were not statistically significant (p>0.05). Three months after the end of therapy, complete improvement rates were 30% and 28% for Desmopressin and Imipramine respectively. Relaps rates were 61% in the Desmopressin group and 30% in the Imipramine group (p0.05). Tedavi kesildikten 3 ay sonra tam iyileşme oranlan dezmopressin için %30 ve imipramin için %28 bulundu. Rölaps oranlan ise dezmopressin için %61 ve imipramin için %30 idi (p