Intramuscular meperidine analgesia at the beginning of active phase shortens labor duration without adverse effects on obstetric lacerations and neonatal outcomes
Objective: The primary objectives of this study were to evaluate the impact of intramuscular meperidine on shortening of the active phase of labor, the neonatal outcome and the rate and severity of perineal lacerations in term pregnant women in the first stage of labor.
Materials and Methods: A total of 571 primiparous term pregnant women delivered vaginally were included into this retrospective study. In 437 of them, meperidine (100 mg IM) at the beginning of the active phase was administered and 134 women did not receive any meperidine dose. The length of labor phases, obstetric lacerations, and neonatal outcomes were recorded.
Results: The results of this study showed that meperidine could be used safely as an obstetric analgesic with its additional benefit of shortening the active phase of the first stage and second stage of labor without increased risk of obstetric lacerations and perinatal adverse outcomes.
Conclusions: In case of limited use of neuroaxil analgesia in a busy state maternity hospital, intramuscular meperidine administration as obstetric analgesia seems beneficial in reducing the length of the active phase of the first stage of labor and the second stage of labor without adversely affecting obstetric lacerations and neonatal outcomes.
Keywords:
obstetric analgesia, meperidine, normal vaginal delivery, stages of labor, obstetric lacerations, neonatal outcome,
___
- Aburel E. L'anesthésie locale continue (prolongée) en obstétrique. Bull Soc Obstet Gynecol 1931; 20: 35-37.
- ACOG Committee Opinion 295: pain relief during labor. Obstet Gynecol. 2004; 104: 213.
- Allman KG, Wilson H, and O’Donnel A. Chapter 41 Regional anaesthesia. In: Oxford Handbook of Anaesthesia. 2006: 1120.
- Berghella V, Baxter JK, Chauhan SP. Evidence-based labor and delivery management. Am J Obstet Gynecol. 2008; 199: 445-454.
- Caton D. The History of Obstetric Anesthesia. In: Chestnut’s Obstetric Anesthesia: Principles and Practice. 2009; 114: 1326–1331.
- Kominiarek MA, Zhang J, VanVeldhuisen P, Troendle J, Beaver J, Hibbard JU. Contemporary labor patterns: the impact of maternal body mass index. Am J Obstet Gynecol. 2011; 205: 244-244.
- Lang AJ, Sorrell JT, Rodgers CS, Lebeck MM. Anxiety sensitivity as a predictor of labor pain. Eur J Pain. 2006; 10: 263-70.
- Latta KS, Ginsberg B, Barkin RL. Meperidine: A Critical Review. Am J Ther . 2002; 9: 53-68.
- Leduc D, Biringer A, Lee L, Dy J “Induction of labour: SOGC Clinical Practice Guideline. J Obs Gynaecol Can. 2013; 35: 840-857.
- Macarthur AJ, Macarthur C. Incidence, severity, and determinants of perineal pain after vaginal delivery: A prospective cohort study. Am J Obstet Gynecol. 2004; 191: 1199-204.
- Maronge L, Bogod D. Complications in obstetric anaesthesia. Anaesthesia. 2018; 73: 61–66.
- Millen KR, Kuo K, Zhao L, Gecsi K. Evidence-based guidelines in labor management. Obstetrical and Gynecological Survey. 2014; 69: 209–217.
- Mizrachi, Y., Leytes, S., Levy, M., Ginath, S., Bar, J., Ezri, T., Kovo, M. Does meperidine analgesia affect the incidence of obstetric lacerations at vaginal delivery?. J Matern Fetal Neonatal Med 2017: 1-5.
- Munro A, George RB. Chestnut’s Obstetric Anesthesia Principles and Practice, Fifth Edition. Can J Anesth Can d’anesthésie. 2015; 62: 1027–1028.
- Nissen E, Widström AM, Lilja G, et al., Effects of routinely given pethidine during labour on infants’ developing breastfeeding behaviour. Effects of dose-delivery time interval and various concentrations of pethidine/norpethidine in cord plasma. Acta Paediatr. 1997; 86: 201–8.
- Oliveira MRE, Santos MG, Aude DA,et al. [Should maternal anesthesia delay breastfeeding? A systematic review of the literature]. Rev Bras Anestesiol. 2019; 69: 184–96.
- Pillai A, Bogod D. Chestnut′s Obstetric Anesthesia: Principles and Practice. Br J Anaesth. 2015; 114: 861.
- Shnider SM, Moya F. Effects of meperidine on the newborn infant. Am J Obstet Gynecol. 1964; 15, 89: 1009–1015.
- Tita ATN, Rouse DJ. Obstetric Management of Labor and Vaginal Delivery. In: Chestnut’s Obstetric Anesthesia: Principles and Practice. 2009: 223-245.
- Ullman R, Smith LA, Burns E, Mori R, Dowswell T. Parenteral opioids for maternal pain management in labour. Cochrane Database Syst Rev. 2010; 9: CD007396.
- Viktrup L. The risk of lower urinary tract symptoms five years after the first delivery*. Neurourol Urodyn [Internet]. 2002; 21: 2–29.
- Wood A. Treatment of Neuralgic Pains by Narcotic Injections. Br Med J. 1858; 28: 721-723.
- Zakowski MI, Herman NL. The Placenta: Anatomy, Physiology, and Transfer of Drugs. In: Chestnut’s Obstetric Anesthesia: Principles and Practice. 2009; 4: 55-68.
- Yayın Aralığı: Yılda 4 Sayı
- Başlangıç: 1980
- Yayıncı: Ondokuz mayıs Üniversitesi Tıp Fakültesi
Sayıdaki Diğer Makaleler
Yeliz TANRIVERDİ ÇAYCI, İlknur BIYIK, Gonca YILMAZ, Kemal BİLGİN, Asuman BIRINCI
Serdar ÖZDEMİR, Abdullah ALGIN, Hatice Şeyma AKÇA, Mehmet ERDOĞAN
Ayşe GÜRESER, Derya YAPAR, Özlem AKDOĞAN, Ayşegül TAYLAN ÖZKAN, Nurcan BAYKAM
Hatice Şeyma AKÇA, Mehmet Muzaffer İSLAM, Uğur Yasin AKGÜN, Serdar ÖZDEMİR, Abdullah ALGIN, Serkan Emre EROĞLU
Korkut BOZAN, Abdullah ALGIN, Serdar ÖZDEMİR, Mehmet ERDOĞAN, Nazmiye KOYUNCU, Özgür KARCIOĞLU
Nur DOKUZEYLÜL GÜNGÖR, Arzu YURCİ, Tuğba GÜRBÜZ, Kağan GÜNGÖR
A Rare Case: Covid-19 Infection Diagnosed by Transthoracic Fine Needle Aspiration Biopsy
Tuğçe ŞAHİN ÖZDEMİREL, Esma Sevil Akkurt AKKURT, Özlem ERTAN, Hakan NOMENOGLU, Sadi KAYA, Berna AKINCI ÖZYÜREK
Ehsan DOWLATSHAHİ, Shahdad KHOSROPANAH, Mehdi KALANİ, Mehrnoosh DOROUDCHİ