Dursun Mehmet MEHEL, Gökhan AKGÜL, Doğukan ÖZDEMİR, Mehmet ÇELEBİ, Nesrettin Fatih TURGUT, Samet AYDEMİR, Abdulkadir ÖZGÜR

2923

Neck metastasis in transglottic laryngeal carcinomas

In laryngeal cancers, the first metastasis occurs in the cervical lymph nodes This study aimed to determine the levels of cervical metastatic lymph nodes in patients with transglottic laryngeal carcinoma, the effect of tumor prognostic factors on cervical lymph node metastasis. The research retrospectively examined 32 patients who underwent total laryngectomy and neck dissection, with the diagnosis of transglottic squamous cell carcinoma (SCC). Age, gender, complaint, smoking status, and other prognostic factors were evaluated. All patients underwent total laryngectomy with 63 neck dissections. Seven patients had metastatic cervical lymph nodes. Among the prognostic factors, thyroid cartilage invasion, combined perineural–perivascular invasion, subglottic extension, extralaryngeal extension, and preoperative tracheotomy procedure had statistically significant effects on neck metastasis. In conclusion; Dissection at level IIB should be reassessed to decrease morbidity due to the low prevalence of level IIB metastasis, both clinically and pathologically. In locally advanced laryngeal cancers, considering the prognostic factors, it is ideal to plan specific treatments for each patient.
Keywords:

Transglottic laryngeal carcinoma, level IIB, cervical metastasis, prognostic factors.,

PDF

___

  • 1. Mendenhall WM, Werning JW, Hinerman RW, Amdur RJ, Villaret DB. Management of T1-T2 glottic carcinomas. Cancer. 2004 May 1;100(9):1786-92.
  • 2. Hoffman HT, Porter K, Karnell LH, Cooper JS, Weber RS, Langer CJ, Ang KK, Gay G, Stewart A, Robinson RA. Laryngeal cancer in the United States: changes in demographics, patterns of care, and survival. Laryngoscope. 2006 Sep;116(9 Pt 2 Suppl 111):1-13.,
  • 3. Bailey BJ. Glottic carcinoma. In: Bailey BJ, Biler HF, editors. Surgery of larynx. Philadelphia: WB Saunders Comp; 1985, p.257.
  • 4. Mendenhall WM, Werning JW. Early-stage cancer of the larynx. Part A: general principles and management. In: Harrison LB, Sessions RB, Hong WK, editors. Head and Neck Cancer: a multidisciplinary approach, 3rd edition. Philadelphia: Lippincott Williams & Wilkins 2009, p.339–353.
  • 5. Alvi A, Johnson JT. Extracapsular spread in the clinically negative neck (N0): implications and outcome. Otolaryngol Head Neck Surg. 1996 Jan;114(1):65-70.
  • 6. Gallo O, Deganello A, Scala J, De Campora E. Evolution of elective neck dissection in N0 laryngeal cancer. Acta Otorhinolaryngol Ital. 2006 Dec;26(6):335-44.
  • 7. Pitman KT, Johnson JT, Myers EN. Effectiveness of selective neck dissection for management of the clinically negative neck. Arch Otolaryngol Head Neck Surg. 1997 Sep;123(9):917-22. 8. Taylor RJ, Chepeha JC, Teknos TN, Bradford CR, Sharma PK, Terrell JE, Hogikyan ND, Wolf GT, Chepeha DB. Development and validation of the neck dissection impairment index: a quality of life measure. Arch Otolaryngol Head Neck Surg. 2002 Jan;128(1):44-9.
  • 9. Gallo A, Manciocco V, Simonelli M, Pagliuca G, D'Arcangelo E, de Vincentiis M. Supracricoid partial laryngectomy in the treatment of laryngeal cancer: univariate and multivariate analysis of prognostic factors. Arch Otolaryngol Head Neck Surg. 2005 Jul;131(7):620-5.
  • 10. Bradford CR, Ferlito A, Devaney KO, Mäkitie AA, Rinaldo A. Prognostic factors in laryngeal squamous cell carcinoma. Laryngoscope Investig Otolaryngol. 2020 Jan 27;5(1):74-81.
  • 11. Shah J, Patel S. Head and Neck surgery and oncology. 3th ed. Edingurg, London, New York, Toronto:Mosby; 2003; 353-94.
  • 12. Chepeha DB, Taylor RJ, Chepeha JC, Teknos TN, Bradford CR, Sharma PK, Terrell JE, Wolf GT. Functional assessment using Constant's Shoulder Scale after modified radical and selective neck dissection. Head Neck. 2002 May;24(5):432-6.
  • 13. Muzaffar K. Therapeutic selective neck dissection: a 25-year review. Laryngoscope. 2003 Sep;113(9):1460-5.
  • 14. Mnejja M, Hammami B, Bougacha L, Chakroun A, Charfeddine I, Khabir A, Boudaoura T, Ghorbel A. Occult lymph node metastasis in laryngeal squamous cell carcinoma: therapeutic and prognostic impact. Eur Ann Otorhinolaryngol Head Neck Dis. 2010 Nov;127(5):173-6.
  • 15. Gross BC, Olsen SM, Lewis JE, Kasperbauer JL, Moore EJ, Olsen KD, Price DL. Level IIB lymph node metastasis in laryngeal and hypopharyngeal squamous cell carcinoma: single-institution case series and review of the literature. Laryngoscope. 2013 Dec;123(12):3032-6.
  • 16. Sezen OS, Kubilay U, Haytoglu S, Unver S. Frequency of metastases at the area of the supraretrospinal (level IIB) lymph node in laryngeal cancer. Head Neck. 2007 Dec;29(12):1111-4..
  • 17. Yilmaz T, Hosal AS, Gedikoğlu G, Onerci M, Gürsel B. Prognostic significance of vascular and perineural invasion in cancer of the larynx. Am J Otolaryngol. 1998 Mar-Apr;19(2):83-8.
  • 18. Aydın Y, Paltura C, Tetik F, Kımıloğlu E, Külekçi M. The Relationship Between Local Properties and Neck Metastasis. Jarem. 2018; 8:191-7.
  • 19. Bai W, Ji W, Ren Z. [Relationship between the local invasion and the lymph node metastasis of the supraglottic carcinoma]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008 Feb;22(4):163-5.
  • 20. Lucioni M, D'Ascanio L, De Nardi E, Lionello M, Bertolin A, Rizzotto G. Management of paratracheal lymph nodes in laryngeal cancer with subglottic involvement. Head Neck. 2018 Jan;40(1):24-33.
  • 21. Ozagaç A, Akın I, Erdoğan M, Celik H, Kaplan T, Eroglu S. Correlation of clinical and histopathological parameters to survival and neck metastasis in laryngeal squamous cell carcinoma. K.B.B. ve BBC Dergisi. 2002; 10:42-7.
  • 22. Skóra T, Nowak-Sadzikowska J, Mucha-Małecka A, Szyszka-Charewicz B, Jakubowicz J, Gliński B. Postoperative irradiation in patients with pT3-4N0 laryngeal cancer: results and prognostic factors. Eur Arch Otorhinolaryngol. 2015 Mar;272(3):673-9.
  • 23. Kennedy WR, Amdur RJ, Boyce BJ, Dziegielewski P, Morris CG, Mendenhall WM. Neck Management with Total Laryngectomy and Adjuvant Radiotherapy in Locally Advanced Larynx Cancer. Oncol Res Treat. 2017;40(9):503-506.
Journal of Experimental and Clinical Medicine-Cover
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1980
  • Yayıncı: Ondokuz mayıs Üniversitesi Tıp Fakültesi
Arşiv
Sayıdaki Diğer Makaleler

Batuhan GENCER, Özgür DOĞAN

Ezgi KÜRKÇÜ KAHRAMAN, Nurettin AYDOĞDU, Hakan ERBAŞ

Osman Samet GÜNKAYA, Ozge YASSA, Arzu TEKİN, Meltem TEKELIOGLU, Goktug UMUR, Oguz ARSLAN, Zeynep GEDİK ÖZKÖSE, Üzeyir KALKAN, Nıyazı TUG

Şebnem ALANYA TOSUN, Muhammet BULUT, Aysegul CEBİ, Sema BAKİ YILDIRIM

Nergis EKMEN, Nirgül BİLGER, Derya KİRMAN, Hadi SASANİ

Berat Serdar AKDENİZ, Yunus ÇARPAR, Kübra ARSLAN ÇARPAR

Servet ŞEKERYAPAN ÇALIKOĞLU, Melike DOĞANAY, Duygu TUĞRUL ERSAK, Burak ERSAK, Mahmut Kuntay KOKANALI

Burak ERSAK, Mahmut Kuntay KOKANALI, Duygu TUGRUL ERSAK, Yüksel OĞUZ, Yasemin TAŞÇI

Zehra YILMAZ, Canan SOYER ÇALIŞKAN, Nur DOKUZEYLÜL GÜNGÖR, Merve YILMAZ, Samettin ÇELİK, Sebahattin ÇELİK

Özlem AKDOĞAN, Derya YAPAR, Kazım ÇEBİ, Sertaç ARSLAN, Hilal BOYACI, Yasemin ARI YILMAZ, Pınar TUNÇEL ÖZTÜRK, Ünsal SAVCI, Hüseyin KAYADİBİ, Ayşe YILMAZ, Meral GÜLHAN, Aysel KOCAGÜL ÇELİKBAŞ, Nurcan BAYKAM