Celiac disease in an obese child with down syndrome
Patients with Down syndrome are predisposed to autoimmune disease and havea higher risk for type 1 diabetes, autoimmune thyroid disorders, alopecia, vitiligo,hypoparathyroidism and celiac disease. Diarrhea and malabsorption representthe typical presentation of celiac disease, while obesity or weight gain areuncommon in young children. We report an 8-year-old obese girl with Downsyndrome who was diagnosed as celiac disease in the absence of signs andsymptoms. We would suggest that even in absence of signs and symptoms, thechildren with Down syndrome should be screened annually for celiac disease
even owing to obesity.
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- Kinik, S.T., Ozcay, F., Varan, B., 2006. Type I diabetes mellitus, Hashimoto’s thyroiditis and celiac disease in an adolescent with
Down syndrome. Pediatr. Int. 48, 433-435.
Book, L., Hart, A., Black., J., Feolo, M., Zone, J.J., Neuhausen, S.L., 2001. Prevalence and clinical characteristics of celiac disease
in Down syndrome in a US study. Am. J. Med. Genet. 98, 70-74.
Cogulu, O., Ozkinay, F., Gunduz, C., Cankaya, T., Aydogdu, S., Ozgenc, F., Kutukculer, N., Ozkinay, C., 2003. Celiac disease in
children with Down syndrome: importance of following up and serological screening. Pediatr. Int. 45, 395-359.
George, E.K., Mearin, M.L., Bouquet, J., von Blomberg, B.M., Stapel, S.O., van Elburg, R.M., de Graaf, E.A., 1996. High frequency
of celiac disease in Down syndrome. J. Pediatr. 128, 555-557.
Jansson, U., Johansson, C., 1995. Down syndrome and celiae disease. J. Pediatr. Gastroenterol. Nutr. 21, 443-445.
Arslan, N., Esen, I., Demircioglu, F., Yilmaz, S., Unuvar, T., Bober, E., 2009. The changing face of celiac disease: A girl with
obesity and celiac disease. J. Paediatr. Child Health. 45, 317-318. doi: 10.1111/j.1440-1754.2009.01512.x.
Balamtekin, N., Demir, H., Baysoy, G., Uslu, N., Yüce, A., 2011. Obesity in adolescents with celiac disease: Two adolescents and
two different presentations. Turk J. Pediatr. 53, 314-316.
Conti, Nibali, S., Magazzù, G., De Luca, F., 1987. Obesity in a child with untreated coeliac disease. Helv. Paediatr. Acta. 42, 45-48.
Venkatasubramani, N., Telega, G., Werlin, S.L., 2010. Obesity in pediatric celiac disease. J. Pediatr. Gastroenterol. Nutr. 51, 295-
297. doi: 10.1097/MPG.0b013e3181d1365a.
Semeraro, L.A., Barwick, K.W., Gryboski, J.D. 1986. Obesity in celiac sprue. J. Clin. Gastroenterol. 8, 177-180.