TİROİD UYARICI HORMON, SERBEST TİROKSİN SEVİYELERİ VE TİROİD ANTİKORLARININ ORTALAMA TROMBOSİT HACMİ ÜZERİNDEKİ ETKİLERİ: ORİJİNAL ARAŞTIRMA

Giriş: Tiroid hormonlarının metabolizması bozulmuş hastalarda pıhtılaşma anormallikleri bildirilmiştir. Trombositler pıhtılaşmada önemli bir rol oynar ve Ortalama Trombosit Hacmi (MPV), birçok hastalıkta inflamatuar bir biyobelirteç olarak kabul edilir. Amaç: Bu çalışmanın amacı, tiroid uyarıcı hormon, serbest tiroksin, anti-tiroid peroksidaz ve anti-tiroglobulin değerleri ile MPV değerleri arasında herhangi bir ilişki olup olmadığını araştırmaktı. Yöntemler: Endokrinoloji polikliniğine Ekim 2013 - Temmuz 2019 tarihleri arasında tiroid hastalığı ön tanısıyla başvuran hastalar dahil edildi. Veriler IBM SPSS V23 ile analiz edildi. Normal dağılıma uyumluluk Shapiro Wilk testi ile incelendi. Değişkenler arasındaki ilişki Spearman sıra korelasyonu ile değerlendirildi. Bulgular: 1098 hastanın kayıtları incelendi. TSH ile MPV arasında çok zayıf bir pozitif ilişki vardı (r: 0,075), ST4, Anti TPO, Anti TG ve MPV arasında anlamlı bir ilişki yoktu. Sonuç: Yüksek TSH değerlerine sahip hastalarda yüksek MPV değerleri görülmekte olup trombotik olayların risk tahmini yapılabilir.

Anahtar Kelimeler:

Tiroid hormonları, Ortalama trombosit hacmi, Tiroid hastalığı

THE EFFECTS OF THYROID-STIMULATING HORMONE, FREE THYROXINE LEVELS, AND THYROID ANTIBODIES ON MEAN PLATELET VOLUME: ORIGINAL RESEARCH

Background: Coagulation abnormalities has been reported in patients with impaired metabolism of thyroid hormones. Platelets play an important role in coagulation and Mean Platelet Volume has been considered as an inflammatory biomarker in multiple diseases. Objectives: The aim of this study was to investigate whether any relationship exists between the values of thyroid-stimulating hormone, free thyroxine, anti-thyroid peroxidase, anti-thyroglobulin and those of the MPV. Methods: Patients who were admitted to the Endocrinology outpatient clinic between October 2013 and July 2019 with a pre-diagnosis of thyroid disease were included in the study. The data were analyzed with IBM SPSS V23. Compatibility with normal distribution was examined with the Shapiro Wilk test. The relation between the variables was evaluated with Spearman rank correlation. Results: Records of 1098 patients were examined. There is a very weak positive relationship between TSH and MPV (r: 0,075), there is no significant relationship between ST4, Anti TPO, Anti TG and MPV. Conclusion: Patients have high TSH values display a increased MPV should hence be acknowledged in risk prediction of thrombotic events.

Keywords:

Thyroid hormones, Mean platelet volume, THYROID DISEASE,

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