Demet ALAYGUT, Mehtat UNLU, Semih SUTAY, Özkan KARAMAN, Özden ANAL

Adenoid doku CD23 (FcεRII) ekspresyonu: Çocuklarda tekrarlayan üst solunum yolu enfeksiyonu yakınmaları ve allerji temelinde bir değerlendirme

Amaç: Bu çalışmada, CD23, IgE\'nin düşük afiniteli reseptörü immunohistokimyasal yöntemle değerlendirildi ve üst solunum yolu enfeksiyonu ve alerji semptomlarının varlığına göre analiz edildi. Yöntemler: Bu retrospektif çalışmaya yaşları 2-13 yaş arasında değişen adenoidekromi ve adenoidektomi/ tonsillektomi operasyonu geçiren 100 hasta alındı. Patoloji raporları lenfoid hiperplazi ve kronik enfeksiyon şeklinde olanlar çalışmaya dahil edildi. Immunohistokimyasal olarak CD23 ekspresyonu semikantitatif metodla (0-3) arasında değerlendirildi. Bulgular: Çalışma grubunun ortalama yaşı 70,7 ay, % 46\'sı kız hastalardan oluşmaktaydı ve hastaların % 30\'u sadece adenoidektomi operasyonu geçirmişti. Operasyon sonrası, enfeksiyon sıklığı % 91 oranında azalmakla birlikte, alerji semptomları %84 oranında değişmemişti. CD23 ekspresyonu özellikle ürtiker yakınması olanlarda (p=0,037), ilaç alerjisi olanlarda (p= 0.035) ve polen alerjisi (p= 0.041) olanlarda anlamlı olarak düşük bulundu. Sonuç: Atopik hastalarda adenoid dokuda CD23 yüzey ekspresyonunun azalacağı tezini destekler şekilde ürtiker, ilaç allerjisi ve polen allerjisi olan hastalarda CD23 yoğunluğunu anlamlı olarak azalmış saptandı. Bu sonuçlar, adenoidektomiye rağmen tekrarlayan solunum yolu semptomları olan çocuklarda altta yatan mekanizmayı açıklamak açısından değerlendirilebilir.

Anahtar Kelimeler:

CD23 ekspresyonu, adenoid doku, atopi

Adenoidal tissue expression of CD23: An evaluation with reference to recurrent upper respiratory tract complaints and allergy in children

Objective: In this study, CD23, low affinity immunoglobulin E receptor, expression in the adenoid tissue was investigated immunohistochemically and evaluated with regard to upper respiratory tract infection complaints and allergy. Methods: This retrospective study was performed by the selection of 100 patients aged 2-13 years who underwent adenoidectomy/adenotonsillectomy and in whom the adenoid tissue pathological studies were reported as âlymphoid hyperplasia and chronic infectionâ were evaluated. Immunohistochemical evaluation of CD23 expression was scored semiquantitatively between 0-3 in the tissue samples. Results: The mean age in the study group was 70.7 months; 46% were female; 30% of patients had adenoidectomy only. Following the operation, the infection frequency decreased in 91% of patients, whereas allergy symptoms were unchanged in 84%. CD23 expression was found significantly lower in patients who had allergic manifestations, namely urticaria (p=0.041), drug sensitivity (p=0.035) and pollen allergy (p=0.037). Conclusion: A significantly reduced CD23 expression was found in adenoidal tissue in patients with allergic symptoms. These results can be assessed as an underlying mechanism for the recurrence of respiratory tract complaints in these children, despite adenoidectomy. J Clin Exp Invest 2013; 4 (1): 1-7

Keywords:

CD23 expression, adenoid tissue, atopy,

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