Şamil ÖZTÜRK, Suat ÇAKINA, Hayrunnisa YEŞİL, M. İbrahim TUĞLU

SPERMATOGENEZİS VE DİNAMİK KÖK HÜCRELER

Kök hücreler kendilerini sürekli yenileyebilme yetenekleri ve vücudumuzda bulunan hemen tüm erişkin hücrelere dönüşebilme yetenekleri ile muazzam bir terapötik potansiyele sahiptirler. Erkek üreme sisteminde dinamik bir kök hücre grubu sürekli çoğalarak infertilite oluşumunu engellemektedir. Bu süreç memelilerde spermatogenezis olarak adlandırılır ve testis seminifer tübüllerinde gerçekleşir. Germ kök hücreleri (GKH) olarak adlandırılan testis kök hücreleri, erişkinlik hayatı boyunca kendini yenileme ve hasarlanma sonrası hızlı rejenerasyon yeteneğine sahiptirler. Erkek üreme sisteminin vazgeçilmez unsuru olan ve bir sonraki neslin devamı için gerekli olan süreçte spermatogenezin dinamik bir şekilde yaşlılığın ilerleyen dönemine kadar nasıl gerçekleştiği? Her zaman sorulan ve yanıtı aranan soru olmuştur. Derleme çalışmamızda seminifer tübüllerde mitozla çoğalan spermatogonyumların mayozla spermatid oluncaya kadar ki değişimleri ve kök hücre rezervleri ele alınmıştır.

Anahtar Kelimeler:

Germ kök hücreleri, Sprematogonyum, Spermatogenezis

SPERMATOGENESİS AND DYNAMİC STEM CELLS

Stem cell shave a tremendous therapeutic potential with their ability to continually renew themselves and their ability to transform into almost all mature cells in our body. In the male reproductive system, a dynamic group of stem cells proliferates and prevents in fertility. This process is called spermatogenesis in mammals and the testis occurs in seminiferous tubules. Testicular stem cells, called germ stem cells (GKH) are capable of rapid regeneration after self-renewal and injury during adult life. How did spermatocytes occur dynamically in the later stages of old age? which is an indispensable element of the male reproductive system and is necessary for the continuation of the next generation. There has always been a question I asked and the answer was sought. In our review study, the changes of spermatogonium proliferating with mitosis in seminiferous tubules up to spermatozoa with meiosis and stem cell reserves are discussed.

Keywords:

Germ stem cells, Spermatogonium, Spermatogenesis.,

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