The present study investigated the effects of ethanol extract obtained from Punica granatum (Pge) on the longevity of Drosophila melanogaster Meigen. The effects of different concentrations of Pge (10.0; 30.0; 50.0 and 100.0mg/mL) were administered separately to female and male populations of D. melanogaster for the control and Pge groups. In all application groups, each population’s longevity increased, depending on the concentration of Pge. These findings demonstrate that the constituents of P. granatum have great potential as a source for natural health products for D. melanogaster management