Karun Riverian Iranian important source of water which has a dramatic decline in water quality in the last 10 years because of the discharge of wastewater. Recently pollution level in this river has raised and it caused environmental hazards for aquatic organisms. Because the fish are biological indicators, In this study, immune factors of common carp (Cyprinus carpio) was evaluated in two area sAhvaz (pollution) and Shoushtar (non-polluted), in two seasons Autumn 2010 (low water) and spring 2011(high water). 62 samples of common carp with the average weight 245±24 g and total length of 23±8 cm were captured. After adaptation, blood samples were collected and immune factors, including lysozyme activity, total protein, albumin, and serum bactericidal activity was examined. Our results showed that total protein rate, lysozyme activity, and albumin in Ahwaz sample has significant difference (P<0.05) compared to Shoushtar sample. While, serum bactericidal activity showed that seasons had no significant impact on factors (P>0.05). Moreover there was no significant difference in male and female sex (P>0.05)