The aim of the present investigation was aimed to evaluate the comparative study efficacy of different medicaments on postpartum anestrus dairy cows. The study was conducted on forty eight Friesian cows. The true anestrous cows (Experiment 1, n=32) were randomly allocated into four equal groups of 8 cows each according to the design of treatment; group 1served as a control without treatment; group2 received progesterone (CIDR for 10 days plus i.m. injection of 2ml Estrumate (PGF2α); group 3 received Lugol᾽s iodine solution and massage; group 4 treated with one injection of GnRH. The suboestrus cows (experiment 2, n=16) were divided into two equal groups. Group 1served as a control without treatment (n=8); group2 (PGF2α group, n=8) were treated by one injection of 2ml Estrumate (synthetic PGF2α). Fertility measures including the incidence, the mean interval between ends of the treatment to onset of estrus, the number of service per conception and pregnancy rates were recorded. Results showed that, the highest incidence of estrus (87.5%) and pregnancy rates (85.7%) were achieved with treatment of CIDR followed by Lugol᾽s solution plus massage and GnRH treatment regime where, the incidence of the estrus and pregnancy rates were (62.5,50.0;50.0, 40.0%, respectively). One of the eight control animals in treatment came into heat (12.5%) at an average post treatment interval of 480.0±22.4 hours and no animal was pregnant. The incidences of estrus and pregnancy rates of suboestrus cows after PGF2α treatment were 87.5% and 71.42%, respectively. While, in control group (experiment 2) no animal came in heat or pregnancy. In conclusion, CIDR for 10 days plus i.m. injection of 2ml PGF2α (Estrumate) was the most effective treatment of smooth inactive ovary. Other regimens such as Lugol᾽s solution and uterine as well as ovarian massage could be considered. Moreover, PGFα administration appeared to be efficient in treatment of suboestrus cows