Sefayet KARACA, Mehmet KARACA, Ayşe KAYMAZ

76109

A Study of Cancer-Related Genes: Prevalence of Polymorphic GSTT1 and GSTM1 Deletions in Turkey

A Study of Cancer-Related Genes: Prevalence of Polymorphic GSTT1 and GSTM1 Deletions in Turkey

The major burden of cancer in the general population is results from the complex interactions of multiple genetic and environmental factors over time. Population based studies support the involvement of GSTM1 and GSTT1 deletion in susceptibility to commonly occurring forms of cancer. The aim of this study was to determine frequency of GSTM1 and GSTT1 deletion variants in Turkish population. Deletion polymorphisms were screened in a collection of samples n=507 for GSTM1 and n=464 for GSTT1. After isolation of DNAs from whole blood, sequences of interest were amplified and then analyzed by electrophoretic methods in the presence of positive and negative controls. Allele frequencies were detected as 52% for GSTM1 and 24% for GSTT1 deletion polymorphisms. The obtained frequencies were consistent with the values that reported for different populations. Cancer is a disease of the genome and identification of the genetic characteristics of healthy individuals is important in determining of current risks, developing of preventive health care models and medical follow-up programs to reducing risk of diseases. However, during the treatment process it allows the selection of optimal therapy
Keywords:

cancer genetics, GSTM1 and GSTT1 deletions,

PDF
Journal of Applied Biological Sciences-Cover
  • ISSN: 1307-1130
  • Yayın Aralığı: 6
  • Başlangıç: 2007
  • Yayıncı: Nobel Bilim ve Araştırma Merkezi
Arşiv
Sayıdaki Diğer Makaleler

Characterization of Cathlelicidin gene in river buffalo

Ahlam A. ABOU MOSSALLAM, Eman R. MAHFOUZ, Nevien M. SABRY, Soheir M. El NAHAS

RFL polymorphism of three fertility genes in Egyptian buffalo

Othman E. OTHMAN, Mohamed F. ABDEL-SAMAD

Effect of Oxytetracycline and Florfenicol on the Cytogenetic Picture of Nile Tilapia

Abdel-Karim I.M. EL-SAYED, Magdi A. SOLTAN, Hasnaa A. RADWAN, Mona G. MOHAMED

Some Blood Parameters of Albino and Normal Pigmented Rainbow Trout with Short Term Exposure to a Bath of Malachite Green

Mustafa Erkan ÖZGÜR, Önder ALBAYRAK, Mahmut DAĞLI

Nutritional composition of Spiny eel (Mastacembelus mastacembelus) caught from the Atatürk Dam Lake in Turkey

Oğuz TAŞBOZAN, Mahmut Ali GÖKÇE, Mehmet ÇELİK, Şefik Surhan TABAKOĞLU, Aygül KÜÇÜKGÜLMEZ, Asiye BAŞUSTA

Investigation on Toxoplasma gondii in Surface and Drinking Water Samples from Amasya by Nested Polymerase Chain Reaction

Zeynep KOLOREN, Elif DEMİREL

Faunistic notes on the cybaeid spiders of Turkey (Araneae: Cybaeidae)

Recep Sulhi ÖZKÜTÜK, Mert ELVERİCİ, Kadir Boğaç KUNT, Ersen Aydın YAĞMUR

Removal of cadmium (II) ion from aqueous system by dry biomass, live and heat- inactivated Scenedesmus quadricauda isolated from fresh water (Apa Dam Lake)

Cengiz AKKÖZ, Betül YILMAZ ÖZTÜRK, Baran AŞIKKUTLU

Characterization of an Oxidant and Detergent Stable Alkaline Protease Produced from a Novel Isolate Bacillus sp. Strain

Zeliha Nurdan SARAÇOĞLU, Deniz TANRISEVER, Burhan ARIKAN, Hatice KORKMAZ GÜVENMEZ

Effect of Herbicides on Chlorophyll-a, β- Caroten, Phycocyanin and Allophycocyanin Content of Anabaena sp

G. OKMEN, O. TURKCAN, P. ERDAL