Sinem Nur SELÇUK, Murat YURDAKÖK, Şule YİĞİT

Preeklamptik Anne Bebeklerinde Ortalama Platelet Hacmi (MPV) ve Neonatal Sonuçlar

Amaç Preeklampsi hem maternal hem de neonatal komplikasyonlara yol açabilen bir hastalıktır. Hastalığın fetal ve neonatal komplikasyonlarına uteroplasental yetersizliğin yol açtığı düşünülmektedir. Güncel bilgiler doğrultusunda hastalığın etyolojisi ve patogenezinde inflamasyonun da maternal bulgulardan sorumlu olduğu görülmüş ve neonatal bulguların da inflamasyonla ilişkili olabileceği düşünülmüştür. Bu amaçla, preeklampsi olan gebelerde yüksek olduğu görülen MPV’nin (mean platelet volume) preeklamptik anne bebeklerinde de değerlendirilmesi planlanmıştır. Materyal ve metod Bu çalışma, Hacettepe Üniversitesi Ihsan Doğramacı Çocuk Hastanesi Yenidoğan Yoğunbakım Ünitesi’ne yatışı yapılmış olan 148 preeklamptik anne bebeği ve kontrol grubu için tabakalı örnekleme sistemi ile seçilmiş 147 bebeğin değerlendirmeleri ile yapılmıştır. Gruplar arasında hematolojik parametreler (MPV, hemoglobin değerleri, beyaz küre trombosit sayısı) ve sık görülen neonatal morbiditeler (SGA (gebelik haftasına göre düşük ağırlık), respiratuar distres sendromu, nekrotizan enterokolit, intraventriküler kanama, PDA (patent ductus arteriosus)) karşılaştırılmıştır. Bulgular Preeklamptik annelerin bebeklerinde MPV ve hemoglobin değerleri anlamlı olarak (p

Anahtar Kelimeler:

preeklampsi, inflamasyon, sFLT-1, sVEGFR-1, soluble endoglin

Mean platelet volume (MPV) and neonatal outcomes of infants born to mothers with preeclampsia

Aim Preeclampsia may cause both maternal and neonatal complications. Uteroplacental dysfunction is one of the reasons of fetal and neonatal complications in preeclampsia. Recent findings about the etiology and pathogenesis of the disease shows that inflammation is one of the factors responsible for maternal complications, thus neonatal complications should be associated with the same inflammatory process. We considered evaluating mean platelet volume (MPV) of infants born to mothers with preeclampsia, based on the findings of elevated MPV values in pregnant women with preeclampsia. Materials and methods This study was carried out at the Neonatal Intensive Care Unit of Hacettepe University Ihsan Dogramacı Children’s Hospital and consisted of 148 infants born to mothers with preeclampsia and 147 infants as a control group which were selected by stratified sampling system. Hematological parameters (mean platelet volume, hemoglobin values, white blood cell and platelet counts) and common neonatal morbidities (small for gestational age, respiratory distress syndrome, necrotizing enterocolitis, intraventricular hemorrhage and patent ductus arteriosus) were evaluated between groups. Results The infants of mothers with preeclampsia had significantly elevated MPV and hemoglobin values (p

Keywords:

preeclampsia, inflammation, sFLT-1, sVEGFR-1, soluble endoglin,

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