Polikistik Over Sendromunda Renin Anjiotensin Aldosteron Sisteminin Plazma Renin Aktivitesi ile Değerlendirilmesi

Amaç: Polikistik over sendromu PKOS ile renin anjiotensin aldosteron RAS sisteminin ilişkisini araştırmaktır.Gereç ve Yöntemler: Çalışma Kırıkkale Üniversitesi Tıp Fakültesi Jinekoloji polikliniğine başvuran, 18-40 yaş arası, 96 PKOS tanısı alan hasta ile, 30 PKOS olmayan sağlıklı kontrol hastası toplam 126 hastanın dahil edildiği, prospektif kesitsel bir çalışmadır. Tüm hastalara sabah aç ve ayakta alınan kan örneklerinde plazma renin aktivitesi PRA çalışıldı. Gruplar arasında PRA açısından istatistiksel anlamlı bir farkın olup olmadığı değerlendirildi.Sonuç: PKOS tanısı alan hasta grubunda PRA 287 10-693 pg/ml, kontrol grubunda PRA 213 50-802 pg/ml tespit edildi. Sonuçta PKOS da PRA düzeylerinde anlamlı bir artış saptanmaktadır p=0,048 Bu artış PKOS da RAS sisteminde bir aktivasyona işaret etmektedir.

Anahtar Kelimeler:

Polikistik over sendromu, plazma renin aktivitesi, renin anjiotensin aldosteron sistemi

Evaluation Of Renin Angiotensin Aldosteron System With Plasma Renin Activity In Polycystic Ovarian Syndrome

Aim: The present study intends to investigate the relationship between polycystic ovarian syndrome PCOS and renin anjiotensin aldosteron system RAS .Material and Methods: It is a prospective cross-sectional study conducted at Gynecology Clinic of Faculty of Medicine in Kirikkale University. The study group consists of a total of 126 patients, aged between 18 and 40. 96 were diagnosed with PCOS, and 30 were non-PCOS patients control group . All the patients were given a fasting blood test in the morning, and the plasma renin activity PRA was assessed. Statistical analyses were performed to see the difference between the groups.Conclusion: PRA was 287 10-693 pg/ml and 213 50-802 pg/ml in PCOS and non-PCOS group, respectively. Statistically significant difference was identified between the groups p:0.048 . In brief, PRA levels increase significantly in PCOS, which indicates an activity in the RAS in PCOS.

Keywords:

Plasma renin activity, polycystic ovarian syndrome, renin angiotensin aldosterone system,

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