Yunus YILDIZ, Gülnur ÖZAKŞİT, Elif Gül Yapar EYİ, Emre ÖZGÜ, Bekir Serdar ÜNLÜ, Hasan ENERGİN

POLİKİSTİK OVER HASTALARINDA İNSULİN DİRENCİ, METABOLİK DURUM VE METABOLİK PARAMETRELER ARASINDAKİ İLİŞKİ

Amaç: Polikistik over sendromu PCOS tanısı konulmuş bireylerde klinik, metabolik ve hormonal parametreler, insülin direnci araştırması ve birbiri ile ilişkilerini incelemekti. Yöntem ve Gereçler: Ağustos 2010 - ağustos 2011 tarihleri arasında Zekai Tahir Burak Kadın Sağlığı ve Hastalıkları Hastanesi İnfertilite ve Gençlik Merkezi Poliklinikleri’ne adet düzensizliği, tüylenmede artış, obezite şikâyetleri ile başvuran toplam 81 hastada da yapıldı. Tüm hastalarda serum açlık insülin ve glukoz, 75 gr. oral glukoz tolerans test OGTT , düşük dansiteli li- poprotein LDL , trigliserid TG , yüksek dansiteli lipoprotein HDL , 17 hidroksiprogesteron, dehidroepiandrostenedion, androstenedion, total ve serbest testos- teron, tiroid stimulan hormon TSH seviyeleri araştırıldı. Vücut kitle indeksi VKI ve Homeostasis Model Assessment of İnsulin Resistance HOMA-IR skorları hesaplandı. Bulgular: VKI değerlendirmesinde VKI>25 n=32 %39,5 olan hastalarda HOMA-lR skoru, açlık insülin seviyesi ve 2.saat 75 gr OGTT değeri, VKI25 olan gruba göre anlamlı derecede yüksekdi p

Anahtar Kelimeler:

Polikistik over sendrom PCOS, insülin direnci, vücut kitle indeksi

INSULIN RESISTANCE, METABOLIC STATUS AND RELATION BETWEEN METABOLIC PARAMETERS IN POLYCYSTIC OVARY SYNDROME PATIENTS

Aim: to investigate the hormonal status, insulin resistance, clinical and metabolic parameters and their correlation in polycystic ovary syndrome PCOS patients. Material And Methods: The study was performed on a total of 81 patients with menstrual irregularity, hirsutism and obesity who were admitted to Zekai Tahir Burak Women’s Health Educational and Research Hospital infertility and adolescent outpatient clinics between August 2010- August 2011. The serum levels of fasting insulin and glucose, 75 g oral glucose tolerance test OGTT , low density lipoproteins LDL , triglyseride TG , high density lipoproteins HDL , 17-hydroxyprogesterone, dehydroepiandrostenedione, androstenedione, total and free testosterone, thyroid stimulan hormon TSH were investigated, and body mass index BMI , homeostasis model assessment of insulin resistance HOMA-IR scores were calculated for all participants. Results: On Body Mass Index BMI match tests; serum levels of fasting glucose, fasting insulin and 2. hour 75 gr OGTT results were significantly higher in patients with BMI>25 n=32 %39,5 p25 n=49 %60,5 serum levels of triglyseride were significantly higher than patients with BMI

Keywords:

Polycystic over Syndrome, insulin resistance, body mass index,

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