Tayfun GÜNGÖR, İlker SELÇUK, Şule ÖZEL, Yaprak ENGİN ÜSTÜN

Over Kanseri Perspektifinde BRCA Gen Mutasyonları Ve Herediter Meme ve Over Kanser Sendromu

Over kanseri en çok ölümle sonuçlanan jinekolojik kanser olup, tarama çalışmalarıyla beraber önleyici girişimler ile ölüm oranlarının azaltılması için çok fazla çalışma vardır. Hastalık çoğunlukla sporadik gelişse de, ailesel faktörler ve genetik kökenli yatkınlık bazı bireyleri toplumsal oranlara göre artmış bir risk kuşağına sokmaktadır. Ailesel over kanseri yatkınlığı olan kişilerde en sık BRCA gen mutasyonları tespit edilmiş olup, BRCA gen mutasyonu taşıyan kişilere verilecek olan hizmetler; genetik danışmanlık, tarama ve koruyucu girişimler belli bir perspektif içerisinde tecrübeli bir ekip tarafından multi-disipliner bir yapıda yapılmalıdır.

Anahtar Kelimeler:

BRCA, over kanseri, tarama, takip

BRCA Gene Mutations And Hereditary Breast And Ovarian Cancer Syndrome From The Perspective Of Ovarian Cancer

Since ovarian cancer has the highest mortality rates among all the gynecological cancers, there is a tremendous effort to decrease this occasion by surveillance and prophylactic interventions. Ovarian cancer is mostly sporadic, however some people have an increased risk than the overall population due to hereditary and genetic predispositions. BRCA gene mutations are most commonly detected pathology in whom have a hereditary ovarian cancer risk. Genetic counseling, surveillance and prophylactic surgeries with regard to BRCA gene mutations should be applied by an experienced team in a multi-disciplinary approach.

Keywords:

BRCA, ovarian cancer, screening, follow-up,

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