Seyhun SUCU, Hüseyin Çağlayan ÖZCAN, Neslihan BAYRAMOĞLU TEPE, Hilmi TAŞDEMİR, Özcan BALAT, Özge KÖMÜRCÜ KARUSERCİ, Mete Gürol UĞUR, Tanyeli GÜNEYLİGİL KAZAZ

Low Serum Vitamin D and Normal Serum 8-Hydroxy-2-Deoxyguanosine Levels in Endometrioma Patients: Is It a Dilemma?

Amaç: Endometrioma hastalarında serum 25-OH vitamin D ve 8-Hidroksi 2-deoksigunazin (8-OH2dG) seviyelerini karşılaştırmak, kist boyutu ile ilişkisini saptamak. Gereç ve Yöntemler: Çalışmaya endometrioma tanısı alan 54 hasta ile normal over dokusuna sahip 26 hasta kontrol grubu olarak dahil edildi. Serum örneklerinde 25-OH vitamin D ve 8-OH2dG seviyelerine bakıldı. Bulgular: Hasta ve kontrol grubu arasında yaş, gebelik, doğum sayısı ve vücut kitle indexi (VKI) bakımından farklılık yoktu. Hasta grubunun D vitamini düzeyi, kontrol grubuna göre anlamlı derecede düşüktü (p=0.001). Kisti bilateral olan hastalar ile, kisti unilateral olan hastalar arasında D vitamini düzeyleri bakımından anlamlı farklılık yoktu (p=0.39). Hasta grubunda 48 (%88.8), kontrol grubunda 11 (%42.3) hastada D vitamini seviyesi <30-microgr/L idi. Hasta grubunda, D vitamini düzeyi hipovitaminoz seviyede olan hastalarda ortalama endometrioma çapı 58,4±25,14 mm iken, D vitamini düzeyi normal saptanan hastalarda endometrioma çapı ise 35,33±18,26 mm idi. Hipovitaminoz D saptanan hastalarda kist çapı ile D vitamini düzeyleri arasında ters bir ilişki saptandı. İki grup arasında 8-OH2dG düzeyleri bakımından anlamlı farklılık yoktu (p>0.05). Sonuç: Endometrioma varlığı, kist çapı ve serum D vitamini düzeyleri arasında ters ilişki olmasına rağmen, serum 8-OH2dG düzeylerinde değişiklik yoktu. Bu durum, overyan endometriozisin patogenezinde hala belirsiz noktalar olduğunu göstermektedir.

Anahtar Kelimeler:

Endometrioma, 25-OH vitamin D

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