In Vitro Fertilizasyon Uygulanacak Polikistik Over Sendromlu Hastalar İçin Myo-İnositol Ve Folik Asit Desteği

Amaç: Myo-inositol’un IVF hastalarında serum düzeylerinden bağımsız olarak ovaryan fonksiyon ve oosit kalitesini artırdığı izlenmiştir. Biz de bu PCOS’lu IVF hastalarında myo-inositol’un hormonal ve klinik parametreler üzerine etkisini araştırmayı hedefledik.Gereç ve Yöntemler: Ocak 2013 ve Mayıs 2015 arasında üniversitemiz üreme sağlığına IVF/ICSI için başvurmuş hastalar retrospektif olarak değerlendirildi.Tüm hastalar ikinci IVF siklusundan önce en az 12 hafta myo-inozitol ve folik asid replasmanını 1gr/gün aldı ve çalışma sonucunda klinik gebelik oranları, implantasyon oranı, toplanan oosit sayısı, metafaz 2 oosit sayısı, grade A embriyo sayısı ve siklus iptal oranları değerlendirildi.Bulgular: Çalışma sonucunda MI-FA replasmanı sonrası gebelik oranları artmış olsa da istatiksel olarak anlamlı bulunmamıştır. Benzer şekilde M2 oosit sayısında azalma 14 ve 17 mm’lik folikül sayısı ve transfer edilen embriyo sayısında artış, siklus iptal oranlarında azalma izlense de istatiksel olarak anlamlı bulunmamıştır.Sonuç: Çalışmamızda ele alınan hasta sayısı az olmakla birlikte, bazı parametrelerde tedavi öncesine göre düzelme izlenmiş ancak istatiksel anlamlılık bulunmamıştır.

Anahtar Kelimeler:

İn vitro fertilizasyon, polikistik over sendromu, myo-inositol, folik asid, gebelik oranı

Myo-Inositol And Folic Acid Supplementation For The Policystic Ovary Syndrome Patients Undergoing In-Vitro Fertilization Cycles

Aim: We evaluated the effects the administration of “Myo-inositol plus Folic acid” MI-FA supplementation on ovarian reserve markers and in-vitro fertilization IVF cycle in patients with polycystic ovary syndrome PCOS patients.Material and Methods: Totally 58 PCOS women aged

Keywords:

In-vitro fertilization, polycystic ovary syndrome, myo-inositol, folic acid, pregnancy rates,

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