Effects of the menstrual cycle on rocuronium injection-related withdrawal movement

Objective: Pain and withdrawal movement after rocuronium injection are very frequently seen in clinical practice. In this prospective, double-blind study, we aimed to evaluate the effect of menstrual cycle on withdrawal movement due to rocuronium injection. Methods: A total of one-hundred patients who will undergo elective surgery under general anesthesia were distributed evenly into Groups F (Follicular phase) and L (Luteal phase). Rocuronium-induced witdrawal movement was evaluated using a 4-point scale. This study is registered in the website (clinicaltrial.gov.) Results: The rocuronium injection-related withdrawal movement (RIWM) score of the follicular Group 0 (0-1) was significantly lower than the score of the luteal Group 1 (0-1.25) (p=0.001). Rocuronium- induced withdrawal movement score of the luteal group was higher than that of the follicular group. And also, there was an increase in hemodynamic parameters in the luteal group after rocuronium injection. Conclusion: We determined that the rate of rocuronium injection-related withdrawal movement was higher in the luteal phase compared to the follicular phase. We also determined that the levels of the hemodynamic parameters were higher during the operation in patients in the luteal phase in whom the rate of withdrawal movement increased.

Rokuronyum ilişkili geri çekme hareketi üzerine menstrual siklusun etkileri

Amaç: Rokuronyum enjeksiyonu sonrası ağrı ve geri çekme hareketleri, klinikte oldukça sık görülmektedir. Bu prospektif, çift kör çalışmada, menstruel siklusun rokuronyum enjeksiyon ağrısına etkisini değerlendirmeyi amaçladık. Yöntem: Genel anestezi altında elektif cerrahi yapılacak 100 hasta çalışmaya alındı. Menstrual siklus fazlarına göre 50 hasta, Group F (Folikuler faz) ve 50 hasta group L (Luteal faz) olarak ikiye ayrıldı. Rokuronyum ilişkili geri çekme hareketi 4-nokta skalası ile değerlendirildi. Bu çalışma clinicaltrial.gov adresinde kayıtlıdır. Bulgular: Folikuler grubun geri çekme skoru median 0 (0-1) luteal gruptan 1 (0-1,25) anlamlı düşük saptandı (p=0,001). Rokuronyum ilişkili geri çekme hareketi skorunun, luteal grupta folikuler gruptan yüksek olduğu saptandı. Ayrıca rokuronyum enjeksiyonu sonrası luteal grupta hemodinamik parametrelerde de artış saptadık. Sonuç: Rokuronyum ilişkili geri çekme hareketinin luteal fazda folikuler faza kıyasla daha fazla oluştuğunu saptadık. Ayrıca operasyon sırasında çekilme hareketinin arttığı luteal fazdaki hastalarda, hemodinamik parametrelerde de yükselme olduğunu saptadık.

Kaynakça

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Kaynak Göster

İzmir Tepecik Eğitim Hastanesi Dergisi
  • ISSN: 1305-7073
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 1991

11.6b6.1b

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