Clinical Trials during Late Pregnancy in Mares: Prevention of Abortion

Çalışmada kısraklardaki düşüklerin yüksek-dönüşüm hızlı vitaminlerin, amino asitlerin ve minerallerin yerine geçmesi amacıyla bir tamamlayıcı olan Haemobalans® ve Bifidobacterium bifidum içeren probiotik BF-15 ile entegre tedavisinin etkisi araştırılmıştır. Çalışmada, geç gebelik döneminde uygulanan Haemobalans ve BF-15 gibi adoptojenlerin etkilerinin ispat edilmesi amaçlandı. Çalışmada, gebeliğin 270 - 300. günlerinde dört eşit gruba (n=15) ayrılan 60 sağlıklı erişkin İngiliz kısrak araştırıldı. Kullanılan kısraklara 3 gün içinde, her 45 kg vücut ağırlığına 1 ml dozda olacak şekilde Haemobalans® intramüsküler yolla uygulandı. BF-15 de 10 gün süreyle günde 2 kez yulaflı 20 ml oral solüsyon olarak verildi. Reflex-1 grubu aynı doz Haemobalans ile tedavi edildi. Reflex-2 grubu aynı doz BF-15 ile tedavi edildi. Kontrol hayvanları da incelemeye alındı. Tedaviden önce ve tedaviden iki hafta sonra kan örnekleri alındı. İlk inceleme araştırılan kan değerlerinin temel düzeylerini gösterdi, son inceleme ise tedavinin sonucunu gösterdi. Her grupta veriler arasındaki fark (tedaviden önce ve sonra elde edilen) karşılaştırıldı. Test grubundaki verilerin diğer üç gruba oranla anlamlı farklı olduğu durumda, sonuçların güvenirliği tartışıldı. Doğumdan sonra plasenta dokusu alındı, nötral formalin ile sabitlendi ve hematoksilin ve eosin ile boyandı. Patolojik değişim alanları belirlendi. Plasenta çalışmasında kategoriksel bilgilerin veritabanı oluşturuldu. Plasental yetersizlik (PI) belirteçleri için vaka sayıları belirlendi. Bir hayvanın kişisel veritabanında patolojik vaka mevcudiyeti (1), eksikliği ise (0) olarak belirtildi. (1)'in objektif olarak fazlası PI olarak kabul edildi. Test grubunda glukoz, total protein, kreatinin, hemoglobin, B12 vitamini, ESR, lenfosit sayısı ve MCHC anlamlı olarak daha yüksek bulundu: tespit edilen değerler sırasıyla %16,4, %10,78, %17,8, %11,7, %9,5, %14,7, %22,2, %10,5 (P

Kısraklarda Son Gebelik Dönemindeki Klinik Çalışmalar: Yavru Atmaların Önlenmesi

The paper observed the influence of the integrated treatment of abortion in mares with the supplement Haemobalans® to replace high-turnover vitamins, amino acids and minerals; and probiotics BF-15®which contains Bifidobacterium bifidum. The aims of this study were to prove the application of Haemobalans and BF-15 as adaptogens during late gestation. We examined 60 healthy adult Thoroughbred mares that were divided into four equal groups (n=15) on the 270 - 300th days of gestation. Test animals received the following treatment: 1 intramuscular injection of Haemobalans in 3 days, in a dose of 1 ml per 45 kg of body weight. BF-15 was also given for 10 days: 20 ml of the oral solution with oats two times per day. Reflex-1 group was treated with the same dose of Haemobalans. Reflex-2 group was treated with the same dose of BF-15. Control animals were also examined. Blood samples were taken before the treatment and two weeks after it. First examination showed the basic level of investigated sources, the last one showed the result of the treatment. The difference between the data (which were obtained before and after treatment) was compared in each group. In case of significant differences between the data of the test group relative to the other three groups, we talked about the reliability of the outcomes. Tissue of placentae were taken after delivery, fixed with neutral formalin and stained with hematoxylin and eosin. Zones of pathological changes were identified. Database of categorical data was created in placental study. Number of cases for markers of placental insufficiency (PI) was determined. In the personal database of one animal the presence of a pathological case was marked (1) and the absence was marked (0). The objective excess of (1) was regarded as PI. The concentrations of glucose, total protein, creatinine, hemoglobin, vitamin B12, ESR, count of lymphocyte and MCHC in the test group were significantly higher: 16.4%; 10.78%; 17.87%; 11.7%; 9.5%; 14.7%; 22.2%, 10.5% higher respectively (P

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