Geranium Uçucu Yağı ve Siprofloksasin ile Kombinasyonlarının Stapyhlococcus Aureus ve Esherichia Coli'ye Karşı Sinerjik Potansiyeli
Amaç: Pelargonium graveolens bitkisinden elde edilen Geranium uçucu yağının, enfeksiyonların tedavisinde kullanılan kinolon grubu antibiyotiklerden biri olan siprofloksasin ile kombine edilerek, sık rastlanan hastane enfeksiyonu etkeni patojen mikroorganizmalara karşı antimikrobiyal etkilerinin in vitro deney modelinde gösterilmesi çalışmamızın temel amacını oluşturmaktadır.
Synergic Potential of Geranium Essential Oil and Ciprofloxacin Combination Against on Staphylococcus Aureus and Escherichia Coli
Aim: The main purpose of our study is that Geranium essential oil obtained from Pelargonium graveolens plant is combined with ciprofloxacin, a quinolone antibiotic used in the treatment of infections, to reveal its antimicrobial effects against pathogenic microorganisms, which are common nosocomial infections, in an in vitro experimental model.
___
- Kanra G, Ceyhan M, Kara A. Menenjit III: Tedavi. Çocuk Sağlığı ve Hastalıkları Dergisi. 2003;46:217-223.
- Ayaz C. Antibiyotik Kombinasyonları, Klimik Dergisi. 2001;14(3):140-143.
- Pereira V, Dias C, Vasconcelos MC, Rosa E, Saavedraa MJ. Antibacterial activity and synergistic effects between Eucalyptus globulus leaf residues (essential oils and extracts) and antibiotics against several isolates of respiratory tractinfections (Pseudomonas aeruginosa), Industrial Crops and Products. 2014;52:1-7.
- Yap PSX, Lim SHE, Hu CP, Yiap BC. Combination of essential oils and antibiotics reduce antibiotic resistance in plasmid-conferred multidrug resistant bacteria, Phytomedicine. 2013:20;710-713.
- Dumlupinar B, et al. Synergic potential of Pelargonium endlicherianum Fenzl. Essential oil and antibiotic combinations against Klebsiella pneumoniae. South African Journal of Botany. 2020:135;117-126.
- Dumlupinar B, et al. Synergy between Pelargonium endlicherianum essential oil and conventional antibiotics against Neisseria meningitidis and Haemophilus influenzae. South African Journal of Botany. 2022:146;243-253.
- Yap PSX, Krishnan T, Chan KG, Lim SHE. Antibacterial mode of action of cinnamomum verum bark essential oil, alone and in combination with piperacillin, against a multi- drug-resistant escherichia coli strain, J. Microbiol. Biotechnol. 2015;25(8):1299–1306.
- Davis PH, Hedge IC. Pelargonium L’Hérit In: Flora of Turkey and the East Aegean Islands. Edinburgh: University Press; 1967:2;487-9.
- Ceyhan M, Yildirim I, Balmer P, et al. A prospective study of etiology of childhood acute bacterial meningitis. Emerging Infectious Disease, 2008;14(7):089-1096.
- Techasaensiri C, Messina AF, Katz K, Ahmad N, Huang R, McCracken GH Jr. Epidemiology and evolution of invasive pneumococcal disease caused by multidrug resistant serotypes of 19A in the 8 years after implementation of pneumococcal conjugate vaccine immunization in Dallas, Texas. Pediatric Infectious Disease Journal. 2010;29(4):294-300.
- Özsürekci Y. Türkiye’de Menenjite Neden Olan Bakteriyel Ajanlar ve Meningokokal Serogrupların Seroprevalansı. [yan dal uzmanlık tezi]. Ankara: Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Hacettepe Üniversitesi, Tıp Fakültesi; 2013.
- Lis-Balchin M. Geranium oil. International Journal of Aromatherapy. 1996;7:18-20
- Lis-Balchin M. Geranium and Pelargonium. UK, London: Taylor & Franchis Group; 2002;116:1-3.
- Abouelatta AM, Keratum AY, Ahmed SI. et al. Repellent, contact and fumigant activities of geranium (Pelargonium graveolens L.’Hér) essential oils against Tribolium castaneum (Herbst) and Rhyzopertha dominica (F.). Int J Trop Insect Sci. 2020:40;1021–1030 https://doi.org/10.1007/s42690-020-00161-4.
- Verma Ram S, et al. Chemical composition and antimicrobial activity of Java citronella (Cymbopogon winterianus Jowitt ex Bor) essential oil extracted by different methods. Journal of Essential Oil Research. 2020:449-455.
- Lira, Maria Helena Pereira de, et al. Antimicrobial activity of geraniol: An integrative review. Journal of Essential Oil Research. 2020:187-197.
- Borges A, Ferreira C, Saavedra MJ, Simoes M. Antibacterial activity and mode of action of ferulic and gallic acids against pathogenic bacteria. Microbial Drug Resistance. 2013:19;256-265.
- Vaara M. Agents that increase the permeability of the outer membrane. Microbiology Reviews. 1992:56;395-411.
- Luqman S, Dwivedi GR, Darokar MP, Kalra A, Khanuja SP. Potential of rosemary oil to be used in drug-resistant infections. Altern Ther Health Med. 2007;13(5):54-9.
- Su JY, Zhu L, Tian YJ. Chemical composition and antimicrobial activities of essential oil of Matricaria songarica. International Journal of Agricultural Biology. 2012;14(1):107-10.
- Hemaiswarya S, Doble M. Synergistic interaction of eugenol with antibiotics against Gram negative bacteria. Phytomedicine. 2009;16(11):997-1005. https://doi.org/10.1016/j.phymed.2009.04.006.
- Gibbons S, Oluwatuyi M, Veitch NC, Gray AI. Bacterial resistance modifying agents from Lycopus europaeus. Phytochemistry. 2003;62(1):83-7.