B. PALECZ, A. BUCZKOWSKI, L. B. ZAVODNIK

Chemistry of Secondary Metabolites (Production, Properties, Biological Activity, etc.): Solubility Study of the Interaction between Pamam G-3 Dendrimer and 5 Fluorouracil in Aqueous Solution

Yayın Aralığı: 4
Başlangıç: 2014
Yayıncı: İzzet KARA

Poly(amidoamine) dendrimers (PAMAM) are polymeric macromolecules that can find their use as carriers of small ligand molecules such as cosmetics and drugs. 5- Fluorouracil is a potent oncological drug, whose usage is limited because of its relatively high toxicity.The surface and internal layer groups in PAMAM dendrimer belonging to the third (G3) generation create an open-type structure, which facilitate small ligand molecules to bind with them.The formation equilibrium of PAMAM G3 dendrimer complex with an oncologic drug such as 5 fluorouracil (FU) in water at room temperature was examined. Using the results of the drug solubility in dendrimer solutions, the maximal number of drug molecules in the dendrimer-drug complex was evaluated. Solubility results show that PAMAM G3 dendrimer can transfer tens 5 fluorouracil molecules in aqueous solution.This research work was funded from the Polish budget appropriations for science in the years 2013-2015, project number IP2012 022372.

Keywords:

poly(amidoamine) dendrimers, 5 fluorouracil, Metabolites,

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University of Lodz, Poland, 90-236, Lodz, Pomorska St., 165, Department of Physical Chemistry
Grodno State Agricultural University, Belarus, 230023, Grodno, Volkovich St., 1, Department of Pharmacology and Physiology