Trombocytopenia related to colchicine: report of two cases
Trombocytopenia related to colchicine: report of two cases
Familial Mediterranean fever (FMF) is the most frequent autoinflammatory disease which can be well controlled with lifelong use of colchicine. Daily colchicine use has been shown to reduce the frequency, severity, and duration of attacks. Colchicine also has been found to be effective in decreasing the prevalence of amyloidosis. Therapeutic oral dose of colchicine (0.5-2.0 mg/ day) may cause cramping, abdominal pain, hyperperistalsis, diarrhea and vomiting. Besides, colchicine may rarely cause bone marrow failure, agranulocytosis and/ or thrombocytopenia as well. Here in we report two pediatric cases of FMF who developed trombocytopenia after colchicine medication and call attention to colchicine related trombocytopenia.
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- Gaygusuz ET, Kuzucuoğlu T, Yücel E, Karaman T, Yılmaz H. J Kartal TR. Yoğun bakım ünitesinde pediatrik kolşisin zehirlenmesi: olgu sunumu 2009;XX(3):151-3.
- Todd BA, Billups SJ, Delate T, Canty KE, Kauffman AB, Rawlings JE. Et al. Wagner TM. Assessment of the association between colchicine therapy and serious adverse events. Pharmacotherapy 2012;32(11):974-80.
- Bonnel RA, Villalba ML, Karwoski CB, Beitz J. Deaths associated with inappropriate intravenous colchicine administration. J Emerg Med 2002;22(4):385-7.
- Levy M, Spino M, Read SE. Colchicine: a state-of-the-art review. Pharmacotherapy 1991;11(3):196-211.
- Ozdemir R, Bayrakci B, Teksam O. Fatal poisoning in children: acute colchicine intoxication and new treatment approaches. Clin Toxicol (Phila) 2011;49(8):739-43.
- Zemer D, Livneh A, Danon YL, Pras M, Sohar E. Long term colchicine treatment in children with familial Mediterarnean fever. Arthritis Rheum 1991;34(8):973-7.
- Leung YY, Yao Hui LL, Kraus VB. Colchicine: Update on mechanisms of action and therapeutic uses. Semin Arthritis Rheum 2015;45(3):341-50.
- Bonnotte B, Gresset AC, Chvetzoff G, Martin F, Lorcerie B, Chauffert B. Efficacy of colchicine alone or in combination with vinca alkaloids in severe corticoidresistant thrombocytopenic purpura: six cases. Am J Med 1999;107(6):645-6.
- Ahmed FE, Albakrah MS. Neonatal familial Evans syndrome associated with joint hypermobility and mitral valve regurgitation in three siblings in a Saudi Arab family. Ann Saudi Med 2009;29(3):227-30.
- Cocco G, Chu DC, Pandolfi S. Colchicine in clinical medicine. A guide for internists. Eur J Intern Med 2010;21(6):503-8.
- Ben-Chetrit E, Levy M. Colchicine: 1998 update. Semin Arthritis Rheum 1998;28(1):48-59.
- Gedalia A, Adar A, Gorodischer R. Familial Mediterranean fever in children. J Rheumatol Suppl 1992;35:1-9.
- Polat A, Acikel C, Sozeri B, Dursun I, Kasapcopur O, Gulez N, et al. FMF Arthritis Vasculitis and Orphan Disease Research in Pediatric Rheumatology (FAVOR). Comparison of the efficacy of once- and twice-daily colchicine dosage in pediatric patients with familial Mediterranean fever--a randomized controlled noninferiority trial. Arthritis Res Ther 2016;7;18:85.