Histopathological findings in women that living Elazig with abnormal uterine bleeding: in 20 years

Aim: Abnormal uterine bleeding refers to any uterine bleeding that occurs in excessive amounts of regular menstrual bleeding or any postmenopausal bleeding. The present study aims to determine histopathological findings in Turkish women with abnormal uterine bleeding in Elazığ.Material and Methods: Retrospectively 420 women with abnormal uterine bleeding were included in the study. Hematoxylin and eosin sections of the cases were re-evaluated by a single pathologist.Results: Of the 316 premenouposal cases %37,02 was diagnosed as (n=117) proliferative endometrium, %22,46 as (n=71) secretuar endometrium, as %3,79 (n=12) desidualisation, as %1,26 (n=4) atrophy, as %2,53 (n=8) placental tissue, as %12 (n=38) dysfunctional uterine bleeding, %12,34 (n=39) as endometrial polyp, %7,9 (n=25) as endometrial hyperplasia, and %0,63 (n=2) as endometrial adenocarcinoma. Of the 104 postmenouposal cases diagnosed as %10,57 (n=11) proliferative endometrium, %0,96 as (n=1) secretuar endometrium, %17,30 (n=18) as desidualisation, %13,46 (n=14) as endometrial polyp, %39,42 (n=41) atrophy, %12,5 (n=13) as endometrial hyperplasia, %5,76 (n=6) as endometrial adenocarcinoma.Conclusions: In our region, because endometrial sampling results belong patients with abnormal uterine bleeding which is usually concordant to age and menstrual cycle, We conclude that non-invasive methods should be tried before sampling. Endometrial carcinoma risk is consistent with the literature,so endometrial samplings should not be avoided?

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Bitiren M, Özardalı M, Baba F, Nazlıgül Y, Eraslan H. The evaluation of cancer data in Şanlıurfa Province (1995–2002). Türkiye Ekopatoloji Dergisi 2003;9(1-2):11-6.
Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C, et al. Cancer statistics, 2006. CA Cancer J Clin 2006;56(2):106-30.
Bunkheila AK, Powel MC. Menorrhagia and dysfunctional uterine bleeding. Current Obstetrics & Gynaecology 2002;12:328-333.
Tuncer R, Uygur R, Kış S. Ankara Zübeyde Hanım Doğumevi 2000 yılı Endometrial Biyopsi Sonuçları: 676 Olgunun Analizi. 2003;9:97-9.
Kucur SK, Şencan H, Yüksel KB, Gözükara İ, Seven A, Keskin N, et al. Endometrial Örnekleme Sonuçlarımız: 744 Olgunun Analizi. Zeynep Kamil Tıp Bülteni 2014;45:146-50.
Allison KH, Reed SD, Voigt LF, Jordan CD, Newton KM, Garcia RL. Diagnosis endometrial hyperplasia: why is it so difficult to agree? Am J Surg Pathol 2008;32(5):691-8.
Ricci E, Moroni S, Parazzini F, Surace M, Benzi G, Salerio B. et al. Risk factors for endometrial hyperplasia: results from a case-control study. Int J Gynecol Cancer 2002;12(3):257-60.
Reed SD, Newton KM, Clinton WL, Epplein M, Garcia R, Allison K, et al. Incidence of endometrial hyperplasia. Am J Obstet Gynecol 2009;200(6):678.e1-6.
Baak JPA, Orbo A, van Diest PJ, Jiwa M, de Bruin P, Broeckaert M, et al. Prospective multicenter evaluation of the morphometric D-score for prediction of the outcome of endometrial hyperplasias. Am J Surg Pathol 2001;25(7):930-35.
Pereira N, Petrini AC, Lekovich JP, Elias RT, Spandorfer SD. Surgical management of endometrial polyps in ınfertile women: a comprehensive review. Surg Res Pract 2015;2015:914390.
Lieng M, IstreO, Qvigstad E. Treatment of endometrial polyps: a systematic review. Acta Obstet Gynecol Scand 2010;89(8):992-1002.
Indraccolo U, Di Iorio R, Matteo M, Corona G, Greco P, Indraccolo SR. The pathogenesis of endometrial polyps: A systematic semi-quantitative review. Eur J Gynaecol Oncol 2013;34(1):5-22.
Elfayomy AK, Soliman BS. Risk Factors Associated with the Malignant Changes of Symptomatic and Asymptomatic Endometrial Polyps in Premenopausal Women. J Obstet Gynaecol India 2015;65(3):186-92.
Turnbull H, Glover A, Morris EP, Duncan TJ, Nieto JJ, Burbos N. Investigation and management of abnormal perimenopausal bleeding. Menopause Int 2013;19(4):147-54.
Mazur MT, Kurman RJ. Diagnosis of endometrial biopsies and curettings. Second ed. USA: Springer; 2005.pp:178-207.
Stovall TG, Ling FW, Morgan PL. A prospective, randomized comparison of the pipelle endometrial sampling device with the Novak curette. Am J Obstet Gynecol 1991;165(5 Pt 1):1287-90.
Fox KE. Management of heavy menstrual bleeding in general practice. Curr Med Res Opin 2012;28899:1517-25.
Moradan S, Ghorbani R, Lotfi A. Agreement of histopathological findings of uterine curettage and hysterectomy specimens in women with abnormal uterine bleeding. Saudi Med J 2017;38(5):497-502.
Matteson KA, Rahn DD, Wheeler TL 2 nd, Casiano E, Siddiqui NY, Harvie HS, et al. Nonsurgical management of heavy menstrual bleeding: A systematic review. Obstet Gynecol 2013;121(3):632-43.
Munro MG. Clasification of menstrual bleeding dsiorders. Rev Endocr Metab Disord 2012;13(4):225-34.