Lidokain, Bupivakain ve Bunların Karışımının Meyve Sineklerinde Ömür Uzunluğu Üzerine Olan Etkisi

Bu çalışmada, farklı özelliklere sahip iki anestezik maddenin Drosophila melanogaster’de (meyve sineği)

Anahtar Kelimeler:

Bupivakain, Drosophila melanogaster, lidokain, ömür uzunluğu

The Effect of Lidocaine, Bupivacaine and Their Mixture on the Life-span of Fruit Flies

In this study, the effects of two anesthetic agents with different properties on the life span ofDrosophila melanogaster (fruit-fly) were investigated. There are very few studies on the effects of local anestheticsin this organism. For this purpose, different doses of the local anesthetic agents (0.0625 %, 0.125 %, 0.25 % and0.5 %) were applied to third stage larvae. The data obtained from control and test groups showed that there werechanges in the longevity of adults flies which grew from larvae to exposed to these agents. The present resultselucidated that although lidocaine and bupivacaine applications increased life span in parallel with an increasein dose in female individuals compared to control (p<0.05). The mixture of these two local anesthetics affectedadversely mean life span, maximum mean life span.

Keywords:

Bupivacaine, Drosophila melanogaster, lidocaine, the life span,

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