Koroner arter hastalığı ile Helicobacter pylori enfeksiyonu arasındaki ilişki

Helicobacter pylori (HP) enfeksiyonun koroner arter hastalığı (KAH) için bir risk faktörü olup olmadığını araştırma amaçlandı. Çalışmaya KAH ön tanısı ile koroner anjiografileri yapılan yaş ortalaması 52$\pm$7 olan 109'u erkek, 30'u kadın toplam 139 hasta alındı. Hastalardan koroner anjiografi öncesi venöz kan alınarak, HP seroaktivitesi (IgG ve Ig A) ile KAH arasındaki ilişki incelendi. Bu amaçla olgular 1 damar, 2 damar ve 3 damar lezyonu olan hastalar olmak üzere üç gruba ayrılarak, koroner anjiografisi normal olan grupla karşılaştırıldı. Olguların 35'inde 1 damar, 34'ünde 2 damar ve 35'inde 3 damar lezyonu vardı. Kontrol grubu ise 35 kişi idi. Koroner arterleri normal olan grupla; 1 damar, 2 damar ve 3 damar lezyonu olan gruplar karşılaştırıldığında, HP IgG ve IgA antikor cevabı bakımından istatistiki olarak anlamlı bir farklılık bulunamadı (p>0,05). Bu çalışmada, koroner anjiografi ile KAH tesbit edilen hastalarda HP pozitifliği kontrol grubundan farklı bulunmadı. Bu da bize HP enfeksiyonunun KAH için bağımsız bir risk faktörü olmadığını düşündürdü.

The relationship between coronary artery disease and Helicobacter pylori

Major aim is to investigate Helicobacter pylori (HP) infection as a risk factor for coronary artery disease (CAD). In this study 139 patients (aged 30 female, 109 male; aged mean 52$\pm$7) who performed coronary angiography with initial diagnosis of CAD were investigated. Just before coronary angiography, venous blood was taken from the patients and the relationship between CAD and HP seroactivity (IgG ve Ig A) was examined. For this reason the patients were separated into 3 groups who have 1, 2 and 3 vessel lesions and the results were compared with the group who have normal coronary angiography. 35 patients had 1 vessel, 34 had 2 vessel and 35 had 3 vessel disease. The control group consisted of 35 subjects. When the group with normal coronary arteries were compared with the groups of 1, 2 and 3 vessel lesions, no statistically significant difference was obtained considering HP, IgG and IgA antibody response (p>0.05). In this study HP positivity didn't show any difference between the control group and coronary angiographically proven CAD group which suggested that HP infection was not an independent risk factor for CAD.

Kaynakça

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