Sütçocuklarında atopik dermatit ağırlığı ile serum TSLP ve TARC düzeyleri arasındaki ilişki

Amaç: Atopik dermatit tanılı sütçocuklarında serum TSLP ve TARC düzeylerinin ölçülmesi, hastalığın ağırlığı ile ilişkisinin araştırılması ve elde edilen sonuçların sağlıklı çocukların değerleri ile karşılaştırılması amaçlanmıştır. Yöntemler: Atopik dermatitin ağırlığı SCORing atopik dermatitis score (SCORAD) ile belirlendi. Atopik dermatitli çocuklarda atopik durumun değerlendirilmesi için deri prik testi uygulandı. Tüm katılımcılarda serum TSLP ve TARC düzeyi ölçüldü.Bulgular: Atopik dermatitli çocukların serum TSLP ve TARC düzeyleri sağlıklı kontrollerin değerlerinden anlamlı olarak yüksekti (sırasıyla, p=0,001, p=0,004). Atopik dermatitin ağırlığı ile serum TARC düzeyleri arasında ilişki var iken (p=0,014), TSLP ile hastalığın ağırlığı arasında ilişki saptanmadı (p=0,80). Atopik dermatitli çocuklarda TSLP ve TARC arasında korrelasyon saptanmaz iken (p=0,576), TARC ile hastanın yaşı arasında negatif yönde orta düzeyde korrelasyon saptandı (r= -0,426, p=0,038). Receiver operating characteristic (ROC) analizinde serum TSLP düzeyinin atopik dermatit varlığını öngörmesi için hesaplanan Eğri Altında Kalan Alan (Area Under Curve, AUC) 0,780 [%95 Güven Aralığı (0,640 - 0,885) p

The relationship between serum TSLP and TARC levels with the severity of atopic dermatitis in infants

Objective: The aim of the study is to measure serum levels of TSLP and TARC, to evaluate their relationships with disease severity and to compare the results with the levels of healthy children. Methods: The severity of atopic dermatitis was determined by scoring atopic dermatitis score (SCORAD). Skin prick test was performed to evaluate atopic status. Serum TSLP and TARC levels were measured in all participants. Results: Serum levels of TSLP and TARC were significantly higher in children with atopic dermatitis than those of healthy controls (p=0.001, p=0.004, respectively). While, there was an association between disease severity and serum TARC levels (p=0.014), no association was found between TSLP, and severity of disease (p=0.80). There was no correlation between TSLP and TARC (p=0.576), however, TARC was negatively correlated with age of the children with atopic dermatitis (r= -0.426, p=0.038). In receiver operating characteristic (ROC) analysis, area under Curve (AUC) which was calculated serum TSLP level in the prediction of the presence of atopic dermatitis was 0.780 [95% confidence interval (0.640-0.885), p<0.001]. The sensitivity of serum TSLP level of 30,41 pg/mL was 72% and the specificity 84% in the prediction of the presence of atopic dermatitis. The AUC was 0,738 [95% Confident Interval (0,595-0,852), p=0.0007] for serum TARC level to estimate atopic dermatitis. The sensitivity and specificity of serum TARC level of 242.68 pg/mL were 72%, and 68% in the prediction of atopic dermatitis. Conclusion: Serum levels of TSLP and TARC are closely related with the presence of atopic dermatitis in infants. Serum TARC level is associated with the severity of atopic dermatitis.

Kaynakça

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