OBEZ OLGULARDA ÜRİK ASİT DÜZEYİNİN UYKUDA SOLUNUM BOZUKLUKLARI İLE İLİŞKİSİ

Amaç: Bu çalışmada obez ve uyku ile ilişkili solunum bozuklukları (UİSB) olan olgularda serum ürik asit (ÜA) düzeyinin obstruktif uyku apne (OUA) şiddeti, nokturnal hipoksemi (NH) ve obezite hipoventilasyon sendromu (OHS) ile ilişkisi araştırıldı. Gereç ve Yöntem: Uyku laboratuarına başvuran vücut kitle indeksi (VKİ) ≥30 kg/m2 olan polisomnografi ile UİSB saptanan tüm olgular çalışmaya alındı. Demografik özellikler, antropometrik ölçümler ve serum ÜA düzeyleri kaydedildi. Apne-hipopne indeksi (AHİ) ve ODİ (oksijen desaturasyon indeksi) hesaplandı. AHİ 5-14 olay/sa hafif, 15-29 olay/sa orta ve ≥30 olay/sa ağır şiddette OUA olarak değerlendirildi. Nokturnal SpO2<%90 olan sure ≥%30 ise NH kabul edildi. PaCO2>45 mmHg ise OHS tanısı koyuldu. Bulgular: Çalışmaya 159 UİSB olan olgu (79 kadın, 80 erkek, yaş: 50,0±10,5 yıl, VKİ: 40,1±5,7 kg/m2) dahil edildi. Olguların 76'sında OHS ve 83'ün de saf OUA tanısı mevcuttu. NH %25,8'inde (n=41) saptandı. NH olanlarda ÜA düzeyi anlamlı olarak yüksekti (6,22±1,37 mg/dl, 5,67±1,51 mg/dl, p=0,008). OHS olgularında ÜA düzeyi saf OUA olguları ile benzerdi (5,91±1,25 mg/dl, 5,72±1,68 mg/dl, p=0,1). OUA şiddeti arttıkça ÜA düzeyi artmaktaydı (hafif: 5,03±1,41 mg/dl, orta: 5,46±1,55 mg/ dl, ağır: 6,19±1,8 mg/dl, p=0,039). Erkek OUA olgularında ÜA düzeyleri daha yüksekti (6,86±1,64 mg/dl, 4,84±1,10 mg/dl, p<0,001). ÜA düzeyi boyun çevresi (r=0,366, p<0,001), bel/kalça oranı (r=0,358, p<0,001), OUA şiddeti (r=0,224, p=0,005), AHİ (r=0,250, p=0,001), ODİ (r=291, p<0,001), nokturnal SpO2<%90 geçen süre (r=0,228, p=0,004) ile korelasyon göstermekteydi. Erkek cinsiyet, NH ve bel/kalça oranı ÜA düzeyi ile bağımsız ilişkili faktörler olarak bulundu (sırasıyla; p<0,001, p=0,03, p=0,03). Sonuç: UİSB olan obez olgularda, yüksek serum ÜA düzeyleri erkek cinsiyet, NH ve OUA şiddeti ile ilişkili bulunmuştur.

RELATIONSHIP BETWEEN SERUM URIC ACID LEVELS AND SLEEP-RELATED BREATHING DISORDERS IN OBESE SUBJECTS

Objective: We examined the serum uric acid (UA) levels among patients with sleep-related breathing disorders (SRBD) and the relationship between UA levels and obstructive sleep apnea (OSA) severity, nocturnal hypoxemia (NH) and obesity hypoventilation syndrome (OHS). Material and Method: Subjects with body mass index (BMI) ≥30 kg/m2 who, according to polysomnography results, have SRBD were included. Demographics, anthropometric measurements and serum UA were recorded. The apnea-hypopnea index (AHI) and oxygen desaturation index (ODI) were recorded. The OSA severity was graded as mild (AHI 5-14 events/hour), moderate (AHI 15-29 events/hour) or severe (AHI ≥30 events/hour). NH was considered when sleep time spent with SpO2<90% was ≥30%. PaCO2>45 mmHg was considered OHS. Results: The study included 159 patients with SRBD (79 female, 80 males, age: 50.0±10.5 years, BMI: 40.1±5.7 kg/m2). Seventy- six had OHS and 83 had pure OSA. NH was detected in 25.8% of patients. UA levels were higher in subjects with NH (6.22±1.37 mg/dl, 5.67±1.51 mg/dl, p=0.008). UA levels were similar in patients with OHS and pure OSA (5.91±1.25 mg/dl, 5.72±1.68 mg/ dl, p=0.1). UA levels increased as OSA severity increased (mild: 5.03±1.41 mg/dl, moderate: 5.46±1.55 mg/dl, severe: 6.19±1.8 mg/dl, p=0.039). UA levels were higher in males with OSA (6.86±1.64 mg/dl, 4.84±1.10 mg/dl, p<0.001). UA levels were correlated with neck circumference (r=0.366, p<0.001), waist/ hip ratio (r=0.358, p<0.001), OSA severity (r=0.224, p=0.005), AHI (r=0.250, p=0.001), ODI (r=291, p<0.001) and sleep time with SpO2<90% (r=0.228, p=0.004). Male gender, waist/hip ratio and NH were factors independently related with UA levels (retrospectively; p<0.001, p=0.03, p=0.03). Conclusion: In obese subjects with SRBD, serum UA levels were associated with male gender, NH and OSA severity.

Kaynakça

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Kaynak Göster

Bibtex @araştırma makalesi { iuitfd852959, journal = {Journal of Istanbul Faculty of Medicine}, issn = {}, eissn = {1305-6441}, address = {}, publisher = {İstanbul Üniversitesi}, year = {2021}, volume = {84}, pages = {208 - 213}, doi = {10.26650/IUITFD.2020.822959}, title = {RELATIONSHIP BETWEEN SERUM URIC ACID LEVELS AND SLEEP-RELATED BREATHING DISORDERS IN OBESE SUBJECTS}, key = {cite}, author = {Pıhtılı, Aylin and Bingöl, Züleyha and Kıyan, Esen} }
APA Pıhtılı, A , Bingöl, Z , Kıyan, E . (2021). RELATIONSHIP BETWEEN SERUM URIC ACID LEVELS AND SLEEP-RELATED BREATHING DISORDERS IN OBESE SUBJECTS . Journal of Istanbul Faculty of Medicine , 84 (2) , 208-213 . DOI: 10.26650/IUITFD.2020.822959
MLA Pıhtılı, A , Bingöl, Z , Kıyan, E . "RELATIONSHIP BETWEEN SERUM URIC ACID LEVELS AND SLEEP-RELATED BREATHING DISORDERS IN OBESE SUBJECTS" . Journal of Istanbul Faculty of Medicine 84 (2021 ): 208-213 <https://dergipark.org.tr/tr/pub/iuitfd/issue/62206/852959>
Chicago Pıhtılı, A , Bingöl, Z , Kıyan, E . "RELATIONSHIP BETWEEN SERUM URIC ACID LEVELS AND SLEEP-RELATED BREATHING DISORDERS IN OBESE SUBJECTS". Journal of Istanbul Faculty of Medicine 84 (2021 ): 208-213
RIS TY - JOUR T1 - RELATIONSHIP BETWEEN SERUM URIC ACID LEVELS AND SLEEP-RELATED BREATHING DISORDERS IN OBESE SUBJECTS AU - Aylin Pıhtılı , Züleyha Bingöl , Esen Kıyan Y1 - 2021 PY - 2021 N1 - doi: 10.26650/IUITFD.2020.822959 DO - 10.26650/IUITFD.2020.822959 T2 - Journal of Istanbul Faculty of Medicine JF - Journal JO - JOR SP - 208 EP - 213 VL - 84 IS - 2 SN - -1305-6441 M3 - doi: 10.26650/IUITFD.2020.822959 UR - https://doi.org/10.26650/IUITFD.2020.822959 Y2 - 2021 ER -
EndNote %0 İstanbul Tıp Fakültesi Dergisi RELATIONSHIP BETWEEN SERUM URIC ACID LEVELS AND SLEEP-RELATED BREATHING DISORDERS IN OBESE SUBJECTS %A Aylin Pıhtılı , Züleyha Bingöl , Esen Kıyan %T RELATIONSHIP BETWEEN SERUM URIC ACID LEVELS AND SLEEP-RELATED BREATHING DISORDERS IN OBESE SUBJECTS %D 2021 %J Journal of Istanbul Faculty of Medicine %P -1305-6441 %V 84 %N 2 %R doi: 10.26650/IUITFD.2020.822959 %U 10.26650/IUITFD.2020.822959
ISNAD Pıhtılı, Aylin , Bingöl, Züleyha , Kıyan, Esen . "RELATIONSHIP BETWEEN SERUM URIC ACID LEVELS AND SLEEP-RELATED BREATHING DISORDERS IN OBESE SUBJECTS". Journal of Istanbul Faculty of Medicine 84 / 2 (Nisan 2021): 208-213 . https://doi.org/10.26650/IUITFD.2020.822959
AMA Pıhtılı A , Bingöl Z , Kıyan E . RELATIONSHIP BETWEEN SERUM URIC ACID LEVELS AND SLEEP-RELATED BREATHING DISORDERS IN OBESE SUBJECTS. İst Tıp Fak Derg. 2021; 84(2): 208-213.
Vancouver Pıhtılı A , Bingöl Z , Kıyan E . RELATIONSHIP BETWEEN SERUM URIC ACID LEVELS AND SLEEP-RELATED BREATHING DISORDERS IN OBESE SUBJECTS. Journal of Istanbul Faculty of Medicine. 2021; 84(2): 208-213.
IEEE A. Pıhtılı , Z. Bingöl ve E. Kıyan , "RELATIONSHIP BETWEEN SERUM URIC ACID LEVELS AND SLEEP-RELATED BREATHING DISORDERS IN OBESE SUBJECTS", Journal of Istanbul Faculty of Medicine, c. 84, sayı. 2, ss. 208-213, Nis. 2021, doi:10.26650/IUITFD.2020.822959

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