KRONİK BÖBREK HASTALIĞINDA ARTERİYEL SERTLİĞİN BÖBREK PROGRESYONU VE MORTALİTE ÜZERİNE ETKİSİ

Amaç: Nabız dalga hızı (PWV), vasküler kalsifikasyon tanısında kullanılan elektron beam bilgisayarlı tomografi (EBCT) ile korelasyon gösterir ve kronik böbrek hastalığında (KBH) arteriyel sertlik değerlendirmesi için sıklıkla kullanılır. Literatürde KBH’ da arteriyel sertlik ile böbrek progresyonu ve mortalite arasındaki ilişki hakkında çok az çalışma vardır. Bu çalışmada KBH’da arteriyel sertlik ile böbrek hastalığının progresyonu ve mortalite arasındaki ilişkiyi araştırdık. Gereç ve Yöntem: Aralık 2014-Haziran 2015 tarihleri arasında nefroloji polikliniğine başvuran evre 3-5 kronik böbrek hastaları çalışmaya alındı. Hastalar en az dört yıl takip edildi. Birincil sonlanım noktaları bir renal replasman tedavisi başlanması (renal transplantasyon, hemodiyaliz veya periton diyalizi) ve ölümdür. Nabız dalga hızı (PWV) Mobil-O-Graph NG (Stemberg Germany Stolberg Germany) arteriograf cihazı kullanılarak ölçüldü. Bulgular: Çalışma 4 yıl boyunca düzenli kontrole gelen 194 hasta ile tamamlandı. Bu süre zarfında 194 hastanın 89’unda renal replasman tedavisi (72 hemodiyaliz, 17 renal transplantasyon) gerekti ve 15’i öldü. 90 hasta nefroloji polikliniğinde prediyaliz KBH’sı olarak izlenmektedir. Artan PWV, mortalitenin bağımsız bir prediktif belirteci olarak tespit edildi. Sonuç: Bu çalışmada, PWV’deki artışın mortalitenin bağımsız bir belirteci olduğunu bulduk. Bu anlamda, PWV’nin izlenmesinin ve bu yönde önlemler alınmasının arteriyel sertliğin mortalite üzerindeki etkisini azaltabileceğini gösterdik.

THE EFFECT OF ARTERIAL STIFFNESS ON DISEASE PROGRESSION AND MORTALITY IN CHRONIC KIDNEY PATIENTS

Objective: Pulse wave velocity (PWV) is frequently used for arterial stiffness assessment in chronic renal disease (CRD). There are very few studies in the literature about the relationship between arterial stiffness and renal progression leading to mortality in CRD. Herein, we searched the relationship between arterial stiffness, and progression of kidney disease, leading to mortality in CRD patients. Methods: 194 stage 3-5 CRD patients were included in the study. The patients were followed at least four years. The primary endpoints were initiation a renal replacement treatment and death. PWV was measured using the Mobil-O-Graph NG arteriography device. Results: The study was completed with 194 patients within four years. During this period, out of 194 patients, 89 needed a renal replacement treatment (72 hemodialysis patients, 17 renal transplantation) and 15 died. Ninety of them are still being followed as predialysis CKD patient in the nephrology outpatient clinic. Increased PWV was detected as an independent predictive marker of mortality. Conclusion: Our study demonstrated that PWV might be an independent predictor of mortality. In this sense, monitoring the PWV and taking measures in this direction can reduce the effect of arterial stiffness on mortality.

Kaynakça

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Kaynak Göster

Bibtex @araştırma makalesi { iuitfd892894, journal = {Journal of Istanbul Faculty of Medicine}, issn = {}, eissn = {1305-6441}, address = {}, publisher = {İstanbul Üniversitesi}, year = {2021}, volume = {84}, pages = {214 - 220}, doi = {10.26650/IUITFD.2020.0060}, title = {THE EFFECT OF ARTERIAL STIFFNESS ON DISEASE PROGRESSION AND MORTALITY IN CHRONIC KIDNEY PATIENTS}, key = {cite}, author = {Erkuş, Edip and Karaköse, Süleyman and Özkan Kurtgöz, Pervin and Gençer, Vedat and Güney, İbrahim} }
APA Erkuş, E , Karaköse, S , Özkan Kurtgöz, P , Gençer, V , Güney, İ . (2021). THE EFFECT OF ARTERIAL STIFFNESS ON DISEASE PROGRESSION AND MORTALITY IN CHRONIC KIDNEY PATIENTS . Journal of Istanbul Faculty of Medicine , 84 (2) , 214-220 . DOI: 10.26650/IUITFD.2020.0060
MLA Erkuş, E , Karaköse, S , Özkan Kurtgöz, P , Gençer, V , Güney, İ . "THE EFFECT OF ARTERIAL STIFFNESS ON DISEASE PROGRESSION AND MORTALITY IN CHRONIC KIDNEY PATIENTS" . Journal of Istanbul Faculty of Medicine 84 (2021 ): 214-220 <https://dergipark.org.tr/tr/pub/iuitfd/issue/62206/892894>
Chicago Erkuş, E , Karaköse, S , Özkan Kurtgöz, P , Gençer, V , Güney, İ . "THE EFFECT OF ARTERIAL STIFFNESS ON DISEASE PROGRESSION AND MORTALITY IN CHRONIC KIDNEY PATIENTS". Journal of Istanbul Faculty of Medicine 84 (2021 ): 214-220
RIS TY - JOUR T1 - THE EFFECT OF ARTERIAL STIFFNESS ON DISEASE PROGRESSION AND MORTALITY IN CHRONIC KIDNEY PATIENTS AU - Edip Erkuş , Süleyman Karaköse , Pervin Özkan Kurtgöz , Vedat Gençer , İbrahim Güney Y1 - 2021 PY - 2021 N1 - doi: 10.26650/IUITFD.2020.0060 DO - 10.26650/IUITFD.2020.0060 T2 - Journal of Istanbul Faculty of Medicine JF - Journal JO - JOR SP - 214 EP - 220 VL - 84 IS - 2 SN - -1305-6441 M3 - doi: 10.26650/IUITFD.2020.0060 UR - https://doi.org/10.26650/IUITFD.2020.0060 Y2 - 2020 ER -
EndNote %0 İstanbul Tıp Fakültesi Dergisi THE EFFECT OF ARTERIAL STIFFNESS ON DISEASE PROGRESSION AND MORTALITY IN CHRONIC KIDNEY PATIENTS %A Edip Erkuş , Süleyman Karaköse , Pervin Özkan Kurtgöz , Vedat Gençer , İbrahim Güney %T THE EFFECT OF ARTERIAL STIFFNESS ON DISEASE PROGRESSION AND MORTALITY IN CHRONIC KIDNEY PATIENTS %D 2021 %J Journal of Istanbul Faculty of Medicine %P -1305-6441 %V 84 %N 2 %R doi: 10.26650/IUITFD.2020.0060 %U 10.26650/IUITFD.2020.0060
ISNAD Erkuş, Edip , Karaköse, Süleyman , Özkan Kurtgöz, Pervin , Gençer, Vedat , Güney, İbrahim . "THE EFFECT OF ARTERIAL STIFFNESS ON DISEASE PROGRESSION AND MORTALITY IN CHRONIC KIDNEY PATIENTS". Journal of Istanbul Faculty of Medicine 84 / 2 (Nisan 2021): 214-220 . https://doi.org/10.26650/IUITFD.2020.0060
AMA Erkuş E , Karaköse S , Özkan Kurtgöz P , Gençer V , Güney İ . THE EFFECT OF ARTERIAL STIFFNESS ON DISEASE PROGRESSION AND MORTALITY IN CHRONIC KIDNEY PATIENTS. İst Tıp Fak Derg. 2021; 84(2): 214-220.
Vancouver Erkuş E , Karaköse S , Özkan Kurtgöz P , Gençer V , Güney İ . THE EFFECT OF ARTERIAL STIFFNESS ON DISEASE PROGRESSION AND MORTALITY IN CHRONIC KIDNEY PATIENTS. Journal of Istanbul Faculty of Medicine. 2021; 84(2): 214-220.
IEEE E. Erkuş , S. Karaköse , P. Özkan Kurtgöz , V. Gençer ve İ. Güney , "THE EFFECT OF ARTERIAL STIFFNESS ON DISEASE PROGRESSION AND MORTALITY IN CHRONIC KIDNEY PATIENTS", Journal of Istanbul Faculty of Medicine, c. 84, sayı. 2, ss. 214-220, Nis. 2021, doi:10.26650/IUITFD.2020.0060

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