Hikmet KELEŞ, Mehmet Eray ALCIGIR, Zafer OZYILDIZ, Mehmet Fatih BOZKURT

Sığır İdrar Keselerindeki Non-neoplastik Lezyonların Patomorfolojik Özellikleri

Non-neoplastik epitelyal ve stromal değişiklikler, idrar kesesinin premalign neoplastik gelişimlerinin erken evresinde prognostik olabilir. Bu lezyonların tanısı ve histolojik sınıflandırması, hem insan hem de veteriner hekimlikte önleme ve tedavi için değerli bilgiler vermektedir. Türkiye’de, diğer hayvanlarda az sayıda olgu görülmesine rağmen sığır idrar kesesi lezyonlarına yüksek oranlarda rastlanmaktadır. Yıllara dayalı yeterli deneyimlerimiz ve saha çalışmalarımıza göre, uzun vadede eğrelti otu tüketen büyükbaş hayvanların idrar keselerinde yangısal ve neoplastik patolojiler kolaylıkla gelişebilir. Bu çalışmada, başlıca epitelyal, stromal, damarsal ve yangısal karakterli lezyonları içeren non-neoplastik olgular tanımlanmış ve ayrı ayrı açıklanmıştır. İdrar kesesi epitelinde dejeneratif, deskuamatif, kistik, hiperplastik ve metaplastik lezyonlar belirgin olarak bulundu. Ardışık lezyonlar stromal değişiklikler ve dolaşım problemleri ile karakterize damarsal lezyonları da içeriyordu. Bunlara eşlik eden, dikkate değer mononükleer hücre infiltrasyonları çok sayıda vakada bulundu. Sonuç olarak, bu tür non-neoplastik lezyonların en azından neoplastik lezyonlar kadar önemli olduğu düşünülmelidir, çünkü lezyonlar premalign neoplastik transformasyon sırasında bir risk oluşturabilir.

Anahtar Kelimeler:

Sığır, Histopatoloji, Non-neoplastik değişiklikler, İdrar kesesi

Pathomorphologic Characteristics of Non-Neoplastic Lesions in Bovine Urinary Bladders

Non-neoplastic epithelial and stromal changes might be prognostic in early phase of premalignant neoplastic developments of urinary bladder. In this regard, diagnosis and histological classification of these lesions give valuable knowledge for prevention and treatment in both human and veterinary medicine. In Turkey, bovine urinary bladder lesions have been encountered in great ratio even though the small numbers of cases have been observed in other animals. According to our great experiences and field-studies for years concentrating on the topic, inflammatory and neoplastic of pathologies in urinary bladders might be easily developed after long term Bracken fern-consuming cattle. In current study, non-neoplastic cases including mainly epithelial, stromal, vascular, and inflammatory characteristic lesions were identified and described separately. Degenerative, desquamative, cystic, hyperplastic, and metaplastic lesions were found prominently in urinary bladder epithelium. Consecutive lesions comprised stromal changes and vascular lesions characterized with circulatory problems. Accompanying those, remarkable mononuclear cell infiltrations were found in a lot of cases. In conclusion, such kind of non-neoplastic lesions at least should be considered as important as neoplastic lesions because the lesions can have a risk in course of premalignant neoplastic transformation.

Keywords:

Cow, Histopathology, Non-neoplastic changes, Urinary bladder,

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