Necdet SAĞLAM, Zeynep KARAHALİLOĞLU, Emir Baki DENKBAŞ, Ebru ERDAL, Eylem GÜVEN, Dilek CANDAN, Mesut ŞAM

Antibacterial agent loaded fungal polymer for use as a wound dressing

Bu çalışma beyaz çürükçül bir fungal suş olan Trametes Versicolor’ın ürettiği ekstraselüler polisakkaritten üç-boyutlu mikrogözenekli yapıya sahip yeni bir yara örtü malzemesinin hazırlanması ve karakterizasyonunu kapsamaktadır. Hazırlama prosedürü esnasında model bir antibiyotik (siprofloksasin) yara örtü malzemelerine yüklenmiştir. Elde edilen yara örtü malzemeleri 4 ana bölüm altında incelenmiştir. İlk bölümde taramalı elektron mikroskobu kullanılarak morfolojik değerlendirmeler yapılmış olup elde edilen görüntüler sonucunda yara örtü malzemelerinin birbirleri ile bağlantılı yüksek gözenekliliğe sahip olduğu gözlenmiştir. Antibakteriyel ajan yüklü yara örtü malzemeleri ayrıca şişme ve in vitro ilaç salımı çalışmaları, biyobozunurluk testleri yapılarak karakterize edilmiştir. Elde edilen sonuçlar fungal polimerden elde edilen antibakteriyel ajan yüklü yara örtü malzemelerinin yeni nesil yara örtü malzemesi olarak dermal yaraların tedavisinde iyi bir potansiyel olusturabileceğini göstermektedir.

Yara örtü malzemesi olarak kullanılmak üzere antibakteriyel ajan yüklü fungal polimer

This study is mainly concerned with the preparation and characterization of a novel wound dressing, in the form of three-dimensional micro-porous structure, from extracellular polysaccharide produced by Trametes Versicolor, a white-rot basidiomycete. A model antibiotic (i.e., ciprofloxacin) was loaded into these wound dressings in the preparation procedure. The prepared wound dressings were investigated and evaluated in four main sections. In the first part, morphological evaluations were made by using scanning electron microscopy and the obtained images revealed that the wound dressings were having highly porous structure with interconnected pores. Antibacterial agent loaded-wound dressings were also investigated with swelling behavior, in vitro drug release and biodegradation studies. Obtained results showed that wound dressings from fungal polymer including antibacterial agent could provide great potential in the treatment of dermal wounds as a new kind of wound dressing material.

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