Kemerin

Modern hayat tarzı, teknolojiye paralel olarak değişen yemek alışkanlıkları ve her geçen gün daha sık maruz kalınan stres koşulları aşırı kilo artışı, insülin rezistansı, hipertansiyon,Tip 2 diyabet gibi hastalıklara yakalanma riskini arttırmaktadır. Adipoz doku yağ depolama görevi yanında birçok hastalıkla ilişkili olduğu bilinen adipokinlerin sentez ve salgılanmasından sorumlu endokrin bir organdır. Yakın zamanda adipoz dokudan salınan bir adipokin çeşidi olduğu tespit edilen kemerin başta kemoatraktant fonksiyonu olmak üzere; adipogenezis, anjiogenezis ve glukoz homeostazı gibi birçok metabolik olayla ilişki bir proteindir. Adipoz dokudan inaktif formda salınan kemerin aktif olduğu fonksiyonel formlarına çeşitli proteazlarla karboksil terminalindeki aminoasitlerin uzaklaştırılmasıyla dönüşebilir. Kemerin seviyesinin inflamasyon, diyabet, metabolik sendrom, kardiyovasküler hastalıklı bireylerde sağlıklı kişilere göre daha yüksek olması gelecekte bu hastalıkların ön belirteci olarak teşhis ve kontrolünde yeni bir teröpatik yaklaşım sağlayabileceği savunulmaktadır. Bu derlemenin amacı farklı metabolik yollarda önemli düzenleyici roller üstlenen kemerinin yapısı, görevleri ve hastalıklarla ilişkisinden bahsetmektir.

Anahtar Kelimeler:

Adipokinler, Kemoatraktant, Kemerin, Kemokin Benzeri Reseptör-1

Chemerin

Modern life style, food habits which changing technology in paralel and with each passing day more frequent exposured to stress conditions increases the risk of diseases such as high weight gain, insulin resistance, hypertension, Type 2 diabetes. Adipose tissue is an endocrine organ, which is responsible for the function of fat storage and, also the synthesis and secretion of adipokines that is known the relation with many diseases. Chemerin is a protein, has been recently determined that a kind of adipokine and secreted by the adipose tissue and has the main function of chemoattractant and is associated with a lot of metabolic pathways including adipogenezis, angiogenesis and glucose homeostasis. Chemerin, is secreted by inactive forms from adipose tissue, may be turned to active functional forms with the removal of the carboxyl terminal amino acids by a variety of proteases. In a result, the people with inflammation, diabetes, metabolic syndrome, cardiovascular disease may have higher the level of chemerin comparing to the healthy people, in the future is suggest that may provide a new therapeutic approach for the diagnosis and control as predictors of these disease. To aim of this review is shown that the structure and the function of chemerin, which has important regulator roles on different metabolic pathways and to explain the relation with diseases.

Keywords:

Adipokines, Chemoatractant, Chemerin, Chemokin-Like Receptor-1,

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