Evaluation of mandibular bone structure in sickle cell anemia patients

Orak hücreli anemi (OHA) ailesel kaynaklı hemoglobinopatidir. OHA ve osteomiyelit başlangıcına dair birçok radyografik bulgu vardır. Retrospektif olarak Konik Işınlı Bilgisayarlı Tomografi (KIBT) ile 10 hasta değerlendirildi. KIBT ile elde edilen DICOM verileri OHA hastalarında mandibular kemik yapıdaki değişimleri değerlendirmek üzere üçüncü bir yazılıma transfer edildi. Hastalarda kemik dansitesi, trabeküler kalınlık, trabeküler ayrılma, trabeküler sayı, fraktal boyut, kapalı por sayısı, kapalı por hacmi, kapalı por yüzeyi, kapalı porozite, açık por hacmi, açık porozite, por boşluğunun total hacmi ve total porozite gibi kriterler değerlendirildi. Ortalama fd değeri sağlikli bireylerden daha düşük bulundu. SCA hastaları ile sağlıklı bireylerin FD değerleri arasındaki fark istatistiksel olarak anlamlı olarak bulundu (p

Orak Hücreli Anemi Hastalarında Mandibular Kemik Yapının Değerlendirilmesi

Sickle cell anemia (SCA) is a familial hemoglobinopathy. There are several radiographic findings regarding both SCA and onset of osteomyelitis. Cone Beam CT examinations of 10 patients were evaluated retrospectively. The DICOM data from CBCT examinations were transferred to a 3rd party software in order to evaluate the mandibular bone changes in SCA patients. Following parameters were evaluated; Bone surface density, Trabecular thickness, Trabecular separation, Trabecular number, Fractal dimension, Number of closed pores, Volume of closed pores, Surface of closed pores, Closed porosity, Volume of open pore space, Open porosity, Total volume of pore space, Total porosity. The mean of FD values was found to significantly lower than healthy individuals. Statistical analysis of FD values barely reached to significance between SCA patients and the healthy individuals (p<0,05). It was also found that trabecular thickness was also significantly higher than healthy patients (p<0,05). Our findings revealed decreased FD with SCA, further studies should be done with larger groups in order to define optimal parameters for SCA patients in mandible.

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