The association between platelet indices and clinical parameters in recurrent pregnancy loss

AMAÇ: Tekrarlayan gebelik kayıplarına (TGK) neden olan faktörler çeşitlilik göstermektedir. Hiperkoagülasyon TGK’na sebep olan ve tedavi edilebilen etkenlerden biridir. Platelet (PLT) sayısı, ortalama PLT hacmi (MPV), PLT dağılım aralığı (PDW) ve PLT crit trombosit indeksleridir ve artmış trombosit agregasyonunun parametreleri olabilirler. Bu çalışmada amaç, TGK olan hastalarda ve sağlıklı bireylerde PLT sayısı, MPV, PDW ve PCT değerlerinin saptanması ve karşılaştırılmasıdır. GEREÇ VE YÖNTEM: Çalışmaya TGK olan 39 hasta ve 40 sağlıklı kadın alınmıştır. Tüm katılan bireylerde PLT sayısı, MPV, PDW ve PCT değerleri karşılaştırılmıştır. BULGULAR: Sağlıklı konrollerle karşılaştırıldığında, TGK olan kadınlarda PLT sayısı, MPV, PDW ve PCT değerlerinde herhangi bir istatistiksel anlamlı fark saptanmamıştır. (p>0,05) SONUÇ: Trombosit indeksleri TGK olan hastalarda henüz tatmin edici değere sahip değildir ve klinik pratikte rutin olarak kullanılması pek uygun gibi gözükmemektedir.

Tekrarlayan gebelik kayıplarında trombositlerin rolü nedir?

OBJECTIVE: Etiology of recurrent pregnancy loss (RPL) is variable. Hypercoagulability is one of the treatable conditions causing RPL. Platelet (PLT) count, mean PLT volume (MPV), PLT distribution width (PDW) and plateletcrit (PCT) are platelet indices and may be markers for increased platelet aggregabil- ity. In the present study, we aimed to determine and compare PLT count, MPV, PDW and PCT between patients with RPL and healthy controls. STUDY DESIGN: A total number of 39 patients with RPL and 40 healthy controls were enrolled in the research. PLT count, MPV, PDW and PCT values were compared between the patients and the controls. RESULTS: There were no statisti¬cally significant differences in number of PLTs, MPV, PCT and PDW values between women with RPL and healthy women (p> 0.05). CONCLUSION: Thrombocyte indices have still an unsatisfactory value in RPL and it seems that they are not appropriate for routine clinical practice regarding RPL.

Kaynakça

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