A Rare Coexistence in an Infertile Woman: Ligneous Disease in Cervix and Conjunctiva

Dişi genital yolunu tutan lignöz hastalık çok nadir bir durumdur. Bu olgu sunumunda disparoni, postkoital kanama ve infertilite şikayetleriyle kliniğimize başvuran bir hastayı bildirmekteyiz. Spekulum muayenesinde ostium etrafında beyaz plaklar ve kanamalı lezyonlar olan nulliparöz bir serviks saptandı. Servikal lezyonlardan çoklu biyopsiler yapıldı. Histopatolojik tanı lignöz servisit ve düşük dereceli intraepitelyal lezyon şeklinde geldi. Hastalığın özellikleri göz önünde bulundurularak, konjuktiva muayenesi ve biyopsi yapıldı. Servikal lezyonların mikroskobik özelliklerine benzer bulgular saptandı ve lignöz konjuktivit olarak raporlandı. Takip eden 6 ayda siklosporin ve oral kontraseptif kullanan hastanın oküler ve genital lezyonlarında bir gelişme saptanmadı.

İnfertil Kadında Nadir Bir Birliktelik: Serviks ve Konjunktivada Lignöz Hastalık

Ligneous disease involving the female genital tract is a very rare entity. We present a case of a patient who admitted to our clinic with the complaints of dyspareunia, postcoital bleeding and infertility. On speculum examination a nulliparous cervix with white plaques and hemorrhagic lesions around ostium were seen. Multiple samples were taken from the cervical lesions and histopathologic diagnosis was ligneous cervicitis and low grade cervical intraepithelial lesion. According to the characteristics of the disease, a conjunctival examination and biopsy were performed. Similar microscopic features in cervix were also determined and reported as ligneous conjunctivitis. She used cyclosporine and oral contraceptives in the following six months but there was no improvement on either ocular or genital lesions.

Kaynakça

1. Pantanowitz L, Bauer K, Tefs K, Schuster V, Balogh K, Pilch BZ, et al. Ligneous (pseudomembranous) inflamma?tion involving the female genital tract associated with type-1 plasminogen deficiency. Int J Gynecol Pathol 2005;23:292-5.

2. Deen S, Duncan TJ, Hammond RH. Ligneous cervicitis; is it the emperor's new clothes? Case report and different analysis of aetiology. Histopathology 2006;49:198-9.

3. Pantanowitz L, Fraser JL. Ligneous change of the female genital tract. Fertil Steril 2002;78:1123-4.

4. Borel MG. Un nouveau syndrome palpebral. Bull Soc Ophthalmol Fr 1933; 46:168-80.

5. Schuster V, Seregard S. Ligneous conjunctivitis. Surv Ophthalmol 2003;48:369-88.

6. Altinkaya SO, Uzunlar O, Talas BB, Ozat M, Bilge U. Ligneous cervicovaginitis. Taiwan J Obstet Gynecol 2008;47:363-6.

7. Pantanowitz L. Ligneous cervicitis. BJOG 2004;111: 635-6.

8. Ny A, Leonardsson G, Hagglund AC, Hägglöf P, Ploplis VA, Carmeliet P, et al. Ovulation in plasminogen deficient mice. Endocrinology 1999;140:5030- 5.

9. Bateman JB, Pettit TH, Isenberg SJ, Simons KB. Ligneous conjunctivitis: an autosomal recessive disorder. J Pediatr Ophthalmol Strabismus 1986;23:137-40.

10. Ramsby ML, Donshik PC, Makowski GS. Ligneous con?junctivitis: Biochemical evidence for hypofibrinolysis. Inflammation 2000;24:45-71.

11. Rubin A, Buck D, Macdonald MR. Ligneous conjunctivi?tis involving the cervix. Case report. Br J Obstet Gynaecol 1989;96:1228-30.

12. Heidemann DG, Williams GA, Hartzer M, Ohanian A, Citron ME. Treatment of ligneous conjunctivitis with top?ical plasmin and topical plasminogen. Cornea 2003;22: 760-2.

13. Teresa Sartori M, Saggiorato G, Pellati D, Casonato A, Spiezia L, Pontara E, et al. Contraceptive pills induce an improvement in congenital hypoplasminogenemia in two unrelated patients with ligneous conjunctivitis. Thromb Haemost 2003;90:86-91

Kaynak Göster

1071 386

Arşiv
Sayıdaki Diğer Makaleler

Methylenetetrahydrofolate Reductase Enzyme Mutations and Relationship of Homocysteine Vitamin B12 and Folate Blood Levels

C. Tuba GÜNEBAK ŞAHİN, Berkan SAYAL, Erdal COŞGUN, H. Tanju BESLER, M. Sinan BEKSAÇ

Spontaneous Ovarian Pregnancy and Over Protective Management: A Case Report

Hatice Ender SOYDİNÇ, Mehmet Sıddık EVSEN, Muhammet Erdal SAK, Fatmanur ÇAÇA, Ali ÖZLER

HELLP ve Muhtemel Anti-Fosfolipid Sendromu Olan Bir Hastada Karaciğer Enfarktı

Cihan KAYA, HÜSEYİN CENGİZ, MURAT EKİN, Ammar KANAWATİ, LEVENT YAŞAR

''Near Miss'' Obstetric Cases: 4 Years Experience of a Tertiary Center

HÜSEYİN CENGİZ, Cihan KAYA, Ramazan ATEŞ, Yusuf Ziya YENER, MURAT EKİN, LEVENT YAŞAR

Prenatal Diagnosis of Sirenomelia

M. Aykut ÖZEK, Mert TURĞAL, Özgür ÖZYÜNCÜ, M. Sinan BEKSAÇ

Diagnostic Dilemma in Rudimentary Horn Pregnancies: Report of the Eight Cases and a Literature Review

Mehmet SIDDIK EVSEN, Ali ÖZLER, Hatice Ender SOYDİNÇ, ABDULKADİR TURGUT, Neval Yaman GÖRÜK, Ahmet YALINKAYA, Muhammet Erdal SAK

A Rare Coexistence in an Infertile Woman: Ligneous Disease in Cervix and Conjunctiva

Murat ÖZEKİNCİ, Mehmet SAKINCI, Cem Y. SANHAL, Elif PEŞTERELİ, Münire ERMAN AKAR, İnanç MENDİLCİOĞLU

A Case of Laparoscopic Sacrohysteropexy: A Uterus Preserving Surgical Procedure for the Treatment of Uterine Prolapse

Özge Senem YÜCEL, İlker SELÇUK, Aslıhan YAZICIOĞLU, GÖKHAN BOYRAZ, Gürkan BOZDAĞ, İbrahim ESİNLER

Bacterial Vaginosis Bacterial and Epithelial Cell Adhesion Molecules

Sayeste DEMİREZEN, Aydan MUTLU, M. Sinan BEKSAÇ

The Effects of Preeclampsia Severity and Thrombocytopenia on the Prognosis of Hypertensive Pregnant Women

Emre BEŞE, Fatma DEVRAN BILDIRCIN, Erdal MALATYALIOĞLU