Onur HURŞİTOĞLU, Ergul BELGE KURUTAS, Ömer Faruk UYGUR, Nurinnisa ÖZTÜRK

Bipolar Tanılı Hastalarda Azalmış GPER düzeyleri

Amaç: Literatürde östrojen ve reseptörlerinin, hastalığın seyri, şiddeti ve pik dönemlerindeki cinsiyet farklılıkları nedeniyle bipolar bozukluğun etiyopatogenezinde önemli rol oynadığına dair artan kanıtlar bulunmaktadır. Bu bağlamda üreme sisteminin yanı sıra sinir sistemi, endokrin sistem ve kardiyovasküler sistemde de tanımlanan ve östradiolün nörolojik faydalarına aracılık eden GPER’in bu hastalıktaki rolünü daha iyi anlamak önemlidir. Yöntemler: Bu çalışmada, ötimik dönemdeki bipolar bozukluk hastaları ile yaş, cinsiyet ve vücut kitle indeksi açısından eşleştirilmiş sağlıklı kontrollerde serum GPER düzeylerini karşılaştırmayı amaçladık. Sonuçlar: Bu çalışmada hasta gruplarında kontrol gruplarına göre her iki cinsiyette ayrı ayrı ve toplamda serum GPER düzeylerinin düşük olduğunu saptadık. Tartışma: Sonuçlarımız ön çalışma olarak değerlendirilmeli ve daha büyük örneklemlerle daha homojen gruplarda tekrarlanmalıdır. Ek olarak, G1'in depresif dönemdeki bipolar hastalarda terapötik etkinliği konusunda daha fazla araştırma yapılması gerektiğine inanıyoruz.

Anahtar Kelimeler:

GPER, Östrojen Reseptörleri, Estradiol, Cinsiyet

Decreased Levels of G Protein-Coupled Estrogen Receptor in Bipolar Patients

Objectives: There is increasing evidence in the literature that estrogen and its receptors play an important role in the etiopathogenesis of bipolar disorder due to gender differences in the course, severity and peak periods of the disease. In this context, GPER, which is defined in the reproductive system as well as the nervous system, endocrine system and cardiovascular system, and mediates the neurological benefits of estradiol; It is important to better understand its role in this disease. Method: In this study, we aimed to compare serum GPER levels in euthymic bipolar disorder and healthy controls matched for age, sex and body mass index. Results: In this study, we found decreased serum GPER levels in both genders separately and in total in the patient groups compared to the control groups. Conclusion: Our results should be considered preliminary and should be repeated in more homogeneous groups with larger samples. In addition, we believe that further studies should be conducted on the therapeutic efficacy of G1 in depressive bipolar patients.

Keywords:

GPER, Estrogen Receptors, Estradiol, Gender,

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