Burak TURGUT, Peykan TÜRKÇÜOĞLU, Tamer DEMİR, Emrah KAN, Selahattin KUMRU

Menapoz Sonrası Dönemde Farklı Hormon Replasman Tedavilerinin Göz Yaşı Fonksiyonlarına Etkileri

Amaç: Postmenapozal dönemde kullanılan hormon replasman tedavisinde östrojen, östrojen+progesteron ve östrojen+progesteron+androjen etkili hormon preparatlarının gözyaşı fonksiyonları üzerindeki etkilerini karşılaştırmak. Gereç ve Yöntem: Çalışmaya katılan, 26'si östrojen (Grup 1), 15'i östrojen+ medroksiprogesteron asetat (Grup 2), 19'u Tibolon (Grup 3) kullanan ve 24'ü ise ilaç kullanmayan (Grup 4=kontrol) toplam 84 menapoz hastasının ayrıntılı oftalmolojik muayeneleri yapılarak Schirmer testi ve gözyaşı kırılma zamanı (GKZ) değerleri kaydedildi; sağ ve sol göz ortalama değerleri çalışmada kullanıldı. Tedavi alan gruplar kendi aralarında ve kontrol grubu ile karşılaştırılarak sonuçlar istatistiksel olarak değerlendirildi. Bulgular: Çalışmaya katılan hastaların yaş ortalamaları 51.97±5.70 idi. Schirmer testi, sağ ve sol göz ortalamaları grup 1'de 18.57±3.98 mm, grup 2' de 20.80±2.84 mm, grup 3' de 21.00±5.05 mm, kontrol grubunda (grup 4); 13.75±3.49 mm olarak tespit edildi. Ortalama GKZ, sırasıyla grup 1'de 12.05±3.45 sn, grup 2'de, 12.90±2.13 sn, grup 3' de, 14.00±2.77 sn, kontrol grubunda (grup 4); 8.10±3.21 sn olarak tespit edildi. HRT alan grupların tümünde Schirmer ve GKZ değerleri, kontrol grubuna göre istatistiksel anlamlı yüksekti. Ancak HRT alan gruplar arasında istatistiksel anlamlı fark yoktu. Sonuç: Menapoz sonrası dönemde HRT'si ilaç içeriğinden bağımsız olarak gözyaşı fonksiyonlarının korunmasına etkilidir.©2008, Fırat Üniversitesi, Tıp Fakültesi

Anahtar Kelimeler:

Hormon replasman tedavisi, gözyaşı fonksiyonları, postmenapozal dönem

The Effects of Various Hormone Replacement Treatments on Tear Functions in Postmenopausal Women

Objectives: The effects of various hormonal replacement treatments (HRT) on tear functions in postmenopausal women were evaluated. Material and Methods: The study group consisted of 84 postmenopausal women, 26 patients using conjugated estrogen (Group1), 15 patients using conjugated estrogen + medroxyprogesterone acetate (Group 2), 19 patients using Tibolone (Group 3) and 24 patients as control group (Group 4). Schirmer test was performed and tear break up time (BUT) was measured. The mean of right and left eye measurements were used in the study. Groups that receiving HRT were compared with each other and with control group. Results: Mean age of 84 postmenopausal women was 51.97±5.70 years. Mean value of right and left eye Schirmer test was 18.57±3.98 mm in group 1, 20.80±2.84 mm in group 2, 21.00±5.05 mm in group 3, and 13.75±3.49 mm in group 4. Mean tear BUT was 12.05±3.45 sec. in group 1, 12.90±2.13 sec. in group 2, 14.00±2.77 sec. in Group 3, 8.10±3.21 sec. in Group 4. Schirmer test results and tear break up time of all groups that receive HRT were statistically higher than the control group. There was no statistical significant difference between the HRT receiving groups. Conclusion: HRT, independent from its content, preserves tear functions in postmenopausal women..©2008, Firat University, Medical Faculty.

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Kabul Tarihi:24.09.2007