Discussion and ResultThe results indicate that, although in an appreciable number of cases there are chromosome abnormalities and that the relatively homogenous clinical picture, apart from D-trisomy syndrome cases, chromosome abnormalities are not consistent in the cleft lip and/or palate. It has also been shown that chromosomal abnormalities in the condition are quite heterogenous, a .result supported by different works.It seems clear that more studies are required to establish the chromosomal basis of the cleft lip and/or palate.