Subhas G BABU, Renita Lorina CASTELİNO, Supriya BHAT, Ullal Harshini DEVI, Devika S PILLAI, Sajad Ahmad BUCH

Ferritin Levels in Serum and Saliva of Oral Cancer and Oral Potentially Malignant Disorders

Objective: Oral cancer remains a substantial health burden worldwide despite creditable developments in its prevention, detection, and treatment. The early detection of oral cancer offers high chances of survival and improves response to therapy making overall healthcare affordable. The aim and objective of this study were to compare and correlate serum and saliva ferritin levels in healthy subjects, oral potentially malignant disorders, and subjects with oral cancer and to assess the role of saliva as a valuable diagnostic tool. Methods: Totally 30 participants each in 3 groups comprising healthy subjects, oral potentially malignant disorders, and oral cancer constituted the sample size. Enzyme-linked immunosorbent assay method was employed for serum and saliva ferritin levels. Results: The respective mean serum ferritin and saliva ferritin levels were increased significantly in subjects with oral cancer (296.62 ± 82.54 ng/mL and 80.44 ± 12.94 ng/mL, respectively) and decreased significantly in oral potentially malignant disorders (69.83 ± 17.39 ng/mL and 17.49 ± 5.40 ng/mL, respectively) with a highly significant P

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1. Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol. 2009;45:309-316.
2. Montero PH, Patel SG. Cancer of the Oral Cavity. Surg. Oncol. Clin. N. Am. 2015;24:491-508.
3. Silverman S, Kerr AR, Epstein JB. Oral and Pharyngeal Cancer Control and Early Detection. J. Cancer Educ. 2010;25:279-281.
4. McCullough M, Prasad G, Farah C. Oral mucosal malignancy and potentially malignant lesions: An update on the epidemiology, risk factors, diagnosis and management. Aust. Dent. J. 2010;55: 61-65.
5. Sarode SC, Sarode GS, Tupkari JV. Oral potentially malignant disorders: a proposal for terminology and definition with review of literature. J Oral Maxillofac Pathol. 2014;18(Suppl 1):S77-S80. [CrossRef]
6. Sarode SC, Sarode GS, Karmarkar S. Early detection of oral cancer: detector lies within. Oral Oncol. 2012;48(3):193-194. [CrossRef]
7. Min Pang BS, Connor JR. Role of ferritin in cancer biology. J Cancer Sci Ther Ther. 2015;7:155-160.
8. Baharvand M, Manifar S, Akkafan R, Mortazavi H, Sabour S. Serum levels of ferritin, copper, and zinc in patients with oral cancer. Biomed J. 2014;37(5):331-336. [CrossRef]
9. Toyokuni S. Role of iron in carcinogenesis: cancer as a ferrotoxic disease. Cancer Sci. 2009;100(1):9-16. [CrossRef]
10. Chen P, De Meulenaere E, Deheyn DD, Bandaru PR. Iron redox pathway revealed in ferritin via electron transfer analysis. Sci Rep. 2020;10(1):4033. [CrossRef]
11. Khanna V, Karjodkar F, Robbins S, Behl M, Arya S, Tripathi A. Estimation of serum ferritin level in potentially malignant disorders, oral squamous cell carcinoma, and treated cases of oral squamous cell carcinoma. J Cancer Res Ther. 2017;13(3):550-555. [CrossRef]
12. Maxim PE, Veltri RW. Serum ferritin as a tumor marker in patients with squamous cell carcinoma of the head and neck. Cancer. 1986;57(2):305-311. [CrossRef]
13. Inal E, Laçin M, Asal K, et al. The significance of ferritin, lipid-associated sialic acid, CEA, squamous cell carcinoma (SCC) antigen, and CYFRA 21-1 levels in SCC of the head and neck. Kulak Burun Bogaz Ihtis Derg. 2004;12(1-2):23-30.
14. Richie JP, Kleinman W, Marina P, Abraham P, Wynder EL, Muscat JE. Blood Iron, glutathione and Micronutrient levels and the risk of oral cancer. Nutr Cancer. 2008;60(4):474-482. [CrossRef]
15. Bhatavdekar JM, Vora HH, Goyal A, Shah NG, Karelia NH, Trivedi SN. Significance of ferritin as a marker in head and neck malignancies. Tumori. 1987;73(1):59-63. [CrossRef]
16. Yuan C, Yang K, Tang H, Chen D. Diagnostic values of serum tumor markers Cyfra21-1, SCCAg, ferritin, CEA, CA19-9, and AFP in oral/ oropharyngeal squamous cell carcinoma. Onco Targets Ther. 2016;9:3381-3386. [CrossRef]
17. Vinzenz K, Schönthal E, Zekert F, Wunderer S. Diagnosis of head and neck carcinomas by means of immunological tumor markers. J Craniomaxillofac Surg. 1987;15(5):270-277. [CrossRef]
18. Thakur M, Guttikonda VR. Estimation of haemoglobin, serum iron, total iron-binding capacity and serum ferritin levels in oral submucous fibrosis. A clinic pathological study. J Oral Maxillofac Pathol. 2017;21:31-35.