Bükay YENİCE GÜRSU, Elif AKSÖZ, Büşra ASLAN, Betül YILMAZ ÖZTÜRK, İlknur DAĞ

Yaşlı sıçanlarda skopolamin kullanımının karaciğer dokuları üzerine morfolojik ve ultrayapısal etkilerinin değerlendirilmesi

Özet: Skopolamin güçlü antikolinerjik etkileri olan doğal bir bitki alkaloididir. Muskarinik reseptörleri rekabetçi bir şekilde inhibe eder ve hem periferik antimuskarinik etkiler, hem de merkezi sedatif, antiemetik ve amnezik etkiler üretir. Uzun yıllardır bulantı, hareket hastalığı, alerjik rinit, duodenal ülser hastalığı, gastrointestinal rahatsızlık ve spazm, fonksiyonel bağırsak sendromu ve hiperaktif mesane tedavisinde antiemetik, antisekretuar ve antispazmotik ajan olarak kullanılmaktadır. Skopolamin, karaciğer tarafından metabolize edilir, ancak genellikle sadece kısa süreler için düşük dozlarda (

Anahtar Kelimeler:

Karaciğer, Skopolamin

Evaluation of the morphological and ultrastructural effects of on liver tissues of scopolamine use in old rats

Evaluation of the morphological and ultrastructural effects of on liver tissues of scopolamine use in old rats Abstract: Scopolamine is a natural plant alkaloid with strong anticholinergic effects. It competitively inhibits muscarinic receptors and produces both peripheral antimuscarinic effects and central sedative, antiemetic and amnesic effects. It has been used as an antiemetic, antisecretory and antispasmodic agent in the treatment of nausea, motion sickness, allergic rhinitis, duodenal ulcer disease, gastrointestinal discomfort and spasm, functional bowel syndrome and hyperactive bladder for many years. Scopolamine is metabolized by the liver, but is usually given in low doses (

Keywords:

Liver, Scopolamine,

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