Monoklonal Antikorlar (MKA) ve Bunların Hastalıklarda Kullanılması

İnsan ve hayvanların vücudu, dışarıdan giren ve özellikle patojenik karakterde olan (bakteri, virus, parazit vs) etkenlere karşı immunolojik bir yanıt verecek tarzda teçhiz edilmiştir. Partiküler nitelikte olanların yanısıra, eriyebilir özellikteki (protein , polisakkarit ve/veya bunların kompleksleri) substanslara da benzer tarzda bir reaksiyon gösterir. Oluşan bu bağışıksal yanıt başlıca iki tarzda kendini belli etmektedir. Bunlarda, humoral (sıvısal) yanıt ve Sellüler (hücresel) yanıt. Uyarımın şiddetine, konakcının bağışıklık durumuna ve immunojenin bazı özelliklerine ( yapısı, miktarı, veriliş yolu vs. ) göre, bu yanıtlardan biri daha etkin olmakta diğeri ise ikinci planda kalmaktadır. Bazen de her ikisinin de aynı derecede etkin olabildiği veya hiç olamadığı durumlar da (immunolojik yanıtsızlık, immunolojik paraliz)ortaya çıkabilmektedir. Bu son durum , özellikle, immunojenin çok az veya cok fazla verildiği hallerde görülmektedir.

Anahtar Kelimeler:

MKA, Monoklonal Antikorlar, Monoklonal Antikorların Hastalıklarda Kullanılması, MKA Hastalıklarda Kullanılması, Mustafa ARDA, 1989, Etlik Veteriner Mikrobiyoloji Dergisi

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