Poliprol-Karbon Nanotüp Modifiye Elektrotta Farmasötik Tabletlerde Metamizol Sodyumun Voltammetrik Tayini

Polipirol-karbon nanotüp (PPy-CNT) kompozit elektrot, ultrasonikasyon ile eşleştirilmiş pulslu polimerizasyon tekniği ile hazırlanmıştır. Bu teknik, hem ultrasonikasyon hem de elektrokimyasal polimerizasyonun avantajlarına sahiptir. PPy-CNT kompoziti pulslu depolama tekniği ile camımsı karbon elektrot (GCE) yüzeyine kolayca modifiye edilmiş, ve metamizol yükseltgenmesine karşı camımsı karbon elektroda göre katalitik aktivitesi yüksek bir yüzey elde edilmiştir. Hazırlanan elektrot taramalı electron mikroskopu ile karakterize edilmiş ve pH:2 Britton-Robinson tamponunda metamizol davranışı incelenmiştir. Diferansiyel pulse voltammetrisi ile lineer aralık 5-500 mg L-1 olarak saptanmış ve belirtme alt sınırı1.6 mg L-1 olarak hesaplanmıştır. Yapılan tüm çalışmalar göstermiştir ki, PPY-CNT/GCE, metamizol tayini için yüksek duyarlılık, seçimlilik ve kararlılığa sahiptir. PPy-CNT/GCE sensörü novalgine tablet örneğine uygulanarak gerçek örnek analizi başarı ile gerçekleştirilmiştir.

Anahtar Kelimeler:

PPy-CNT, Metamizol Sodyum, voltammetry

Voltammetric Determination of Metamizol Sodium in Pharmaceutical Tablets at Polypyrrole-Carbon Nanotube Modified Electrodes

Poly pyrrole-carbon nanotube (PPy-CNT) composite electrodes were prepared with ultrasonication assisted pulsed polymerization technique. This technique possesses both advantages of ultrasonication and electrochemical polymerization. PPy-CNT composite was modified on the bare glassy carbon electrode (GCE) surface easily with pulsed deposition technique that provide more catalytically active surface compared to the bare GCE towards metamizol oxidation. Resulted electrode was characterized by scanning electron microscopy and used for investigation of metamizaol in pH:2 Britton-Robinson buffer solution. In the differential pulse voltammetric determination, the linear range was found as 5-500 mg L-1 with a detection limit of 1.6 mg L-1 . The overall results showed that PPy-CNT electrode has an excellent sensitivity, selectivity and anti-fouling properties for the voltammetric determination of metamizol. PPy-CNT/GCE sensor was applied succesfully to the determination of metamizol in novalgine sample.

Keywords:

PPy-CNT Metamizol Sodium, Voltammetry, Pulsed Amperometric Deposition,

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