Naftalenilmetilen Hidrazin Türevlerinin Antimikrobiyal Aktiviteleri

Klinik mikrobiyoloji ve antibakteriyal araştırmalarda, ilaca dirençli patojenlerin önemi artmaktadır. Hidrazin tipi bileşikler, mikrobiyal enfeksiyonlarda çoklu ilaca dirençli ajanların araştırılması için önemli bir kimyasal sınıf olarak bilinmektedir. Bu çalışmada, belirli Naftalenilmetilen Hidrazin türevlerinin antimikrobiyal aktiviteleri incelenerek bu bileşiklerin etkinlikleri değerlendirilmiştir. Test edilen bileşiklerin antimikrobiyal etkinlikleri, 2-kat seri dilüsyon yöntemi kullanılarak, Staphylococcus aureus, Methicillin-Resistant-Staphylococcus aureus (MRSA), Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli ve Candida albicans’a karşı araştırılarak değerlendirilmiştir. Test edilen bileşiklerin Minimum İnhibisyon Konsantrasyonu (MİK), siprofloksasin, ampisilin ve mikonazol gibi standart referans bileşiklere karşı belirlenmiştir. Aktivite sonuçlarına göre, bileşikler genel olarak zayıf antibakteriyal etki göstermelerine rağmen, 1e ve 1h bileşikleri özellikle MRSA suşlarına karşı önemli antibakteriyal etki göstermişlerdir.

Anahtar Kelimeler:

antimikrobiyal, hidrazin, indol, MRSA, Naftalen

Antimicrobial Activities of Naphthalenylmethylen Hydrazine Derivatives

In clinical microbiology and antibacterial research, the significance of drug-resistant pathogens is growing up. Hydrazine-type compounds constitute the main classes of chemicals for the investigation of multidrug resistant agents which causes microbial infections. In the current study antimicrobial activities of certain Naphthalenylmethylen Hydrazine derivatives were examined to appraise their efficacy. The effectiveness of new compounds were evaluated using 2-fold serial dilutions against Staphylococcus aureus, Methicillin-Resistant-Staphylococcus aureus (MRSA), Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, and Candida albicans. Minimum inhibitory concentration (MIC) was determined for test compounds and for the reference standards Ciprofloxacin, ampicillin, and miconazole. According to the results, although the new compounds demonstrated poor antibacterial effects in general, the 1e and 1h compounds showed off significant antibacterial effects, especially against MRSA strains.

Keywords:

Antimicrobial, Hydrazine, Indole, MRSA, Naphthalene,

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