Sex Cord-Stromal Tumor with Annular Tubules of the Ovary

Sex cord-stromal tumors with annular tubules (SCTAT) of the ovary are rare. They have two clinical presentation forms: the syndromic form, which is associated with Peutz-Jeghers syndrome, and the non-syndromic form, which is frequently seen in the second or third decades. We describe a 13-year-old patient who underwent left oophorectomy. Macroscopically, the mass was 16×13×8 cm in diameter, encapsulated, and lobulated. It showed a yellow-to-orange solid cut surface with small cystic areas and hemorrhagic cleft-like spaces. Microscopically, the tumor had nodular areas that were separated with fibrous stroma. They were composed of tubules, which were lined by columnar shaped cells with eosinophilic cytoplasm, nuclear palisading, and central Periodic Acid Schiff (PAS)-positive eosinophilic hyaline bodies. Immunohistochemically, the tumor cells were strongly positive for inhibin. Finally, the tumor was diagnosed as non-syndromic ovarian SCTAT.

Kaynakça

Roth LM. Sex-cord stromal tumors of the ovary. In Fox H, Wells M, Editors. Obstetrical and Gynaecological Pathology. 5th ed. Churchill Livigstone; 2003. p.745-70.

Russel P, Robboy SJ, Prat J. Sex-cord stromal and steroid cell tumors of the ovaries. In Robboy SJ, Mutter GL, Prat J, Bentley RC, Russel P, Anderson MC, Editors. Pathology of the Female Reproductive Tract. 2. ed. Churchill Livigstone; 2009. p. 693-727. [CrossRef]

Srivatsa PJ, Keeney GL, Podratz KC. Disseminated cervical adenoma malignum and bilateral ovarian sex-cord tumors with annuler tubules with Peutz Jeghers syndrome. Gynecol Oncol 1994; 53(2): 256-64. [CrossRef]

Ayadi-Kaddour A, Bouraoui S, Bellil K, Bellil S, Kchir N, Zitouna MM, et al. Colonic adenocarcinoma and bilateral malignant ovarian sex cord tumor with annular tubules in Peutz-Jeghers syndrome. Patho- logica 2004; 96(3): 117-20.

Mangili G, Taccagni G, Garavaglia E, Carnelli M, Montoli S. An un- usual admixture of neoplastic and metaplastic lesions of the female genital tract in the Peutz Jeghers syndrome. Gynecol Oncol 2004; 92(1): 337-42. [CrossRef]

Shen K, Wu PC, Lang JH, Huang RL, Tang MT, Lian LJ. Ovarian sex-cord tumor with annular tubules. A report of six cases. Gynecol Oncol 1993; 48(2): 180-4. [CrossRef]

Moon WS, Lee DG. Ovarian sex-cord tumor with annuler tubules in a patient with Turner syndrome. J Korean Med Sci 1998; 13(1): 89-94. [CrossRef]

Galiana SG, Monteagudo C, Tortajada M, Llombart A, Cano A. Ovar- ian sex cord tumor with annular tubules in a woman with premature ovarian failure. Fertil and Steril 2001; 76(6): 1264-6. [CrossRef]

Hirschman SA, Dottino P, Deligdisch L, Szporn A. Cytology of Sex- cord tumor with annuler tubules: a cese report. Diagn Cytopathol 1998; 81: 362-4. [CrossRef]

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