Langerhans cell histiocytosis (LCH) is a rare group of idiopathic diseases characterized by abnormal proliferation of bone marrow-derived dendritic cells called histiocytes. It is more common in childhood, but in the literature, some adult cases have been reported. For several reasons, the disease is more familiar to pediatricians than it is to physicians handling adult cases; therefore, the diagnosis of adult cases is often delayed or missed. The clinical course of LCH is variable, ranging from a self-healing solitary bone lesion to a widely disseminated life-threatening disease. The diagnosis of LCH should be based on histologic and immunophenotypic examination of perilesional skin. In this report, we present a case of LCH in a 66-yearold woman with bone, skin, and pituitary gland involvement; this case emphasizes that a patient with LCH should undergo careful multidisciplinary evaluation.
Aricò M, Girschikofsky M, Généreau T, Klersy C, McClain K, Grois N, et al. Langerhans cell histiocytosis in adults. Report from the Interna- tional Registry of the Histiocyte Society. Eur J Cancer 2003; 39(16): 2341-8. [CrossRef]
Ma J, Jiang Y, Chen X, Gong G. Langerhans cell histiocytosis misdi- agnosed as liver cancer and pituitary tumor in an adult: A case report and brief review of the literature. OncolLett 2014; 7(5): 1602-1604. [CrossRef]
Aricò M, Danesino C. Langerhans cell histiocytosis: is there a role for genetics? Haematologica. 2001; 86(10): 1009-14.
Abla O, Egeler RM, Weitzman S. Langerhans cell histiocytosis: Cur- rent concepts and treatments. Cancer Treat Rev 2010; 36(4): 354-9. [CrossRef]
Berhens RJ, Levi AW, Westra WH, Dutta D, Cooper DS. Langerhans cell histiocytosis of the thyroid: a report of two cases and review of the literature. Thyroid2001; 11(7): 697-05. [CrossRef]
Satter EK, High WA. Langerhans cell histiocytosis: a review of the current recommendations of the Histiocyte Society. Pediatr Dermatol 2008; 25(3): 291-5. [CrossRef]
Girschikofsky M, Arico M, Castillo D, Chu A, Doberauer C, Fichter J, et al. Management of adult patients with Langerhans cell histiocytosis: recommendations from an expert panel on behalf of Euro-Histio-Net. Orphanet J RareDis. 2013; 8(5): 72. [CrossRef]
García Gallo MS, Martínez MP, Abalovich MS, Gutiérrez S, Guitel- man MA. Endocrine manifestations of Langerhans cell histiocytosis diagnosed in adults. Pituitary 2010; 13(4): 298-303. [CrossRef]
Kwon OS, Cho KH, Song KY. Primary cutaneous Langerhanscell his- tiocytosis Treated with photochemotherapy. J Dermatol 1997; 24(1): 54-6. [CrossRef]
Hoeger PH, Nanduri VR, Harper JI, Atherton DA, Pritchard J. Long- term follow up of topical mustine treatment for cutaneous langerhans cell histiocytosis. Arch Dis Child 2000; 82(6): 483-7. [CrossRef]
Lau L, Krafchik B, Trebo MM, Weitzman S. Cutaneous Langerhans cell histiocytosis in children under one year. Pediatr Blood Cancer 2006; 46(1): 66-71. [CrossRef]
Helmbold P, Hegemann B, Holzhausen HJ, Klapperstück T, Marsch WC. Low-dose oral etoposide monotherapy in adult Langerhans cell histiocytosis. Arch Dermatol 1998; 134(10): 1275-8. [CrossRef]