Ali Bestemi KEPEKÇİ, Mustafa Yavuz KÖKER, Ahmet Hamdi KEPEKÇİ

Allerjik rinitli çocuklarda indoor ve outdoor inhalen alerjen prevalans›n›n araﬂt›r›lmas›

Amaç: Bu çal›ﬂman›n amac›, ‹stanbul’da allerjik rinitli (AR) çocuklarda deri prick testi (DPT) reaktivitesine dayanan aeroallerjen duyarl›l›¤›n›n prevalans›n›n belirlenmesidir. Yöntem: Pozitif DPT olan 729 AR’li hastan›n dahil edildi¤i bu çal›ﬂma, üç yaﬂ grubu halinde incelendi. Bu hastalar üzerinde polen, ev tozu akarlar›, hayvan epiteli ve mantarlar içeren ekstraktlarla birlikte DPT yap›ld›. Araﬂt›rmaya dahil olan hastalar DPT’de en az bir alerjene karﬂ› pozitif olan bir tepkiye sahiptir. Bulgular: Pozitif DPT sonuçlar› olan 729 hastan›n alerjen prevelans›, ev tozu akarlar› için %33, polen için %31, mantarlar için %19 ve hayvan epiteli için %17 idi. Aeroalerjenlere karﬂ› duyarl›l›k, yaﬂ artt›kça belirgin olarak azald› (p

An investigation of the prevalence of indoor and outdoor inhalant allergens in children with allergic rhinitis

Objective: The aim of the present study was to determine the prevalence of the aeroallergens sensitivity among children with allergic rhinitis in the province of Istanbul in Turkey, based on skin prick test (SPT) reactivity. Methods:This study, including 729 AR patients with positive SPT, was conducted in three age groups. SPT with extracts including pollens, house dust mites (HDMs), animal dander’s (ADs) and molds was performed on these patients. All these patients have a positive reaction to at least one allergen with SPT. Results: The allergen prevalence of 729 patients with positive SPT results was 33% for HDMs, 31% for pollen, 19% for molds and 17% for ADs. The sensitivity to aeroallergens significantly decreased as the age increased (p

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Assarehzadegan MA, Shakurnia A, Amini A. The most common aeroallergens in a tropical region in Southwestern Iran. World Allergy Organ J 2013;6:7.
Kay AB. Overview of ‘allergy and allergic diseases: with a view to the future’. Br Med Bull 2000;56:843–64.
Harrison P. Creature comforts – living with mites and moulds. Clin Exp Allergy 1999;29:148–9.
Hirsch T, Hering M, Bürkner K, et al. House-dust-mite allergen concentrations (Der f 1) and mold spores in apartment bedrooms before and after installation of insulated windows and central heating systems. Allergy 2000;55:79–83.
Sporik R, Ingram JM, Price W, Sussman JH, Honsinger RW, Platts-Mills T. Association of asthma with serum IgE and skin test reactivity to allergens among children living at high altitude. Tickling the dragon’s breath. Am J Respir Crit Care Med 1995; 151:1388–92.
Platts-Mills TA, Vervloet D, Thomas WR, Aalberse RC, Chapman MD. Indoor allergens and asthma: report of the Third International Workshop. J Allergy Clin Immunol 1997;100:S2– S24.
Platts-Mills TA, Thomas WR, Aalberse RC, Vervloet D, Champman MD. Dust mite allergens and asthma: report of a second international workshop. J Allergy Clin Immunol 1992;89: 1046–60.
Davies JM, Li H, Green M, Towers M, Upham JW. Subtropical grass pollen allergens are important for allergic respiratory diseases in subtropical regions. Clin Transl Allergy 2012;2:4.
Medek DE, Kljakovic M, Fox I, Pretty DG, Prebble M. Hay fever in a changing climate: linking an internet-based diary with environmental data. Ecohealth 2012;9:440–7.
Maunsell K. The impact of aerobiology on allergy. Acta Allergol 1971;26:329.
Singh AB, Kumar P. Aeroallergens in clinical practice of allergy in India. An overview. Ann Agric Environ Med 2003;10:131– 6.
Fereidouni M, Hossini RF, Azad FJ, Assarezadegan MA, Varasteh A. Skin prick test reactivity to common aeroallergens among allergic rhinitis patients in Iran. Allergol Immunopathol (Madr) 2009; 37:73–9.
Bousquet J, Khaltaev N, Cruz A, et al.; World Health Organization; GA(2)LEN; AllerGen. Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 2008;63 Suppl 86:8–160.
Incorvaia C, Cavaliere C, Frati F, Masieri S. Allergic rhinitis. J Biol Regul Homeost Agents 2018;32Suppl1:61–6.
Tran NP, Vickery J, Blaiss MS. Management of rhinitis: allergic and non-allergic. Allergy Asthma Immunol Res 2011;3:148– 56.
Watanabe M, Yamasaki A, Burioka N, et al. Correlation between Asian dust storms worsening asthma in Western Japan. Allergol Int 2011;60:267–75.
Chew F, Lim S, Goh D, Lee B. Sensitization to local dust-mite fauna in Singapore. Allergy 1999;54:1150–9.
Farhoudi A, Razavi A, Chavoshzadeh Z, Heidarzadeh M, Bemanian MH, Nabavi M. Descriptive study of 226 patients with allergic rhinitis and asthma in Karaj city. Iran J Allergy Asthma Immunol 2005;4:99–101.
Kashef S, Kashef MA, Eghtedari F. Prevalence of aeroallergens in allergic rhinitis in Shiraz. Iran J Allergy Asthma Immunol 2003;2: 185–8.
Akcakaya N, Cokugras H, Camcioglu Y, Ozdemir M. Skin test hypersensitivity for childhood asthma in Istanbul during a period of 16 years. Allergol Immunopathol (Madr) 2005;33:15–9.
Harmanc› K, Bak›rtaﬂ A, Türktaﬂ ‹. Sensitization to aeroallergens in preschool children with respiratory problems in Ankara, Turkey. Turkish Respiratory Journal 2006;7:10–4.
Keil T, Bockelbrink A, Reich A, et al. The natural history of allergic rhinitis in childhood. Pediatr Allergy Immunol 2010;21:962–9.