Meltem ERGÜN(), Nesrin TURHAN(), Nurgül ŞAŞMAZ()

Kalp transplantasyonu geçirmiş bir olguda gelişen MALT (mukoza ilişkili lenfoid doku) lenfoma: Olgu sunumu

Transplantasyon yapılmış hastalarda immunsupresif tedavinin sonucu olarak nonHodgkin lenfoma görülme sıklı¤ı artmıştır. MALT lenfoma, nakil sonrası gelişen di¤er lenfoproliferatif hastalıklardan daha az agresiftir ve ayrı bir grup olarak de¤erlendirilmektedir. MALT lenfoma, iyi bilinen bir Helicobacter pylori ilişkili B hücre orijinli tümördür ve solit organ alıcılarında nadir olgu serileri şeklinde bildirilmiştir. Biz 67 yaşında bir erkek hastada kalp nakli yapıldıktan 12 yıl sonra gelişen düşük dereceli B hücreli gastric MALT lenfomayı bildiriyoruz

Anahtar Kelimeler:

MALToma, kalp nakli, immunsupresyon

Gastric lymphoma of mucosa-associated lymphoid tissue (MALT) following cardiac transplantation: A case report

An increased incidence of non-Hodgkin's lymphoma is seen in post-trans-plantation patients, as a consequence of immunosuppression. Mucosa-asso-ciated lymphoid tissue lymphoma ( is usually less aggressive than other post-transplant lymphoproliferative disorders and considered a different form. Mucosa-associated lymphoid tissue lymphoma is a well-known Helicobacter pylori-related tumor of B-cell origin and has been documented in rare case series in solid organ recipients. We describe the case of a 67-year-old man who developed low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue MALT, 12 years after receiving cardiac transplantation.

Keywords:

Malt lymphoma, cardiac transplantation, immunosuppression,

PDF

___

Cockfield SM, Preiksaitis JK, Jewell LD, Parfrey NA. Posttransplant lymphoproliferative disorder in renal allograft recipients. Clinical expe- rience and risk factor analysis in a single center.Transplantation 1993;56:88-96.
Gibson SE, Swerdlow SH, Craig FE, et al. EBV-positive extra-nodal mar- ginal zone lymphoma of mucosa-associated lymphoid tissue in the post- transplant setting: a distinct type of posttransplant lymphoproliferative disorder? Am J Surg Pathol 2011;35:807-15.
Hsi ED, Singleton TP, Swinnen L, et al. Mucosa-associated lymphoid tis- sue-type lymphomas occurring in post-transplantation patients. Am J Surg Pathol 2000;24:100-6.
Aull MJ, Buell JF, Peddi VR, et al. MALToma: a Helicobacter pylori-asso- ciated malignancy in transplant patients: a report from the Israel Penn International Transplant Tumor Registry with a review of published lite- rature. Transplantation 2003;75:225-8.
Wotherspoon AC, Doglioni C, Diss TC, et al. Regression of primary low- grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet 1993;342:575-7.
Shehab TM, Hsi ED, Poterucha JJ, et al. Helicobacter pylori-associated gastric MALT lymphoma in liver transplant recipients. Transplantation 2001;71:1172-5.