Aromatik Schiff Bazları ve Co(II), Ni(II) ve Cu(II) Komplekslerinin Sentezi: Antimikrobiyal Aktivitelerinin İncelenmesi

N,N-dietil-p-fenilendiamin ile salisilaldehit ve 2,4-dihidroksibenzaldehit ayrı ayrı reaksiyona sokulup, iki farklı türde Schiff bazı ligantları sentezlenmiştir. Elde edilen ligandların, Co(II), Cu(II) ve Ni(II) kompleksleri sentezlenmiş ve sentezlenen ligand ve metal komplekslerinin yapıları, FT-IR, UV.-Vis., ICP-OES, TG/DTA/DTG, 1H ve 13C NMR ve elemental analiz (C, H, N ve metal içeriği) teknikleri kullanılarak karakterize edilmiştir. Çalışmada elde edilen ligandların ve metal komplekslerin gram pozitif; Staphylococcus aureus Rosenbach ATCC-6538, Bacillus cereus ATCC 7064, gram negatif; Escherichia coli ATCC-8739, Salmonella typhimurium ve Candida albicans ATCC-90028 maya suşuna karşı biyolojik aktiviteleri incelenmiştir. L1 ligand ve komplekslerinin mikroorganizmalara karşı 8,15-12,99 mm, L2 ve komplekslerinin mikroorganizmalara karşı 7,66-13,88 mm çapında inhibisyon zonları gösterdiği belirlenmiştir. Elde edilen bu kompleks yapıların gram negatif ve gram pozitif suşlara karşı olumlu etkisi bulunduğundan hayatımızda yoğun olarak kullanılan antibiyotiklere alternatif olması mümkündür.

Anahtar Kelimeler:

Metal kompleksi, Antimikrobiyal Aktivite, Schiff Bazı

Synthesis of Aromatic Schiff Bases and Co(II), Ni(II) and Cu(II) Complexes: Investigation of Antımicrobial Activities

Two types of Schiff base ligands were synthesized with the reaction of N,N-diethyl-p-phenylenediamine and salicylaldehyde , 2,4-dihydroxybenzaldehyde separately. Co(II), Cu(II), Ni(II) complexes of the obtained ligants were synthesized and characterized using FT-IR, UV.-Vis., ICP-OES, TG/DTA/DTG, 1H and 13C NMR) and elemental analyses (C, H, N and metal contents analyses). The ligands and metal complexes obtained in the study were gram positive; Staphylococcus aureus Rosenbach ATCC-6538, Bacillus cereus ATCC 7064, gram negative; Escherichia coli ATCC-8739, Salmonella typhimurium and Candida albicans ATCC-90028 yeast strain biological activities against were investigated. It was determined that the L1 ligand and its complexes showed 8.15-12.99 mm diameter inhibition zones against microorganisms, and the L2 and complexes showed 7.66-13.88 mm diameter inhibition zones against microorganisms. Since these complex structures have positive effects against gram-negative and gram-positive strains, it is possible to be an alternative to antibiotics that are used extensively in our lives.

Keywords:

Schiff Base, Metal Complex, Antimicrobial,

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