Hatice ÖZIŞIK, Şevki ÇETİNKALP, Aslı SUNER, Gökhan ÖZGEN, Füsun SAYGILI, Mehmet ERDOĞAN

Tip 2 diabetes mellituslu hastalarda nötrofil lenfosit oranı ile diyabet kontrolü arasındaki ilişki

Amaç: Diyabetik hastalarda Nötrofil lenfosit oranı (NLR) ve glukoz kontrolü arasındaki ilişkiyi araştırmayı amaçladık. Ayrıca Ortalama Trombosit Hacmi (MPV), Kırmızı kan hücre dağılımı (RDW), mikroalbüminüri ve glikozile hemoglobin (HbA1c) arasındaki ilişkiyi saptamaya çalıştık. Gereç ve Yöntem: Bu çalışma Ege Üniversitesi Tıp Fakültesi Endokrinoloji Bilim Dalı'nda gerçekleştirilen retrospektif bir çalışmadır. Tip 2 diabetes mellitus (T2DM) olan 198 hastanın tıbbi kayıtlarını aldık ve bu hastalar kontrollü T2DM li hastalar (Hba1c≤%7) (n=82) ve kontrolsüz T2DM li hastalar (Hba1c>%7) (n=116) olarak iki gruba ayrıldı. Bulgular: NLR, RDW ve MPV'de iki grupta istatistiksel olarak fark yoktu (p=0,123, p=0,298, p=0,595). İki grup arasında 5 yıl ve altı ve 5 yıl üstü T2DM süresi istatistiksel olarak anlamlıydı (p=0,002). NLR, kontrolsüz T2DM'de kontrollü T2DM'den daha yüksek bulunsa da, istatistiksel olarak anlamlı fark yoktu. NLR, RDW, MPV ve WBC'nin ROC eğrisi analizi anlamlı değildi (p>0.05). Sonuç: Çalışmamız T2DM süresinin mikroalbüminüriyi öngörebileceğini ortaya çıkarmıştır ve T2DM'li hastalarda RDW, MPV, NLR ve Hba1c, mikroalbüminüri düzeyleri arasındaki ilişki de değerlendirilmiştir. NLR, RDW ve MPV düzeylerine göre kontrolsüz T2DM ile kontrollü T2DM arasında istatistiksel olarak herhangi bir farklılık tespit etmedik.

The relationship between neutrophil lymphocyte ratio and diabetes control in patients with type 2 diabetes mellitus

Aim: The current study was purposed to examine the association between NLR and the control of glucose in patients with T2DM. We also aimed to reveal correlations between microalbuminuria, Mean Platelet Volume (MPV), Red Blood Cell Distribution (RDW), and glycosylated hemoglobin (HbA1c). Materials and Methods: It was a retrospective study arranged in Ege University, in Endocrinology Department. We collected the fields of 198 patients having type 2 diabetes mellitus (T2DM), and they were categorized into two groups, patients with controlled T2DM (Hba1c≤7%) (n=82) and uncontrolled T2DM (Hba1c>7%) (n=116). Results: There were no statistically significant differences between NLR, RDW and MPV in two groups (p=0.123, p=0.298, p=0.595 respectively). Duration of T2DM 5 years and below and after 5 years between two groups was statistically important (p=0.002). NLR was found higher in uncontrolled T2DM than controlled T2DM, but not statistically significant. Receiver operating characteristic curve of NLR, RDW, MPV, WBC were not found significant (p>0.05). Conclusion: Our study revealed that duration of T2DM may predict microalbuminuria, and evaluated the relationship between RDW, MPV, NLR and Hba1c, microalbuminuria levels together in the patients with T2DM. According to NLR, RDW and MPV levels, we did not detect any statistically differences between uncontrolled T2DM than controlled T2DM.

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